Renal Blood Flow Alterations after Temporary Ischemia

Pflüger, Heinz; Maier, Martin; Wagner, Michael; Binder, Bernd R.; Marberger, Michael

doi:10.1159/000474060

Cited by 7 publications

(7 citation statements)

References 25 publications

(31 reference statements)

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“…As repeatedly reported in the literature [15,16], expo sure of the kidneys to 60 min of normothermic ischemia was also found in our experiments to increase the organ weight by 24%. While there was also a significant weight gain when antiproteases were administered, it was signif icantly less pronounced than in the untreated ischemic kidneys (p < 0.05).…”

Section: Discussionsupporting

confidence: 91%

“…By contrast, the comparison of left ischemic kidneys of groups A, E and G with their right counterparts showed a highly significant rise in blood flow at 10 min in group A, as published elsewhere. At 30 min no difference in renal cortical blood flow between the left and right sides was seen [16]. Ani mals of group E (aprotinin-treated) had significantly ele vated blood flow values in their ischemic kidney versus the contralateral controls at 10 and 30 min of reperfusion (p < 0.05), (fig.…”

Section: Resultsmentioning

confidence: 89%

“…The significant hyperemia in the renal cortex seen after 60 min of normothermic ischemia in rabbits [16] might suggest a causal involvement of kallikrein and prostaglandins [19], as has been proposed for hypoxia of short duration [12,13]. The direct action of kallikrein on the smooth muscle cells as well as its secondary effect in terms of prostaglandin release, could dilate the blood ves sels, increase the blood flow and, at the same lime, reduce vascular resistance.…”

Section: Discussionmentioning

confidence: 84%

“…Minn.). A detailed description of the experimental design was published elsewhere [16], Renal vascu lar resistance was calculated as the ratio between mean arterial blood pressure at the time of microsphere injection and renal cortical blood flow, MAP/RCBF. Renal cortical blood flow was expressed in ml/min both for 1 g of wet weight and, after freeze-drying the speci mens, for 1 g of dry weight.…”

Section: Methodsmentioning

confidence: 99%

“…While the vascular response to normothermic ischemia of the kidney was found to be species-dependent in animal experiments, studies in dogs [12] and cats [13] consistently showed short-term inter ruption (1-3 min) of renal arterial circulation to be fol lowed by reactive hyperemia, which predominantly af fects the deep layers of the renal cortex [14]. Analogous changes in renal blood flow were seen after 60 min of normothermic ischemia [15,16].…”

mentioning

confidence: 99%

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Effects of Antiproteases (Aprotinin and Gabexate-Mesilate) on the Postischemic Vascular Response of the Kidney

1983

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Both under physiologic conditions and after short-term ischemia (1–3 min) kallikrein and locally synthesized prostaglandins contribute to control renal blood flow. In the present experiment the antiproteases aprotinin and gabexate-mesilate were administered to rabbits in an attempt to show whether the hemodynamic changes produced by 60 min of normothermic ischemia, i.e., postischemic hyperemia and reduction of vascular resistance, were equally mediated by kallikrein. Vascular responses were evaluated by determining renal cortical blood flow using radioactively labelled microspheres, by calculating vascular resistances, and by measuring the diameters of renal medullary vessels. Kidneys exposed to normothermic ischemia and sham-operated control organs of animals treated with aprotinin (2 × 40,000 KlU/kg body weight) and gabexate-mesilate (2X7 mg/kg body weight) were compared with those of rabbits which were analogously operated, but did not receive any drugs. As the antiproteases used did not significantly affect the hyperemia and the reduction of renal cortical vascular resistance seen after 60 min of normothermic ischemia, these phenomena are apparently not mediated by kallikrein. Renal medullary vasodilatation (arteriolae rectae) was significantly lower under aprotinin than in untreated ischemic kidneys, and was not longer demonstrable in gabexate-mesilate-treated animals. Thus, the effect of gabexate-mesilate was superior to that of aprotinin. Whether the antiprotease action is due to an unspecific membrane-stabilizing, to a general ezyme-inhibiting, or to a specific kallikrein-inhibiting effect, is still unclear.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Effects of Antiproteases (Aprotinin and Gabexate-Mesilate) on the Postischemic Vascular Response of the Kidney

1983

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Cortical blood-flow in the porcine kidney

Poulsen

Jørgensen

Madsen³

et al. 1988

Urol. Res.

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Renal cortical blood-flow distribution was measured by means of radiolabeled microscopheres in eight kidneys from 4 pigs of mixed Yorkshire and Danisk landrace. We found a pronounced intracortical variation in the perfusion pattern of 28 sections of outer cortex. Three consequetive flow determinations with an interval of 45 minutes showed that the heterologous perfusion pattern was plastic, changing between the flow-determinations. In addition, we found a significantly reduced perfusion in the renal poles, compared to the rest of the outer cortex. It is speculated that the reduced polar perfusion is a contributing aetiological factor to the increased incidence of polar scar formation secondary to reflux nephropathy.

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Effects of External Renal Hypothermia on Postischemic Hemodynamics

Zechner¹,

Pflüger²,

Maier³

et al. 1983

Urol Int

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In the rabbit model renal cortical blood flow after 60 min of normothermic ischemia is seen to rise significantly in the early reperfusion period. Under otherwise identical conditions this phenomenon is absent after hypothermic ischemia produced by surface cooling of the kidney and in sham-operated kidneys. It is still unclear whether postischemic hyperemia is a physiologic counterregulatory mechanism in response to 60-min normothermic ischemia of the rabbit kidney or a contributory factor in the development of acute postischemic renal failure.

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Renal Blood Flow Alterations after Temporary Ischemia

Cited by 7 publications

References 25 publications

Effects of Antiproteases (Aprotinin and Gabexate-Mesilate) on the Postischemic Vascular Response of the Kidney

Effects of Antiproteases (Aprotinin and Gabexate-Mesilate) on the Postischemic Vascular Response of the Kidney

Cortical blood-flow in the porcine kidney

Effects of External Renal Hypothermia on Postischemic Hemodynamics

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