The impact of in-situ balloon occlusion of the renal artery and hypothermic perfusion on renal blood flow

Abstract

Unilateral renal blood flow was evaluated in-situ in 13 dogs by cineangiodensitometry and microsphere distribution studies before and after intermittent balloon occlusion with and without hypothermic perfusion of one kidney. The contralateral kidney served as control. No significant difference in renal blood flow and vascular resistance was noted before, and 5, 30 and 60 minutes after unilateral intra-arterial manipulation. Compartmental flow distribution studies in 5 dogs revealed no evidence of alteration of intra-renal haemodynamics. In a clinical pilot study, unilateral renal blood flow measured by cineangiodensitometry showed no change of clinical significance 5 and 60 minutes after intraluminal balloon occlusion of the renal artery for 60 seconds.

Renal Blood Flow Alterations after Temporary Ischemia

“…Other au thors have reported a similar observation [13,24], whereas others found no significant response [25] or even a decrease of renal blood flow parameters. The renal response by temporary ischemia is, however, extremely dependent on species [12,26], and on the method for blood flow measurements [19] and most studies cannot be compared with each other.…”

Inosine: Alternative or Adjunct to Regional Hypothermia in the Prevention of Post-Ischemic Renal Failure?

“…In the kidneys subjected to 2 h of warm ischemia, there was no statistical dif ference between the functional loss of the inosineprotected kidneys and the unprotected control kid neys. In the majority of kidneys subjected to 90 min of warm ischemia (+ 90 min of cold ischemia), inosine prevented the severe renal da a fact known for over occlusion of the renal artery and hypothermic per fusion per se does not cause significant hemo dynamic alterations in the postischemic phase (15).…”