The impact of high progesterone levels on the day of HCG administration in assisted
            human reproduction treatments

Tanada, Michelli Suemi; Yoshida, Ivan Henrique; Santos, Monise; Berton, Caroline Z; Souto, Elen; Carvalho, Waldemar Pereira de; Cordts, Emerson Barchi; Barbosa, Caio Parente

doi:10.5935/1518-0557.20180020

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…18 On the contrary, several studies suggested that the serum P level elevation on the trigger day showed no effect on clinical outcomes. [19][20][21] To determine whether there is such phenomenon in the IVF cycles of our reproductive medicine centre, we first grouped all data according to different P levels on the hCG trigger day (cut-off value: 1.5 ng/mL). Our study, including 1664 IVF-ET cycles, showed that when the serum P level was greater than 1.5 ng/mL, the CPR of all patients was not significantly decreased.…”

Section: Discussionmentioning

confidence: 99%

Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles

Jiang,

Kong,

Shi

et al. 2023

IJWH

View full text Add to dashboard Cite

Background Previous studies suggested higher serum progesterone (P) levels were strongly associated with a lower clinical pregnancy rate (CPR) for in vitro fertilization-embryo transfer (IVF-ET). However, the effect of increased serum P levels on the day of human chorionic gonadotropin (hCG) administration on clinical outcomes in short-acting gonadotropin-releasing hormone agonist (GnRHa) downregulated IVF-ET cycles remains unclear. Methods We conducted a retrospective cohort study from January 2017 to December 2021, which included a total of 1664 patients receiving their first short-acting GnRHa IVF-ET cycles at our reproductive medicine centre of Nanjing Drum Tower Hospital. The smooth curve fitting and interaction analysis were employed to analyse the association between the CPR and the serum P levels with different embryo types (cleavage-stage embryo or blastocyst). In addition, total cycles were grouped according to different P levels on the trigger day of hCG administration for further analysis. Results The CPR of patients with increased serum P level (higher than 1.5 ng/mL) on the hCG day did not decrease. A smoothing curve fitting showed that the CPR did not change obviously with the increase in serum P levels. Subgroup analysis of different types of embryos transferred showed that no correlation was observed between the CPR and serum P levels on the day of hCG administration in cleavage-stage embryo transfer cycles. However, the CPR of patients receiving blastocyst transfer showed a downward trend with the increase in serum P levels. At the same time, an interaction analysis also confirmed that the CPR of blastocyst transfer was more likely to be affected by elevated serum P levels on the hCG day. Conclusion In the luteal phase short-acting GnRHa downregulated IVF-ET cycles, the elevated serum P levels on the hCG day did not affect the CPR of cleavage-stage embryo transfer but reduced the CPR of blastocyst transfer.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles

Jiang,

Kong,

Shi

et al. 2023

IJWH

View full text Add to dashboard Cite

show abstract

Prediction of ovarian response in IVF/ICSI cycles

Cortés-Vazquez¹,

Goitia-Landeros²,

Regalado³

et al. 2021

JBRA

View full text Add to dashboard Cite

Objective: Our study aims to evaluate the various correlations between demographic, biochemical, ultrasound, and ovarian stimulation parameters with the percentage of mature oocytes in conventional stimulation for IVF/ICSI cycles in order to develop a predictive model to improve our understanding of the oocyte maturation process.Methods: This is a retrospective cohort study; patients underwent conventional antagonist ovarian stimulation protocols for fresh IVF/ICSI cycles. A total of 256 IVF/ ICSI cycles were included. Age, antral follicle count (AFC), baseline serum follicle-stimulating hormone (FSH) levels, baseline serum luteinizing hormone (LH) levels, baseline serum estradiol (E2) levels, peak estradiol, P4 on hCG day, the body mass index (BMI), and stimulation length were measured. The variables were tested for correlations with the number of retrieved oocytes (#RO) and the number of mature oocytes (#MO). A backward stepwise regression was performed to identify the variables that correlated more strongly with percentage of mature oocytes (%MO).Results: A predictive equation was obtained with the variables that were not excluded in the model. % MO = 72.700 -0.910 (Age) + 0.979 (BMI) + 1.209 (Baseline serum LH) -0.647 (Progesterone on human Chorionic Gonadotropin day).Conclusions: We concluded that age, the BMI, baseline serum LH, and progesterone level on hCG day may predict %MO. Prospective studies are required to validate this predictive equation.

show abstract

The impact of high progesterone levels on the day of HCG administration in assisted human reproduction treatments

Cited by 2 publications

References 8 publications

Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles

Effect of Elevated Progesterone Levels on hCG Trigger Day on Clinical Pregnancy Outcome in Short-Acting GnRHa Downregulated Cycles

Prediction of ovarian response in IVF/ICSI cycles

Contact Info

Product

Resources

About