The impact of indirect (herd) protection on the cost-effectiveness of pneumococcal conjugate vaccine

Isaacman, Daniel J.; Strutton, David; Kalpas, E; Horowicz-Mehler, N.; Stern, Lee; Casciano, Roman; Ciuryla, Vincent

doi:10.1016/j.clinthera.2008.02.003

Cited by 39 publications

(37 citation statements)

References 43 publications

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“…A large proportion of PCV7 benefits has been attributed to herd protection 48. Incorporating herd protection has a huge impact on the cost-effectiveness analysis of PCV, resulting in much more favourable ICERs 49. On the other hand, other pneumococcal serotypes may emerge as significant pathogens (serotype replacement) reducing the overall direct effects of vaccination 48.…”

Section: Discussionmentioning

confidence: 99%

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

Sartori¹,

Novaes

2010

J Epidemiol Community Health

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Section: Discussionmentioning

confidence: 99%

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

Sartori¹,

Novaes

2010

J Epidemiol Community Health

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“…Another study estimated inpatient pediatric and adult costs per case of IPD combined with the pediatric and adult outpatient costs to be a total direct cost of RM 3,737,584 for meningitis alone, although whether per hospital or spread across the four centers is not clear [48]. In addition this did not account for the indirect costs, which have been shown to be considerable [49]. Quadrivalent immunization against meningococcal serogroups A, C, W, Y is compulsory for pilgrims attending the Hajj [50], although breakthrough infection or a poor individual response to immunization may occur [23].…”

Section: Discussionmentioning

confidence: 96%

Vaccine preventable meningitis in Malaysia: epidemiology and management

McNeil

Jefferies

Clarke

2015

Expert Review of Anti-infective Therapy

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Worldwide bacterial meningitis accounts for more than one million cases and 135,000 deaths annually. Profound, lasting neurological complications occur in 9-25% of cases. This review confirms the greatest risk from bacterial meningitis is in early life in Malaysia. Much of the disease burden can be avoided by immunization, particularly against Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae. Despite inclusion of the Hib vaccine in the National Immunisation Programme and the licensure of pneumococcal vaccines, these two species are the main contributors to bacterial meningitis in Malaysia, with Neisseria meningitidis and Mycobacterium tuberculosis, causing a smaller proportion of disease. The high Hib prevalence may partly be due to dated, small-scale studies limiting the understanding of the current epidemiological situation. This highlights the need for larger, better quality surveillance from Malaysia to evaluate the success of Hib immunization and to help guide immunization policy for vaccines against S. pneumoniae and N. meningitidis.

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“…Indirect protection has been demonstrated to impact the results of HEE of pneumococcal conjugate vaccines. 42 Eight (40%) of the reviewed Brazilian studies took the indirect effects of vaccination into account in the analysis. 19,[21][22][23][26][27][28]32 Among the Spanish HEEs on vaccines, 82% studies did not consider herd protection.…”

Section: Discussionmentioning

confidence: 99%

“…Indirect effects may have a significant impact on the results of HEE of vaccines, mostly but not always, improving the cost-effectiveness of a vaccination program. 41,42 Dynamic transmission models can more easily capture indirect effects of a vaccination program, allowing better representation of reality. Indirect protection has been demonstrated to impact the results of HEE of pneumococcal conjugate vaccines.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of health economic evaluations of vaccines in Brazil

Sartori

Rozman

Decimoni

et al. 2017

Human Vaccines & Immunotherapeutics

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Methods: Systematic review of the literature. We searched multiple databases. Two researchers independently selected the studies and extracted the data. The methodological quality of individual studies was evaluated using CHEERS items. Results: Twenty studies were reviewed. The most evaluated vaccines were pneumococcal (25%) and HPV (15%). The most used types of HEE were cost-effectiveness analysis (45%) and cost-utility analysis (20%). The research question and compared strategies were stated in all 20 studies and the target population was clear in 95%. Nevertheless, many studies did not inform the perspective of analysis or data sources. Conclusions: HEE of vaccines in Brazil has increased since 2008. However, the studies still have methodological deficiencies.

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The impact of indirect (herd) protection on the cost-effectiveness of pneumococcal conjugate vaccine

Cited by 39 publications

References 43 publications

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

Cost-effectiveness of introducing the 10-valent pneumococcal conjugate vaccine into the universal immunisation of infants in Brazil

Vaccine preventable meningitis in Malaysia: epidemiology and management

A systematic review of health economic evaluations of vaccines in Brazil

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