The impact of neck and abdominal fat accumulation on the pathogenesis of obstructive sleep apnea

Franco, Inês; Reis, Roberto Palma dos; Ferreira, Daniela; Xará, Sónia; Ferreira, Wilson; Bettencourt, Nuno; Antunes, Ana

doi:10.1016/j.rppnen.2016.01.007

Cited by 3 publications

(4 citation statements)

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“…However, there are mixed reports on better correlates, with few studies showing neck circumference as better correlated with AHI [23, 24, 39, 40], and others showing waist circumference as a better correlate [22, 41], findings which are consistent with our study. In addition, there are a few studies where BMI values are better correlates of AHI than waist and neck circumferences [42, 43]. In the midst of different anthropologic measures, our findings suggest that waist circumference to be better correlated with OSA symptoms and severity among three measures i.e.…”

Section: Discussionmentioning

confidence: 52%

Correlations Between Waist and Neck Circumferences and Obstructive Sleep Apnea Characteristics

et al. 2018

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PURPOSE The body mass index (BMI), an estimate of body fat, provides a rather imprecise indication of risk for obstructive sleep apnea (OSA). We examined whether other measures, including waist and neck circumference, provide improved indicators of risk in treatment-naïve OSA subjects. METHODS We studied 59 OSA subjects [age, 48.8±10.0 years; BMI, 31.9±6.6 kg/m2; apnea-hypopnea-index (AHI), 38.5±23.0 events/hour; sleep efficiency index (SEI, n=52), 78.6±14.4%; lowest oxygen saturation (SaO2 nadir), 79.5±8.0%; systolic blood pressure (BP), 127.4±15.7 mmHg; diastolic BP, 80.1±9.1 mmHg; 43 male), and determined waist and neck circumferences (waist, 107.4±15.3 cm; neck, 41.8±4.7 cm), daytime sleepiness [Epworth sleepiness scale (ESS), 8.7±4.6], sleep quality [Pittsburgh sleep quality index (PSQI), 8.5±4.1], depression levels [Beck depression inventory II (BDI-II), 6.6±5.7), and anxiety levels [Beck anxiety inventory (BAI), 6.2±7.2]. We used partial correlation procedures (covariates, age and gender) to examine associations between BMI, waist, and neck circumferences vs. AHI, sleep, and neuropsychological variables. RESULTS BMI, waist, and neck circumferences were significantly correlated with SaO2 nadir (BMI; r=−0.423, p=0.001; waist; r=−0.457, p<0.001; neck; r=−0.263, p=0.048), AHI (BMI; r=0.349, p=0.008; waist; r=0.459, p<0.001; neck; r=0.276, p=0.038), and systolic BP (BMI; r=0.354, p=0.007; waist; r=0.321, p=0.015; neck; r=0.388, p=0.003). SEI was significantly correlated with waist circumference (r=0.28, p=0.049), but higher with BMI (r=0.291, p=0.04). CONCLUSIONS No other significant waist or neck correlations emerged. This study suggests that waist and neck measures correlate better than BMI with select disease severity (SaO2 nadir and AHI) in OSA subjects. The findings offer an easily-measured, ancillary means to assess OSA risk.

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Section: Discussionmentioning

confidence: 52%

Correlations Between Waist and Neck Circumferences and Obstructive Sleep Apnea Characteristics

et al. 2018

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“…21,22 Patients with confirmed OSA have larger soft tissue structures surrounding the upper airway, including lateral pharyngeal walls and greater tongue fat volume compared to patients without OSA. 23 Our study has limitations. Retrospective design carried the typical associated restrictions.The smaller sample in normal-weight group difficult comparisons and limit our interpretation.…”

Section: Discussionmentioning

confidence: 89%

“… 21 22 Patients with confirmed OSA have larger soft tissue structures surrounding the upper airway, including lateral pharyngeal walls and greater tongue fat volume compared to patients without OSA. 23 …”

Section: Discussionmentioning

confidence: 99%

The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA

Ernst,

Dalzotto,

Saban

et al. 2023

Sleep Sci

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Objective Obstructive sleep apnea (OSA) is a disorder characterized by recurrent pharyngeal obstruction during sleep, in which upper airway anatomy plays a key role in its pathogenesis. The aim of this study was to describe whether the quantification of cervical fat tissue volume (CFTV) obtained by Computed Tomography (CT)cephalometry is related to the severity of OSA. Methods Retrospective study between 2018 and 2020 in those patients > 18 years old, with diagnosis of OSA who performed a volumetric cephalometric imaging. Three-dimensional reconstruction of the images was performed and CFTV was measured. Results 91 patients were included in this study of which: without OSA (n: 7), mild (n: 19), moderate (n: 39) and severe OSA (n: 26). We observed a progressive increase of CFTV related to OSA severity has been observed (without OSA: 58.9 ml (47.9-87.5), mild: 59.1ml (48.4-78.3), moderate: 71 ml (42.6-127.1) and severe OSA 103.6 ml (81-153); p < 0.01); nevertheless, no differences were found in the airway volume and neck area. It was showed a significant correlation between CFTV and OSA indicators: AHI, ODI and T90 (Sp r: 0.48; 0.38 and 0.36; p < 0.01 respectively). CFTV cut-off value to discriminate AHI >15 ev/h with best sensitivity-specificity relationship was 64.1 ml with an area under the curve of 0.6 ± 0.06. Multivariate analysis showed that CFTV is a predictor for moderate to severe OSA (OR:3.05, IC95%: 1.14-8.17). Conclusion Cervical fat quantification by CT cephalometry correlates with OSA severity in adults. Fat volume > 64.1 ml increased more than three times the risk of OSA moderate to severe.

