The impact of hs C-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes

Zairis, Michael N.; Adamopoulou, Evdokia N.; Manousakis, Stavros J.; Lyras, Anastassios G.; Bibis, George P.; Ampartzidou, Olga S.; Apostolatos, Charalambos S.; Anastassiadis, Filippos A.; Hatzisavvas, John J.; Argyrakis, Spyros K.; Foussas, Stefanos

doi:10.1016/j.atherosclerosis.2006.08.008

Cited by 52 publications

(32 citation statements)

References 24 publications

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“…Systemic levels of inflammatory markers are associated with elevated cardiovascular risk in adult populations. This association has been reported for peripheral blood leukocyte counts, CRP and interleukin-6 [39]. In general, this relationship has been attributed to inflammation and atherosclerosis occurring in the arterial wall [15].…”

Section: Correlation Of Pre-op Levels Of Leukocyte or D-dimer With Cosupporting

confidence: 57%

“…Various types of inflammatory cells, including monocytes, lymphocytes, eosinophils, and neutrophils, have been implicated in CHD [28]. Numerous epidemiologic and clinical studies have shown the leukocyte count to be an independent risk factor for CHD, a risk factor for future cardiovascular events in individuals apparently without cardiovascular disease (CVD), and a prognostic marker of future events in patients who already have CVD [39].…”

Section: Correlation Of Pre-op Levels Of Leukocyte or D-dimer With Comentioning

confidence: 99%

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Clinical Usefulness of Preoperative Levels of Leukocyte and D-Dimer in Predicting Perioperative Outcomes of Cardiovascular Disease

Choi¹,

Kim²,

Hwang³

2010

Journal of Life Science

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The present study was retrospectively designed to define whether preoperative levels of leukocytes and D-dimer are potentially useful factors in predicting perioperative outcomes of coronary heart disease (CHD). There was no relationship between preoperative leukocyte counts (Pre-OP leukocyte) and preoperative D-dimer levels (Pre-OP D-dimer). Pre-OP leukocyte counts each had positive correlation with cardiac troponin-I, creatine kinase-MB or C-reactive protein (cardiac markers) levels at preoperative and postoperative periods. Pre-OP D-dimer levels were positively associated with each cardiac marker at the same periods. Pre-OP leukocyte counts positively related with aspartate aminotransferase and alanine aminotransferase (liver markers), whereas Pre-OP D-dimer level positively or negatively correlated with bilirubin (liver marker), creatinine (renal marker) or glucose levels at preoperative and/or postoperative periods. Pre-OP leukocyte and Pre-OP D-dimer were inversely associated with Pre-OP high density lipoprotein cholesterol levels or left ventricular ejection fraction. Pre-OP leukocyte counts each had positive correlation operation duration and postoperative mechanical ventilation-time (PMVT), whereas Pre-OP D-dimer levels had positive relationship with PMVT, intensive care unit-staying period and hospitalization. The retrospective data suggest that Pre-OP leukocyte and Pre-OP D-dimer levels may be clinically useful factors for predicting perioperative outcomes in patients with CHD.

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Section: Correlation Of Pre-op Levels Of Leukocyte or D-dimer With Cosupporting

confidence: 57%

Section: Correlation Of Pre-op Levels Of Leukocyte or D-dimer With Comentioning

confidence: 99%

Clinical Usefulness of Preoperative Levels of Leukocyte and D-Dimer in Predicting Perioperative Outcomes of Cardiovascular Disease

Choi¹,

Kim²,

Hwang³

2010

Journal of Life Science

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“…Cardiol. 33, 4, 206 -212 (2010) with ACS have been directly associated with mortality at 14 days, 14 30 days, 15 and 5 years, 17 and with cardiovascular events and mortality at 6 months. 16 Whether interventions that lower CRP levels can have an independent effect on clinical outcomes is not known.…”

Section: Discussionmentioning

confidence: 99%

Changes in Inflammatory Biomarkers in Patients Treated With Ticagrelor or Clopidogrel

