The Impact of Neoadjuvant Chemotherapy on Patients with Locally Advanced Breast Cancer in a Nigerian Semiurban Teaching Hospital: A Single‐center Descriptive Study

Abstract

There was a poor overall clinical response rate to neoadjuvant chemotherapy in the Black population studied. Late presentation with large tumor mass may be accountable for this.

Cancer incidence in Nigeria: A report from population-based cancer registries

“…It has been reported in the literature that high numbers of patients diagnosed clinically is an indicator of late diagnosis or lack of resources in the country [22] and advanced stage at presentation is a common finding in Nigerian cancer patients. [23; 24]…”

How Effective is the Treatment of Locally Advanced and Metastatic Breast Cancer in Developing Centres?: A Retrospective Review

“…He compared the figures with those obtained in the developed countries about half a century earlier (in the 1940s). Today, figures quoted in Nigeria and some other developing countries are not distinctly different from chiedozi's (5,7,8,11,12) . Does this mean that despite worldwide improvements in cancer care, our results still remain at par with the results obtained in the developed countries in the late 1940s?…”

“…Therefore, the thoughts held by the proponentsof McKinnon have abated. In developing countries, 8o% of breast cancer patients present late, and the outcome of management can begenerally described as gloom (6)(7)(8)(9)(10)(11). Consequently, it is natural for some clinitians to be worried by the thoughts held by the advocatesof McKinnon more than half a century ago.…”

“…The biology of breast cancer differs between Caucasians and Africans; the pattern of presentation, facilities for diagnosis, treatment and the response to treatment also differ (8,11,12). Despite these facts, many literatures from developing countries commonly appraise the outcomes of their patient management in the light of the results obtained in developed countries.…”

Mammographic Breast Density: Comparison Across Women with Conclusive and Inconclusive Mammography Reports

“…Mammography is the standard tool for early detection and is performed for screening (asymptomatic) or diagnostic (symptomatic) purposes. However, screening mammography has not gained popularity in Nigeria [7][8][9][10], and women in this region present late and are diagnosed clinically at advanced stages of the disease [11]. Hence, late detection of breast cancer has been implicated with increased mortality from the disease in Nigeria and Africa at large [12].…”