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“…15 Oleh karena itu, faktor anatomis seperti indeks massa tubuh, lingkar leher, lingkar lengan, dan lingkar perut sudah diteliti menunjukkan hubungan yang bermakna sebagai faktor risiko terjadinya OSA. [16][17][18] Namun di Indonesia penelitian ini masih terbatas dan jarang menggunakan PSG sebagai pemeriksaan baku emas OSA, sehingga umumnya hanya menggunakan skoring prediktor OSA, seperti yang diteliti oleh Wiadnyana dkk atau oleh Priscilla dkk. [19][20] Penelitian tentang faktor risiko OSA terpublikasi dengan menggunakan PSG baru dilakukan oleh Susanto.…”

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Hubungan Ukuran Antropometri Dengan Derajat Obstructive Sleep Apnea

Tori

Suryawati

Husni

2018

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CORRELATION BETWEEN ANTHROPOMETRIC MEASUREMENTS AND STAGE OF OBSTRUCTIVE SLEEP APNEAABSTRACKIntroduction: Obstructive sleep apnea (OSA) is estimated to occur 2-10% worldwide and associated with various diseases. OSA severity can be assessed by apnea hypopnea index (AHI). Increased anthropometric measurements indicate increased thickness of fatty tissue in the neck, as well as fatty deposits of the abdomen which can cause constriction of the airways. Other variables suspected to have an effect on AHI are age, sex, smoking habit, and Mallampati score.Aims: To analyze the correlation between anthropometric measurements and OSA severity.Methods: Descriptive analytic studies on OSA patients treated at Dr. Kariadi Hospital, Semarang, January- August 2017. Subjects were included in the study if STOPBANG score was >2. Anthropometric measurements (body mass index, neck circumference, abdominal circumference) was performed on the basis of the International Organization for Standardization (ISO) method while AHI was measured with polysomnography.Results: Bivariate correlation test on 23 subjects showed significant correlation between OSA severity with body mass index (BMI) and neck circumference but no significant correlation with abdominal circumference. Multivariate test showed the most influential variable was BMI.Discussion: There were significant correlations between anthropometric measurements (BMI and neck circumference) with OSA severity.Keywords: Abdominal circumference, apnea hypopnea index, body mass index, neck circumference, obstructive sleep apneaABSTRAKPendahuluan: Obstructive sleep apnea (OSA) diperkirakan terjadi 2-10% di seluruh dunia yang berkaitan dengan berbagai macam penyakit. Derajat OSA dinilai dengan indeks apnea-hypopnea (apnea hypopnea index/AHI). Tingginya nilai antropometri tubuh menandakan tebalnya jaringan lemak pada leher, demikian pula deposit lemak pada abdomen dapat menyebabkan penyempitan pada saluran napas. Variabel lain yang diduga berpengaruh terhadap AHI adalah usia, jenis kelamin, kebiasaan merokok, dan skor Mallampati.Tujuan: Menganalisis hubungan ukuran antropometri dengan derajat OSA.Metode: Studi deskriptif analitik secara potong lintang dilakukan terhadap pasien dengan OSA di RSUP Dr. Kariadi, Semarang, pada bulan Januari-Agustus 2017. Kriteria inklusi adalah pasien yang dicurigai OSA berdasarkan skor STOPBANG >2. Pemeriksaan antropometri (indeks massa tubuh/IMT, lingkar leher, dan lingkar perut) berdasarkan metode dari ISO (the International Organization for Standardization), sedangkan pemeriksaan AHI menggunakan polisomnografi.Hasil: Uji korelasi bivariat terhadap 23 subjek menunjukkan hubungan bermakna antara derajat OSA dengan IMT dan lingkar leher, namun tidak berhubungan dengan lingkar perut. Uji multivariat menunjukkan variabel yang paling berhubungan dengan derajat OSA adalah IMT.Diskusi: Terdapat hubungan bermakna antara ukuran antropometri (IMT dan lingkar leher) dengan derajat OSA.Kata kunci: Apnea hypopnea index, indeks massa tubuh, lingkar leher, lingkar perut, obstructive sleep apnea

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The impact of neck and abdominal fat accumulation on the pathogenesis of obstructive sleep apnea

Cited by 3 publications

References 9 publications

Correlations Between Waist and Neck Circumferences and Obstructive Sleep Apnea Characteristics

Correlations Between Waist and Neck Circumferences and Obstructive Sleep Apnea Characteristics

The Cervical Fat Tissue Volume is a Predictor for Moderate to Severe OSA

Hubungan Ukuran Antropometri Dengan Derajat Obstructive Sleep Apnea

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