Husted

Storey

Harrington

et al. 2010

Clinical Cardiology

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Background: Inflammation is a key factor in the development of atherosclerotic disease and acute coronary syndromes (ACS). The P2Y 12 receptor antagonists ticagrelor (AZD6140) and clopidogrel may have antiinflammatory effects. The objective of this analysis from the Dose Confirmation Study Assessing Anti-Platelet Effects of AZD6140 vs Clopidogrel in NSTEMI 2 (DISPERSE 2) trial was to compare ticagrelor and clopidogrel for effects on the inflammatory biomarkers C-reactive protein (CRP), interleukin 6 (IL-6), myeloperoxidase (MPO), and soluble CD40 ligand (sCD40L). Hypothesis: Ticagrelor inhibits the P2Y 12 receptor and inflammation to a greater extent than clopidogrel in nonST-segment elevation ACS (NSTE-ACS) patients. Methods: In a double-blind, double-dummy, multicenter trial, 990 patients who had been hospitalized within the previous 48 hours with NSTE-ACS were randomized to receive ticagrelor 90 mg twice daily, ticagrelor 180 mg twice daily, or clopidogrel 300 mg initially and then 75 mg once daily. Within the ticagrelor groups, patients were also randomized to receive or not receive a loading dose of ticagrelor 270 mg initially. All patients received standard treatment for ACS, which included 325 mg aspirin initially and 75 to 100 mg aspirin each day subsequently. Inflammatory biomarkers were measured at baseline, upon hospital discharge, and after 4 weeks. Results: Inflammatory biomarker measurements were not significantly different among treatment groups at baseline, discharge, and 4 weeks. Conclusions: Ticagrelor and clopidogrel appeared not to differ in this study with respect to the inflammatory biomarkers CRP, IL-6, MPO, and sCD40L in patients with NSTE-ACS.

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“…The inflammatory markers which predict CAD events include C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), fibrinogen and tumor necrosis factor-± (TNF-±). 11,12 The markers of atherosclerosis include ankle arm index (AAI) and aortic pulse wave velocity (aPWV), a marker of arterial stiffness. Combination of measures of inflammation and atherosclerosis might be useful for identification of very high risk in adults.…”

mentioning

confidence: 99%

Assesment of Coronary Artery Disease by The Detection of Inflammatory Marker Like Erythrocyte Sedimentation Rate, Neutrophil Lymphocyte Ratio and Leucocyte Count

et al. 2015

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Background: The inflammatory marker like erythrocyte sedimentation rate (ESR), neutrophil lymphocyte ratio (NLR), total leucocyte count can be a useful tool to detect and measure the early detection of coronary artery disease (CAD). Objective: To assess the ESR, NLR and total leucocyte count as a useful inflammatory marker for detection of coronary artery disease (CAD). Methods: This case control study was conducted in the Department of Clinical pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for further percutaneous coronary intervention (PCI) in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (Patients with CAD) and 50 controls were Group II (Patients without CAD). Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by percutaneous coronary intervention (PCI) were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis who were diagnosed by percutaneous coronary intervention (PCI) were included in this study as control. The statistical analysis was done by Chi-square test and unpaired samplet test. Results: NLR and ESR was higher in CAD (+) group compared to group without CAD (-) (2.76 (±0.74) vs. 1.56 (±0.15), p<0.001) and (31.07± (18.25) vs. 11.76± (6.20), p<0.001).Conclusion: ESR and NLR was higher in patients with angiographically proven CAD compared to those without CAD. ESR and NLR may be a useful inflammatory marker to detect the presence of CAD.University Heart Journal Vol. 10, No. 2, July 2014; 55-59

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The impact of hs C-reactive protein and other inflammatory biomarkers on long-term cardiovascular mortality in patients with acute coronary syndromes

Cited by 52 publications

References 24 publications

Clinical Usefulness of Preoperative Levels of Leukocyte and D-Dimer in Predicting Perioperative Outcomes of Cardiovascular Disease

Clinical Usefulness of Preoperative Levels of Leukocyte and D-Dimer in Predicting Perioperative Outcomes of Cardiovascular Disease

Changes in Inflammatory Biomarkers in Patients Treated With Ticagrelor or Clopidogrel

Assesment of Coronary Artery Disease by The Detection of Inflammatory Marker Like Erythrocyte Sedimentation Rate, Neutrophil Lymphocyte Ratio and Leucocyte Count

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