The impact of intraoperative propofol administration in the prevention of postoperative pruritus induced by epidural morphine

Kostopanagiotou, Georgia; Pandazi, Ageliki; Matiatou, Stamo; Kontogiannopoulou, S.; Matsota, Paraskevi; Niokou, Dimitra; Kitsou, Maria-Chrysanthi; Crepi, E.; Christodoulaki, Kalliopi; Grigoropoulou, I.

doi:10.1017/s0265021505001912

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…In man, propofol has been reported to be an effective treatment for pruritus associated with epidural or intrathecal opioids (Horta et al 2006;Kostopanagiotou et al 2006). However, a meta-analysis by Kjellberg and Tramèr (2001) of 22 trials in 1477 patients reported no evidence of antipruritic efficacy of prophylactic propofol.…”

Section: Discussionmentioning

confidence: 99%

Pruritus in two horses following epidurally administered morphine

Kalchofner

Kummer

Price

et al. 2007

Equine Veterinary Education

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Section: Discussionmentioning

confidence: 99%

Pruritus in two horses following epidurally administered morphine

Kalchofner

Kummer

Price

et al. 2007

Equine Veterinary Education

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“…This observation could be partially attributed to the antioxidative capability of mannitol. [46][47][48] Typical phase and uorescence images showing the formation of a single cell aggregate of uniform size in each ACA microcapsule with high cell viability aer 7 day culture of the Journal of Materials Chemistry B Paper encapsulated ES cells in complete ES cell medium are given in Fig. 2C and D, respectively.…”

Section: Capability Of the Aca Microcapsule For Encapsulating And Cul...mentioning

confidence: 99%

A novel core–shell microcapsule for encapsulation and 3D culture of embryonic stem cells

et al. 2013

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In this study, we report the preparation of a novel microcapsule of ~ 100 μm with a liquid (as compared to solid-like alginate hydrogel) core and an alginate-chitosan-alginate (ACA) shell for encapsulation and culture of embryonic stem (ES) cells in the miniaturized 3D space of the liquid core. Murine R1 ES cells cultured in the microcapsules were found to survive (> 90%) well and proliferate to form either a single aggregate of pluripotent cells or embryoid body (EB) of more differentiated cells in each microcapsule within 7 days, dependent on the culture medium used. This novel microcapsule technology allows massive production of the cell aggregates or EBs of uniform size and controllable pluripotency, which is important for the practical application of stem cell based therapy. Moreover, the semipermeable ACA shell was found to significantly reduce immunoglobulin G (IgG) binding to the encapsulated cells by up to 8.2 times, compared to non-encapsulated cardiac fibroblasts, mesenchymal stem cells, and ES cells. This reduction should minimize inflammatory and immune responses induced damage to the cells implanted in vivo becasue IgG binding is an important first step of the undesired host responses. Therefore, the ACA microcapsule with selective shell permeability should be of importance to advance the emerging cell-based medicine.

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“…It exerts its antipruritic action through the inhibition of the posterior horn transmission in the spinal cord. [1148495051525354] Many studies have been carried out with the sub-hypnotic propofol doses ranging from 10 mg bolus to 30 mg over 24 h, but results were conflicting. [51125]…”

Section: Introductionmentioning

confidence: 99%

Neuraxial opioid-induced pruritus: An update

Kumar

Singh

2013

J Anaesthesiol Clin Pharmacol

136

115

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Pruritus is a troublesome side-effect of neuraxial (epidural and intrathecal) opioids. Sometimes it may be more unpleasant than pain itself. The prevention and treatment still remains a challenge. A variety of medications with different mechanisms of action have been used for the prevention and treatment of opioid-induced pruritus, with mixed results. The aim of this article is to review the current body of literature and summarize the current understanding of the mechanisms and the pharmacological therapies available to manage opioid-induced pruritus. The literature source of this review was obtained via PubMed, Medline and Cochrane Database of Systematic Reviews until 2012. The search results were limited to the randomized controlled trials, systemic reviews and non-systemic reviews.

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The impact of intraoperative propofol administration in the prevention of postoperative pruritus induced by epidural morphine

Abstract: Propofol-based general anaesthesia compared to thiopental-sevoflurane-based anaesthesia reduces the incidence and severity of pruritus induced by a single injection of 3 mg epidural morphine with ropivacaine.

Cited by 12 publications

References 13 publications

Pruritus in two horses following epidurally administered morphine

Pruritus in two horses following epidurally administered morphine

A novel core–shell microcapsule for encapsulation and 3D culture of embryonic stem cells

Neuraxial opioid-induced pruritus: An update

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