The impact of insect growth regulators on adult emergence inhibition and the fitness of Aedes aegypti field populations in Thailand

Fansiri, Thanyalak; Pongsiri, Arissara; Khongtak, Patcharee; Nitatsukprasert, Chanyapat; Chittham, Wachiraphan; Jaichapor, Boonsong; Pathawong, Nattaphol; Kijchalao, Udom; Tiangtrong, Somsak; Singkhaimuk, Preeraya; Ponlawat, Alongkot

doi:10.1016/j.actatropica.2022.106695

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Fertility reduction in the male mosquito population could subsequently impact the viable hatching embryos in females if they were to mate with PPF-exposed males. These results are similar to those of a previous study that observed a significant reduction in sperm production in the PPF-treated laboratory-reared population compared with field populations in Thailand ( 35 ). The PPF-induced reduction in male fertility could be interpreted as a semi-sterilization effect.…”

Section: Discussionsupporting

confidence: 91%

The impact of non-lethal doses of pyriproxyfen on male and female Aedes albopictus reproductive fitness

Kancharlapalli,

Brelsfoard

2024

Front. Insect Sci.

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IntroductionControl of the mosquito Aedes albopictus is confounded by its behavior due to females preferring to oviposition in small natural and artificial containers that are often difficult to remove or treat with insecticides. Autodissemination strategies utilizing highly potent insect growth regulators (IGRs) have emerged as promising tools for the control of this container-inhabiting species. The intended goal of autodissemination approaches is to use mosquitoes to self-deliver an IGR to these cryptic oviposition locations. Previous studies have focused on the efficacy of these approaches to impact natural populations, but little focus has been placed on the impacts on mosquitoes when exposed to non-lethal doses of IGRs similar to the levels they would be exposed to with autodissemination approaches.MethodsIn this study, the impact of non-lethal doses of pyriproxyfen (PPF) on the reproductive fitness of Ae. albopictus was investigated. Female and male Ae. albopictus mosquitoes were exposed to non-lethal doses of PPF and their fecundity and fertility were measured. To examine the impact of non-lethal doses of PPF, the expression of the ecdysone-regulated genes USP, HR3, and Vg, which are involved in vitellogenesis, was determined.ResultsOur results demonstrated a significant reduction in female fecundity and in the blood feeding and egg hatching rates upon exposure to non-lethal doses of PPF. Oocyte development was also delayed in PPF-treated females. Furthermore, exposure to non-lethal doses of PPF altered the expression of the genes involved in vitellogenesis, indicating disruption of hormonal regulation. Interestingly, PPF exposure also reduced the sperm production in males, suggesting a potential semi-sterilization effect.DiscussionThese findings suggest that non-lethal doses of PPF could enhance the efficacy of autodissemination approaches by impacting the reproductive fitness of both males and females. However, further research is needed to validate these laboratory findings in field settings and to assess their practical implications for vector control strategies.

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Section: Discussionsupporting

confidence: 91%

The impact of non-lethal doses of pyriproxyfen on male and female Aedes albopictus reproductive fitness

Kancharlapalli,

Brelsfoard

2024

Front. Insect Sci.

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“…In the larval bioassay, juvenile hormone analogues such as Pyriproxyfen offer excellent potential for controlling Ae. aegypti larvae by preventing their successful development into viable adults (Fansiri et al 2022). In addition, Pyriproxyfen is considered as a pesticide that is non-toxic to birds or animals, with no genotoxic or carcinogenic effects (Suman et al 2014).…”

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confidence: 99%

Regionality in vector control: effect of fluctuating temperature in the susceptibility of Aedes aegypti (Diptera: Culicidae) larvae to Pyriproxyfen

