Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Hsu, Chien‐Ning; Tain, You‐Lin

doi:10.3390/ijms21062232

Cited by 45 publications

(43 citation statements)

References 127 publications

(235 reference statements)

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“…Disturbances in the fetal circadian system may trigger long-term consequences. Interference to normal light/dark cycle in late pregnancy or during the perinatal period may have detrimental effects on the behavior and metabolic functions of the offspring, possibly contributing to conditions such as metabolic syndrome, obesity, attention deficit-hyperactivity disorder, or autism spectrum disorders [ 81 , 82 , 83 , 84 ].…”

Section: Melatonin Involvement In Maternal and Fetal Healthmentioning

confidence: 99%

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies.

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Section: Melatonin Involvement In Maternal and Fetal Healthmentioning

confidence: 99%

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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“…Additionally, the NAD pathway is enhanced in pregnant women and rats [ 33 ]. In the serotonin pathway, an adequate supply of serotonin and melatonin is crucial for fetal development [ 34 , 35 , 36 ]. Clinical and experimental evidence support the notion that perinatal selective serotonin reuptake inhibitors (SSRI) exposure can reduce body weight, impair brain development, and cause life-long adverse emotional health [ 37 ].…”

Section: Tryptophan Metabolismmentioning

confidence: 99%

Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism

Hsu

Tain

2020

IJMS

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The concept that hypertension and chronic kidney disease (CKD) originate in early life has emerged recently. During pregnancy, tryptophan is crucial for maternal protein synthesis and fetal development. On one hand, impaired tryptophan metabolic pathway in pregnancy impacts fetal programming, resulting in the developmental programming of hypertension and kidney disease in adult offspring. On the other hand, tryptophan-related interventions might serve as reprogramming strategies to prevent a disease from occurring. In the present review, we aim to summarize (1) the three major tryptophan metabolic pathways, (2) the impact of tryptophan metabolism in pregnancy, (3) the interplay occurring between tryptophan metabolites and gut microbiota on the production of uremic toxins, (4) the role of tryptophan-derived metabolites-induced hypertension and CKD of developmental origin, (5) the therapeutic options in pregnancy that could aid in reprogramming adverse effects to protect offspring against hypertension and CKD, and (6) possible mechanisms linking tryptophan metabolism to developmental programming of hypertension and kidney disease.

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“…Moreover, in addition to these acute changes, it is necessary to consider the epigenetic consequences of the changed lighting environment. Several animal experiments indicate that exposure of pregnant female mice to unstable light/dark conditions may have long-lasting effects on their progeny [ 38 , 39 ]. In contrast to the short-lasting consequences of acute exposure to ALAN, in utero effects are mediated by epigenetic mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Impact of Dim Light at Night on Urinary 6-Sulphatoxymelatonin Concentrations and Sleep in Healthy Humans

Stebelová

Roška

Zeman

2020

IJMS

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Artificial light at night can have negative effects on human wellbeing and health. It can disrupt circadian rhythms, interfere with sleep, and participate in the progress of civilisation diseases. The aim of the present study was to explore if dim artificial light during the entire night (ALAN) can affect melatonin production and sleep quality in young volunteers. We performed two experiments in real-life home-based conditions. Young volunteers (n = 33) were exposed to four nights of one lux ALAN or two nights of five lux ALAN. Melatonin production, based on 6-sulphatoxymelatonin/creatinine concentrations in urine, and sleep quality, based on actimetry, were evaluated. Exposure to ALAN one lux during the entire night did not suppress aMT6s/creatinine concentrations but did aggravate sleep quality by increasing sleep fragmentation and one-minute immobility. ALAN up to five lux reduced melatonin biosynthesis significantly and interfered with sleep quality, as evidenced by an increased percentage of one-minute immobility and a tendency of increased fragmentation index. Our results show that people are more sensitive to low illuminance during the entire night, as previously expected. ALAN can interfere with melatonin production and sleep quality in young, healthy individuals, and both processes have different sensitivities to light.

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Light and Circadian Signaling Pathway in Pregnancy: Programming of Adult Health and Disease

Cited by 45 publications

References 127 publications

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism

Impact of Dim Light at Night on Urinary 6-Sulphatoxymelatonin Concentrations and Sleep in Healthy Humans

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