The Impact of Low-Level Laser Therapy on Oral Mucositis and Quality of Life in Patients Undergoing Hematopoietic Stem Cell Transplantation Using the Oral Health Impact Profile and the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation Questionnaires

Silva, Lorrany Candido; Sacono, Nancy Tomoko; Freire, Maria do Carmo Matias; Costa, Luciane Rezende; Batista, Aline Carvalho; Silva, Geisa Badauy Lauria

doi:10.1089/pho.2015.3911

Cited by 27 publications

(13 citation statements)

References 25 publications

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“…It is added that, in another study, Silva et al, (2014) [25], observed that 72.8% of patients on preventive laser therapy protocol also did not developed the condition. It is emphasized that, among the patients evaluated in the present study who presented mucositis, most were classified in grade 1, where there is no ulcer, as observed in the works by Silva et al, (2015) [26] and Bezinelli et al, (2015) [3], who evaluated patients under a preventive protocol.…”

Section: Discussionsupporting

confidence: 63%

“…The most used preventive protocol was Laser V, 2J, 20sec, although the protocols are quite variable in the literature, which is a major limitation for the establishment of an effective standard protocol for the prevention of oral mucositis. Even so, there is a certain standardization for the use of red spectrum laser for prevention [23,26,29,30].…”

Section: Discussionmentioning

confidence: 99%

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Incidence and Risk Factors for Oral Mucositis After Bone Marrow Transplantation Patients Under Low Intensity Laser Therapy: A Longitudinal Study

Malta

Rodrigues

Lemos

et al. 2020

jbmtct

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Bone marrow transplantation (BMT) has been used to treat numerous malignant and non-malignant hematological diseases, genetic and immunological diseases with a high risk of oral mucositis (OM) due to the action of antineoplastic drugs. As photobiomodulation therapy (FBMT) with low-level laser is a proven non-invasive treatment for OM, the objective of this study was to evaluate the incidence of OM in patients on BMT undergoing FBM. 53 patients undergoing treatment received FBMT (red laser, 2J, 20s, 100mW) as a preventive protocol. If MO was observed, an infrared laser (4J, 40s, 100W) was administered. The following data were collected from patients' medical records: sex, age, chemotherapy protocol (QT) and type of BMT. An incidence of 34% was observed in the population studied (20% grade I, 11.3% grade II and 1.9% grade III). Prevention protocols using FBMT significantly reduced the incidence of oral mucositis (p = 0.004). Now, young patients with myeloid leukemia, the time between QT and BMT (p = 0.010) and time of QT (p = 0.018) were directly associated with the increased incidence of oral mucositis. It was concluded that low-intensity preventive laser therapy was associated with a reduction in the incidence of oral mucositis, showing the importance of this therapy in the management of patients undergoing BMT.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Incidence and Risk Factors for Oral Mucositis After Bone Marrow Transplantation Patients Under Low Intensity Laser Therapy: A Longitudinal Study

Malta

Rodrigues

Lemos

et al. 2020

jbmtct

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“…Additionally, data gained can introduce a comparison between the two instruments, as our literature review did not reveal any study comparing data from the OHIP-14 and the FACT-Head and Neck instruments. There was however, one study found which compared OHIP-14 to another member of the FACIT family, namely the FACT-Bone Marrow Transplant [13].…”

Section: Comparison Of Quality Of Life Instrumentsmentioning

confidence: 99%

Preradiotherapy dental extractions and health-related quality of life

Beech

Porceddu

Batstone

2016

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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word count: 188 Manuscript word count: 3587 Number of references: 25 Number of tables: 7 AbstractBackground: Health-related quality of life (HRQoL) is a valuable outcome measurement of treatment, particularly in patients undergoing therapy for malignancy. Due to the effects of both disease and treatment, it is important for clinicians to understand the holistic experience of the patient, not just the direct physical effect on morbidity and mortality. Oropharyngeal cancers are often treated with radiation to the head and neck, which presents a number of issues that will affect quality of life, including difficult to manage sequelae such as osteoradionecrosis. Dental extractions performed under any circumstances have an impact on quality of life, and those performed pre and post-radiotherapy are no exception. Aim: The aim of this study was to investigate the connection between preradiotherapy dental extractions and self-reported health related quality of life. Methods: Retrospective data on patients treated with radiotherapy for oropharyngeal cancer were pooled with a cross-sectional survey. Results: greater than 8 pre-radiotherapy dental extractions, p16 negative status, female gender and positive smoking status were associated with statistically significant reduced quality of life. Conclusion: pre-radiotherapy dental extractions do not result in improved quality of life, and may in fact worsen it.

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“…La TLBI actúa principalmente sobre el citocromo c-oxidasa, flavinas y las porfirinas las cuales absorben ciertas longitudes de ondas (rojas-infrarrojas),que resulta en la producción de energía para desarrollar los procesos metabólicos de las células, mejorar la microcirculación, aumentar la proliferación y movilidad de las celulas epiteliales y fibroblastos para que aceleren la síntesis de colágeno y así disminuir las especies reactivas de oxígeno. Estudios recientes sugieren que la TLBI activa factores de transcripción, citoquinas y quimioquinas, generando un mecanismo de protección en los tejidos, aumentando los niveles de citoquinas antiinflamatorios como (IL-10) (Silva et al, 2015).…”

Section: Introductionunclassified

Mucositis Oral: Actualización en el Diagnóstico, Prevención y Tratamiento

Navarro-Wike

Leiva-Contreras

Donoso-Hofer

2021

Int. J. Odontostomat.

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RESUMEN: La mucositis oral (MO) es la reacción secundaria aguda más frecuente en la cavidad oral y tracto gastrointestinal en pacientes oncológicos sometidos a quimioterapia o radioterapia de cabeza y cuello que incide negativamente en la calidad de vida del paciente. Su tratamiento requiere de un manejo multidisciplinario con el objetivo de minimizar la incidencia y severidad de esta patología. El desconocimiento parcial respecto de su etiopatogenia imposibilita la realización de protocolos para el manejo de esta complicación. Si bien existe evidencia científica respecto a las alternativas de prevención y tratamiento, éstas dependen de la evaluación individual que haga el clínico con cada paciente. A continuación, se presenta una revisión bibliográfica actualizada de la literatura científica publicada y se discuten aquellos aspectos más relevantes en torno a la prevención y tratamiento de la mucositis oral.

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The Impact of Low-Level Laser Therapy on Oral Mucositis and Quality of Life in Patients Undergoing Hematopoietic Stem Cell Transplantation Using the Oral Health Impact Profile and the Functional Assessment of Cancer Therapy-Bone Marrow Transplantation Questionnaires

Abstract: LLLT did not influence the oral and general health-related QoL of patients undergoing HSCT, although it was clinically effective in reducing the severity of chemotherapy-induced OM.

Cited by 27 publications

References 25 publications

Incidence and Risk Factors for Oral Mucositis After Bone Marrow Transplantation Patients Under Low Intensity Laser Therapy: A Longitudinal Study

Incidence and Risk Factors for Oral Mucositis After Bone Marrow Transplantation Patients Under Low Intensity Laser Therapy: A Longitudinal Study

Preradiotherapy dental extractions and health-related quality of life

Mucositis Oral: Actualización en el Diagnóstico, Prevención y Tratamiento

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