Moura,

Corbi

2023

Parasitol Res

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Using Pyriproxyfen to control Aedes aegypti populations shows great potential considering its high competence in low dosages and environmental safety. As an endocrine disruptor, temperature can interfere in its e ciency, related to a decrease in larval emergence inhibition in hotter environments.However, previous studies have been performed at constant temperatures in the laboratory, which may not precisely re ect the environmental conditions in the eld. This study aimed to assess the effect of the uctuating temperatures in pyriproxyfen e ciency on controlling Aedes aegypti larvae. We selected maximum and minimum temperatures from the Brazilian Meteorological Institute database from September to April for cities grouped by ve regions. Five uctuating temperatures (17-26; 20-28.5; 23-32.5; 23-30.5; 19.5-31 ºC) were applied to bioassays assessing Pyriproxyfen e ciency in preventing adult emergence in Aedes aegypti larvae in ve concentrations. The proportion of emergence inhibition was compared among treatments and within treatment. In thermal conditions with the lowest temperatures, Pyriproxyfen was e cient to prevent the emergence of twice the larvae than in the hottest temperatures with the lowest concentration applied (average ± SD: 0.61 ± 0.09 in coldest treatment; average ± SD: 0.65 ± 0.12 in the hottest treatment, p value = 0.00015). The concentration that inhibits the emergence of 50% of the population was lower than that preconized by the World Health Organization (0.01 mg/L) in all treatments, except for the hottest temperatures, for which we estimated 0.010 mg/L (SD ± 0.017). Applying uctuating temperatures in laboratory bioassays provides a more realistic result for vector surveillance strategies. For a country with continental proportions such as Brazil, considering regionalities is crucial for a rational use of insecticides.

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Regionality in vector control: effect of fluctuating temperature in the susceptibility of Aedes aegypti (Diptera: Culicidae) larvae to Pyriproxyfen

Moura

Corbi

2023

Preprint

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Using Pyriproxyfen to control Aedes aegypti populations shows great potential considering its high competence in low dosages and environmental safety. As an endocrine disruptor, temperature can interfere in its efficiency, related to a decrease in larval emergence inhibition in hotter environments. However, previous studies have been performed at constant temperatures in the laboratory, which may not precisely reflect the environmental conditions in the field. This study aimed to assess the effect of the fluctuating temperatures in pyriproxyfen efficiency on controlling Aedes aegypti larvae. We selected maximum and minimum temperatures from the Brazilian Meteorological Institute database from September to April for cities grouped by five regions. Five fluctuating temperatures (17–26; 20–28.5; 23–32.5; 23–30.5; 19.5–31 ºC) were applied to bioassays assessing Pyriproxyfen efficiency in preventing adult emergence in Aedes aegypti larvae in five concentrations. The proportion of emergence inhibition was compared among treatments and within treatment. In thermal conditions with the lowest temperatures, Pyriproxyfen was efficient to prevent the emergence of twice the larvae than in the hottest temperatures with the lowest concentration applied (average ± SD: 0.61 ± 0.09 in coldest treatment; average ± SD: 0.65 ± 0.12 in the hottest treatment, p value = 0.00015). The concentration that inhibits the emergence of 50% of the population was lower than that preconized by the World Health Organization (0.01 mg/L) in all treatments, except for the hottest temperatures, for which we estimated 0.010 mg/L (SD ± 0.017). Applying fluctuating temperatures in laboratory bioassays provides a more realistic result for vector surveillance strategies. For a country with continental proportions such as Brazil, considering regionalities is crucial for a rational use of insecticides.

show abstract

The impact of insect growth regulators on adult emergence inhibition and the fitness of Aedes aegypti field populations in Thailand

Cited by 4 publications

References 40 publications

The impact of non-lethal doses of pyriproxyfen on male and female Aedes albopictus reproductive fitness

The impact of non-lethal doses of pyriproxyfen on male and female Aedes albopictus reproductive fitness

Regionality in vector control: effect of fluctuating temperature in the susceptibility of Aedes aegypti (Diptera: Culicidae) larvae to Pyriproxyfen

Regionality in vector control: effect of fluctuating temperature in the susceptibility of Aedes aegypti (Diptera: Culicidae) larvae to Pyriproxyfen

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