The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia

Panidis, Dimitrios; Georgopoulos, Neoklis A.; Piouka, Athanasia; Katsikis, Ilias; Saltamavros, A.; Decavalas, George; Diamanti-Kandarakis, Evanthia

doi:10.3109/09513590.2010.507283

Cited by 57 publications

(51 citation statements)

References 24 publications

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“…These associations were not seen among users of hormonal contraceptives. Controversies still exist regarding the effect of hormonal contraceptives on circulating levels of AMH (15)(16)(17)(18)(22)(23)(24). In our study on a large cohort of young women from the general population, we observed a small albeit statistically significant difference in median serum AMH of 0.4 ng/mL when comparing users and nonusers of hormonal contraceptives.…”

Section: Discussionmentioning

confidence: 52%

The association between circulating levels of antimüllerian hormone and follicle number, androgens, and menstrual cycle characteristics in young women

Kristensen

Ramlau‐Hansen

Andersen

et al. 2012

Fertility and Sterility

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Section: Discussionmentioning

confidence: 52%

The association between circulating levels of antimüllerian hormone and follicle number, androgens, and menstrual cycle characteristics in young women

Kristensen

Ramlau‐Hansen

Andersen

et al. 2012

Fertility and Sterility

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“…In this respect, various results have been reported regarding the impact of steroid suppression on serum AMH levels. Some studies reported null effect of OCP treatment on serum AMH levels [18,21,22], whereas others revealed suppressed AMH levels in normal cycling women pretreated with OCP [1,15]. In a recent case report it was demonstrated that during 16 week course of menotropin treatment both serum AMH and AFC increased in an IHH patient.…”

Section: Discussionmentioning

confidence: 99%

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

Sönmezer

Özmen

Atabekoglu

et al. 2012

J Assist Reprod Genet

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Purpose The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. Material method(s) Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated. Results Mean serum AMH levels was 3.47±2.15 ng/mL and mean serum peak estradiol was 2196±1705 pg/mL. Mean number of follicles >14 mm, >17 mm on hCG day and MII oocytes were 4.14±3.2, 4±2.5 and 7.28±3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 ± 2.4 and 2.5 ± 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r00.84), grade A embryos (r00.85), serum peak estradiol levels (r00.87), and number of follicles >14 mm (r00.83) and >17 mm (r00.81) on hCG day, respectively. Conclusion AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.

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“…It has been suggested that AMH concentrations are not influenced by oral contraception, 8 but this finding has not been confirmed. 9 Contraceptives containing 35mg of ethynylestradiol and 2mg of cyproterone acetate cause a significant suppression of gonadotropins and testosterone levels, a reduction in the number of ovarian small follicles as well as a significant reduction in AMH levels. 9 On the other hand, gonadotropinreleasing hormone (GnRH) agonists do not seem to affect AMH concentrations.…”

Section: Amh: Production Levels and Actions In Womenmentioning

confidence: 99%

“…9 Contraceptives containing 35mg of ethynylestradiol and 2mg of cyproterone acetate cause a significant suppression of gonadotropins and testosterone levels, a reduction in the number of ovarian small follicles as well as a significant reduction in AMH levels. 9 On the other hand, gonadotropinreleasing hormone (GnRH) agonists do not seem to affect AMH concentrations. 10 Finally, there are no racial differences in the hormone levels between women of comparable age.…”

Section: Amh: Production Levels and Actions In Womenmentioning

confidence: 99%

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

Karkanaki¹,

Vosnakis²,

Panidis³

2011

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Anti-Müllerian hormone (AMH) is a homodimeric glycoprotein, a member of the transforming growth factor-β superfamily. Over the last decade, a large number of studies examining the multiple roles of AMH have been published. AMH levels accurately reflect the ovarian follicular reserve and could, therefore, be considered as an extremely sensitive marker of ovarian aging and a valuable tool in the diagnosis and the recognition of recurrence of granulosa cell tumors. Furthermore, AMH evaluation is of clinical importance in predicting the success of in vitro fertilization (IVF). Additionally, AMH could be a surrogate diagnostic marker of polycystic ovary syndrome in cases in which ultrasonographic examination is not possible. This article is a review of the clinical usefulness of AMH evaluation in the fields of gynecological endocrinology, menopause, gynecological oncology and assisted reproduction. Special reference is made to the possible implications of AMH in the pathogenesis of polycystic ovary syndrome and the relationship between AMH and obesity.

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The impact of oral contraceptives and metformin on anti-Müllerian hormone serum levels in women with polycystic ovary syndrome and biochemical hyperandrogenemia

Abstract: AMH serum levels were significantly decreased under treatment with 35 μg ethinylestradiol plus 2 mg cyproterone acetate, due to decrease in androgens and suppression of gonadotropins.

Cited by 57 publications

References 24 publications

The association between circulating levels of antimüllerian hormone and follicle number, androgens, and menstrual cycle characteristics in young women

The association between circulating levels of antimüllerian hormone and follicle number, androgens, and menstrual cycle characteristics in young women

Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism

The clinical significance of anti-Müllerian hormone evaluation in gynecological endocrinology

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