The impact of menstrual cycle phase on cardiac autonomic regulation

McKinley, Paula S.; King, Anthony; Shapiro, Peter A.; Slavov, I; Fang, Yixin; Chen, Ivy S.; Jamner, Larry D.; Sloan, Richard P.

doi:10.1111/j.1469-8986.2009.00811.x

Cited by 65 publications

(63 citation statements)

References 41 publications

(62 reference statements)

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“…The BP response to sodium loading is not affected by the menstrual cycle in young women, nor is it influenced by the use of oral contraceptives [41,42]. We did study all women in the follicular phase, which has been shown to be associated with lower HR, higher SDNN and RMSSD, high frequency and low frequency than during the luteal phase, irrespective of sodium [43]. Together with our findings, it remains unclear whether dietary sodium interacts with HRV at various points in the menstrual cycle.…”

Section: Discussionmentioning

confidence: 92%

Dietary sodium influences the effect of mental stress on heart rate variability

Allen¹,

Gullixson²,

Wolhart³

et al. 2014

Journal of Hypertension

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Section: Discussionmentioning

confidence: 92%

Dietary sodium influences the effect of mental stress on heart rate variability

Allen¹,

Gullixson²,

Wolhart³

et al. 2014

Journal of Hypertension

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“…Previous and recent studies have demonstrated that both salt intake [6,24] and the normal menstrual cycle in women [2,23,26] can affect autonomic circulatory control. We also found recently that menstrual cycle can affect sympathetic neural responses during orthostasis in young healthy women [10].…”

Section: Autonomic Circulatory Control In Potsmentioning

confidence: 99%

Effects of exercise training on arterial-cardiac baroreflex function in POTS

et al. 2010

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Purpose Postural orthostatic tachycardia syndrome (POTS) is characterized by excessive tachycardia in the upright position. To test the hypothesis that patients with POTS have impaired arterial-cardiac baroreflex function, while exercise training normalizes the baroreflex function in these patients. Methods Seventeen POTS patients aged 27 ± 9 (mean ± SD) years underwent an exercise training program for 3 months. Arterial-cardiac baroreflex function was assessed by spectral and transfer function analysis of beat-tobeat R-R interval (RRI) and systolic blood pressure (SBP) variability in the supine position and at 60°upright tilt during spontaneous breathing before and after training. Data were compared with 17 healthy sedentary controls. Results Even though upright heart rate (HR) was greater in patients than controls, indexes of RRI variability did not differ between groups. Transfer function gain (SBP to RRI), used as an index of arterial-cardiac baroreflex sensitivity was similar between patients and controls in both low-(LF, P = 0.470) and high-frequency (HF, P = 0.663) ranges. Short-term exercise training decreased upright HR and increased RRI variability in POTS patients. LF baroreflex gain increased significantly in the supine position and during upright tilt [analysis of variance (ANOVA), P = 0.04 for training], while HF gain increased modestly after training (ANOVA, P = 0.105 for training) in these patients; however, the baroreflex gains remained within the normal ranges when compared with healthy controls. Conclusions These data suggest that patients with POTS have normal arterial-cardiac baroreflex function in both supine and upright postures. Short-term exercise training increases the baroreflex sensitivity in these patients, associated with a decrease in upright heart rate.

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“…These data will be reported elsewhere. Women were scheduled for testing during their midluteal menstrual phase to control for the effects of menstrual cycle variation on cardiac autonomic control, as described below 27. Those who completed this measurement session were randomized to either the 12‐week aerobic training program or a wait‐list control condition using random block assignment stratified by sex.…”

Section: Methodsmentioning

confidence: 99%

Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults

Sloan

Shapiro

McKinley

et al. 2018

JAHA

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BackgroundConsensus panels regularly recommend aerobic exercise for its health‐promoting properties, due in part to presumed anti‐inflammatory effects, but many studies show no such effect, possibly related to study differences in participants, interventions, inflammatory markers, and statistical approaches. This variability makes an unequivocal determination of the anti‐inflammatory effects of aerobic training elusive.Methods and ResultsWe conducted a randomized controlled trial of 12 weeks of aerobic exercise training or a wait list control condition followed by 4 weeks of sedentary deconditioning on lipopolysaccharide (0, 0.1, and 1.0 ng/mL)‐inducible tumor necrosis factor‐α (TNF‐α) and interleukin‐6 (IL‐6), and on toll‐like receptor 4 in 119 healthy, sedentary young adults. Aerobic capacity by cardiopulmonary exercise testing was measured at study entry (T1) and after training (T2) and deconditioning (T3). Despite a 15% increase in maximal oxygen consumption, there were no changes in inflammatory markers. Additional analyses revealed a differential longitudinal aerobic exercise training effect by lipopolysaccharide level in inducible TNF‐α (P=0.08) and IL‐6 (P=0.011), showing T1 to T2 increases rather than decreases in inducible (lipopolysaccharide 0.1, 1.0 versus 0.0 ng/mL) TNF‐α (51% increase, P=0.041) and IL‐6 (42% increase, P=0.11), and significant T2 to T3 decreases in inducible TNF‐α (54% decrease, P=0.007) and IL‐6 (55% decrease, P<0.001). There were no significant changes in either group at the 0.0 ng/mL lipopolysaccharide level for TNF‐α or IL‐6.ConclusionsThe failure to support the primary hypotheses and the unexpected post hoc findings of an exercise‐training–induced proinflammatory response raise questions about whether and under what conditions exercise training has anti‐inflammatory effects.Clinical Trial Registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01335737.

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The impact of menstrual cycle phase on cardiac autonomic regulation

Cited by 65 publications

References 41 publications

Dietary sodium influences the effect of mental stress on heart rate variability

Dietary sodium influences the effect of mental stress on heart rate variability

Effects of exercise training on arterial-cardiac baroreflex function in POTS

Aerobic Exercise Training and Inducible Inflammation: Results of a Randomized Controlled Trial in Healthy, Young Adults

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