The Impact of<i>CDH13</i>Polymorphism and Statin Administration on TG/HDL Ratio in Cardiovascular Patients

Choi, Jung Ran; Jang, Yangsoo; Yoon, Sungjoo Kim; Park, Jong Keun; Sorn, Sungbin Richard; Park, Mi Young; Lee, Myoungsook

doi:10.3349/ymj.2015.56.6.1604

Cited by 10 publications

(13 citation statements)

References 32 publications

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“…Internal quality control measures were to ensure data fidelity, that is, a QC call rate (Dynamic Model algorithm) always was over 86% and correct identification of subject gender based on heterozygosity on the X chromosome. Genotype calling was performed using the Birdseed v2 algorithm [25].…”

Section: Methodsmentioning

confidence: 99%

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Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene

Lee

et al. 2019

JCM

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Elevated serum urate (sUA) concentrations have been associated with an increased risk of hypertension. We aimed to examine the association of sUA concentration on the risk of hypertension in pre- and post-menopausal women and investigated the association between the polymorphism of the xanthine dehydrogenase gene and the risk of hypertension. Among 7294 women, 1415 premenopausal and 5879 postmenopausal women were recruited. Anthropometric parameters as risk factors of hypertension were identify by logistic regression models. In addition, we investigated an association between xanthine dehydrogenase gene and sUA and their combined associations on the risk of hypertension. Body mass index (BMI) and waist circumference (WC) were significantly increased in accordance to the increase of sUA levels (p < 0.001). Multivariate logistic regression analysis showed postmenopausal women with a high sUA and high BMI were 3.18 times more likely to have hypertension than in those with normal and lower sUA (Odds ratio: 3.18, 95% confidence interval: 2.54–3.96). Postmenopausal women with a high WC were 1.62 times more likely to have hypertension than in those with normal and lower sUA. Subjects with the AG genotype of rs206860 was found to be at lower risk of hypertension (odd ratio: 0.287, 95% confidence interval: 0.091–0.905, p = 0.033). This cross-sectional study indicated a high sUA is associated with a higher risk of hypertension in postmenopausal women. Further well-designed prospective studies in other populations are warranted to validate our results.

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Section: Methodsmentioning

confidence: 99%

“…Genomic DNA was extracted from 5 mL of peripheral venous blood using a commercially available isolation kit (QuickGene SP Kit DNA whole blood, Fujifilm, Tokyo, Japan). Genotyping was performed using the TaqMan fluorogenic 5’ nuclease assay (Applied Biosystems) [25].…”

Section: Methodsmentioning

confidence: 99%

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene

Lee

et al. 2019

JCM

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“…de Keyser et al (2015) [38] Prospective The minor G allele of the rs13064411 polymorphism was associated with a decreased LDL-lowering response to statins. Choi et al (2015) [39] Prospective Plasma adiponectin levels and TG/HDL ratio were significantly different according to variants of CDH13 and statin administration. Leusink et al (2014) [40] Case-control We found no association of the CYP3A4*22 minor allele (rs35599367) with the effectiveness of statins in reducing MI risk.…”

Section: Article Title Study Design Conclusionmentioning

confidence: 97%

“…The literature search was limited by available databases and access. The number of publications in this topic is relatively [9,[13][14][15] X X SLCO1B1 [16,17] X X APOE [9,10,14,18,19] X X PON1 [23,24] X X RYR2 [27] X X RYR2 [17] X X TLR4, [10] LTa C804A, [31] LPA, [9] NPC1L1, [18] HLA-G, [32] CYP3A4*2, [33] eNOS, [33] CYP2D6, [34] ABCB1, [35] CETP, [14] SREBF1,2, [36] KIF16, [37] HMGCR, [14,19] SORT1/CELSR2/PSRC1 [19,24] X X ACE, [10] HL, [10] WDR52, [38] CDH13, [39] CYP3A4*2 [40] X X HLA-DRB1, [17] LILRB5 [25] X X COQ2, [15] GATM [17,30] X X Pharmacogentics of statins Anas S. Aldawsari and Mohammad S. Shawaqfeh scares which made the literature search a real challenge. There were limited numbers of randomised controlled studies and meta-analysis in the topic.…”

Section: Limitationsmentioning

confidence: 99%

Clinical evidence of pharmacogenetics of statins: systematic literature review

Aldawsari

Shawaqfeh

2019

J Pharm Health Serv Res

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Objectives A systematic review was conducted to explore the clinical evidence of pharmacogenetic testing with statins in a personalised approach to minimise the incidence of adverse drug reaction (ADR), ensure better response and optimise medication adherence. Methods Systematic literature review using PubMed and EMBASE/Medline database that includes all clinically relevant pharmacogenomic studies involving statins. Key findings Twenty-four articles were evaluated for a total of 120 articles screened. The included studies were classified according to study design (two randomised controlled trial studies (RCTs), three meta-analysis studies, two interventional studies, four prospective studies, 10 case-control studies, two cross-sectional studies and one data analysis study). There were 23 different genetic polymorphisms related to statins were studied clinically with the specified outcome either LDL-lowering response or adverse drug reaction. Those genes were diverse and involve metabolic enzymes, transporters and other receptors. Conclusions Many studies suggest a strong association between clinical outcomes and certain genes relevant to statins. However, these studies were observational and only a few were randomised controlled trials (RCTs). The strength of evidence to support pharmacogenetic testing for statin is not adequate.

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“…Genomic DNA was drawn from 5 mL of peripheral venous blood using an isolation kit (QuickGene SP Kit DNA whole blood, Fujifilm, Tokyo, Japan). Genotyping was performed using the TaqMan fluorogenic 5′ nuclease assay (ABI) [27].…”

Section: Sequencing and Genotypementioning

confidence: 99%

Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

2020

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Background: Hypertension is one of the risk factors for obesity-related cardiovascular diseases. We investigated whether genetic variations in serotonin 2A receptor (HTR2A) were associated with hypertension. Methods: We carried out a cross-sectional study in cohorts A (Ansan-Ansung cohort, N = 6039) and B (Wonju-Pyengchang cohort, N = 7524). Several genetic variants in HTR2A including rs7330636, rs9590999, rs2183057, and rs4942595 were selected and genotyped. Results: In hypertensive participants in cohort A, the baseline systolic blood pressure and body mass index were 141.80 ± 17.20 mg/dL and 24.48 ± 4.75 kg/m 2 , respectively, which were higher than in those without hypertension (p < 0.001). rs4942595TC genotype was associated with hypertension in cohort A (OR = 0.739), after adjusting for variables. Subjects with rs4942578AA genotype had a decreased risk of hypertension after adjusting for clinical factor (OR = 0.735) in cohort B, and an elevated risk of hypertension in cohort A (OR = 1.562). The logistic regression analysis showed that participants with rs4941573TC genotype were 1.327 times more likely to have a higher blood pressure than those with TT genotype (95% CI 1.101-1.599) in cohort B. Whereas, the OR for developing hypertension in subjects with rs17069883CC genotype compared to those with AA genotype was 1.447 (95% CI 1.018-2.056; p for trend = 0.040) in cohort A. Conclusions: HTR2A genetic variations were associated with hypertension risk in our study.

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The Impact ofCDH13Polymorphism and Statin Administration on TG/HDL Ratio in Cardiovascular Patients

Cited by 10 publications

References 32 publications

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene

Association between Serum Urate and Risk of Hypertension in Menopausal Women with XDH Gene

Clinical evidence of pharmacogenetics of statins: systematic literature review

Association between serotonin 2A receptor (HTR2A) genetic variations and risk of hypertension in a community-based cohort study

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