The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis

Cai, Chenxi; Vandermeer, Ben; Khurana, Rshmi; Nerenberg, Kara; Featherstone, Robin; Sebastianski, Meghan; Davenport, Margie H.

doi:10.1016/j.ajog.2019.06.051

Cited by 179 publications

(169 citation statements)

References 95 publications

Supporting

Mentioning

150

Contrasting

Unclassified

Order By: Relevance

“…Among those articles, 41 (85%) used shift work as the exposure, and 12 (25%) used long work hours. The articles covered the following outcomes: cancers [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] (16, 33%), cardiovascular disease [33][34][35][36][37][38][39][40][41] (9, 19%), metabolic syndrome, diabetes mellitus, and obesity [42][43][44][45][46][47][48][49][50] (9, 19%), complications of pregnancy [51][52][53][54][55][56][57][58] (8, 17%), depression [43,45,59] (4, 8%), hypertension [60] (1, 2%), and injuries [61] (1, 2%). Some conditions we identified to be chronic or high cost (e.g.…”

Section: Overview Of Search Resultsmentioning

confidence: 99%

“…Fixed shifts were associated with gestational hypertension (OR = 1.19, 95%CI: 1.1 to 1.29, I 2 = 0%) and there was a trend towards significance between rotating shift and gestational hypertension (OR = 1.19, 95%CI: 0.97 to 1.45, I 2 = 0%). [54] Fixed shifts were also associated with increased risk for preterm delivery (OR = 1.21, 95%CI: 1.03 to 1.42, I 2 = 36%). Rotating shifts, meanwhile, was associated with increased the risk of preterm delivery (OR = 1.13, 95%CI: 1.00 to 1.28, I 2 = 31%), and offspring that are small for gestational age (OR = 1.18, 95%CI: 1.01 to 1.38, I 2 = 0%).…”

Section: Plos Onementioning

confidence: 99%

“…Cai et al (2019) [54] estimated the effects of rotating shifts and fixed night shifts on complications of pregnancy and rated the link between the two types of shift work and gestational hypertension to be low grade. Fixed shifts were associated with gestational hypertension (OR = 1.19, 95%CI: 1.1 to 1.29, I 2 = 0%) and there was a trend towards significance between rotating shift and gestational hypertension (OR = 1.19, 95%CI: 0.97 to 1.45, I 2 = 0%).…”

Section: Plos Onementioning

confidence: 99%

See 2 more Smart Citations

Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses

et al. 2020

View full text Add to dashboard Cite

Background Previous reviews have demonstrated that shift work and long work hours are associated with increased risk for chronic conditions. However, these reviews did not comprehensively assessed the body of evidence, and some were not conducted in a systematic manner. A better understanding of the health consequences of shift work and long work hours will aid in creating policy and practice recommendations. This review revisits the epidemiologic evidence on the association of shift work and long work hours with chronic conditions with particular emphasis on assessing the quality of the evidence. Methods and findings We conducted a systematic review of systematic reviews with meta-analyses (SR-MA) that assessed the link between shift work or long work hours and chronic conditions (PROS-PERO CRD42019122084). We evaluated the risk of bias of each SR-MA using AMSTAR v2 and assessed the overall evidence for each condition using the GRADE approach. We included 48 reviews covering cancers, cardiovascular diseases, metabolic syndrome and related conditions, pregnancy complications, depression, hypertension, and injuries. On average, only 7 of 16 AMSTAR items were fulfilled. Few SR-MAs had a registered protocol and nearly all failed to conduct a comprehensive search. We found moderate grade evidence linking shift work to breast cancer and long work hours to stroke. We found low grade evidence linking both shift work and long work hours with low to moderate increase in risk for some pregnancy complications and cardiovascular diseases. Low grade evidence also link long work hours and depression. Conclusions Moderate grade evidence suggest that shift work and long work hours increase the risk of breast cancer and stroke, but the evidence is unclear on other chronic conditions. There is a

show abstract

Section: Overview Of Search Resultsmentioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

Section: Plos Onementioning

confidence: 99%

See 1 more Smart Citation

Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Epidemiologic studies have revealed an association between gestational chronodisruption and adverse pregnancy outcomes [45][46][47][48][49][50][51][52][53]. The disruption of circadian rhythms in pregnant women can occur through shift work [45][46][47], jet travel across time zones [51,52], or exposure to light at night [48].…”

Section: Human Studies For Programming Of Adult Diseases Related To Mmentioning

confidence: 99%

“…Pregnant flight attendants were shown to have a higher risk of spontaneous abortion and miscarriage when compared to flight attendants who did not work during their pregnancy [51,52]. A meta-analysis of 62 studies with 196,989 women showed that working rotating shifts is associated with preterm delivery, an infant small for gestational age, preeclampsia, and gestational hypertension [53]. Additionally, an association between pregnant women working fixed night shifts and increased odds of preterm delivery and miscarriage was shown [53].…”

Section: Human Studies For Programming Of Adult Diseases Related To Mmentioning

confidence: 99%

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Hsu

Tain

2020

IJMS

View full text Add to dashboard Cite

Light is a crucial environmental signal that affects elements of human health, including the entrainment of circadian rhythms. A suboptimal environment during pregnancy can increase the risk of offspring developing a wide range of chronic diseases in later life. Circadian rhythm disruption in pregnant women may have deleterious consequences for their progeny. In the modern world, maternal chronodisruption can be caused by shift work, jet travel across time zones, mistimed eating, and excessive artificial light exposure at night. However, the impact of maternal chronodisruption on the developmental programming of various chronic diseases remains largely unknown. In this review, we outline the impact of light, the circadian clock, and circadian signaling pathways in pregnancy and fetal development. Additionally, we show how to induce maternal chronodisruption in animal models, examine emerging research demonstrating long-term negative implications for offspring health following maternal chronodisruption, and summarize current evidence related to light and circadian signaling pathway targeted therapies in pregnancy to prevent the development of chronic diseases in offspring.

show abstract

Evaluation of Adverse Pregnancy Outcomes in Physicians Compared With Nonphysicians

et al. 2022

View full text Add to dashboard Cite

Key Points Question Are physicians at an increased risk of adverse pregnancy outcomes compared with nonphysicians? Findings In this cohort study of 10 489 births in 6161 physicians, there was an increased risk of severe maternal morbidity among physicians compared with high-income nonphysicians; however, this association was not found after adjustment for maternal age and other clinical factors. No difference in adverse outcome was observed when comparing physician specialty groups. Meaning The findings of this study suggest that observed associations between physician occupation and pregnancy complications are likely mediated by advanced maternal age rather than the nature of the occupation.

show abstract

The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis

Cited by 179 publications

References 95 publications

Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses

Shift work and long work hours and their association with chronic health conditions: A systematic review of systematic reviews with meta-analyses

Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Evaluation of Adverse Pregnancy Outcomes in Physicians Compared With Nonphysicians

Contact Info

Product

Resources

About