Abstract:Objective: Our study aims to evaluate the various correlations between demographic, biochemical, ultrasound, and ovarian stimulation parameters with the percentage of mature oocytes in conventional stimulation for IVF/ICSI cycles in order to develop a predictive model to improve our understanding of the oocyte maturation process.Methods: This is a retrospective cohort study; patients underwent conventional antagonist ovarian stimulation protocols for fresh IVF/ICSI cycles. A total of 256 IVF/ ICSI cycles were … Show more
“…Even age does not critically influence oocyte maturation rates based on our findings. These findings partially agree with a prior study at our institution ( Cortés-Vazquez et al ., 2021 ). Additionally, our previous experience could only reflect the patients’ outline corresponding to low ovarian responders.…”
Section: Discussionsupporting
confidence: 94%
“…Oocytes were retrieved transvaginally 34-36 hours after rhCG administration. Oocytes were graded for maturity based on the morphological characteristics as previously described ( Cortés-Vazquez et al ., 2021 ).…”
Section: Methodsmentioning
confidence: 99%
“…Previous experience shows a negative influence of progesterone in oocyte maturation (Cortés-Vazquez et al, 2021;Salehnia & Zavareh, 2013). So it is reasonable to assess the impact of progesterone levels on HCG day on the oocyte maturation process.…”
Objective
Does progesterone levels on hCG day influence maturation rates and number of
mature oocytes during ovarian stimulation for IVF/ICSI cycles?.
Methods
A retrospective, observational, analytic, cross-sectional and cohort study
was performed at the Reproductive Endocrinology Department of the Centro
Médico Nacional 20 de Noviembre in Mexico City between 2015 to 2020.
All female patients underwent an ovarian stimulation cycle for IVF/ICSI,
either with a mild or conventional stimulation protocol. Patients were
classified according to their progesterone levels, Group 1 <1.5ng/ml and
Group 2 >1.5mg/ml. A Spearman Rho test, a simple linear regression model,
a Principal Component Analysis and a Student’s T-test, were performed.
Results
A total of 600 patients were included. The overall results showed that there
is a positive correlation between the number of retrieved, mature oocytes
and progesterone levels on HCG day. After the Principal Component Analysis
we observed that poor ovarian responders had the lowest maturation rate and
number of mature oocytes. While the Student’s t test showed that
progesterone levels beyond 1.5ng/ml are associated to a higher number of
mature oocytes but not a better maturation rate.
Conclusions
Higher serum progesterone levels are associated with increased retrieved and
mature oocytes in high responders. At the same time, higher progesterone
levels in lower responders are not associated with optimal ovarian
response.
“…Even age does not critically influence oocyte maturation rates based on our findings. These findings partially agree with a prior study at our institution ( Cortés-Vazquez et al ., 2021 ). Additionally, our previous experience could only reflect the patients’ outline corresponding to low ovarian responders.…”
Section: Discussionsupporting
confidence: 94%
“…Oocytes were retrieved transvaginally 34-36 hours after rhCG administration. Oocytes were graded for maturity based on the morphological characteristics as previously described ( Cortés-Vazquez et al ., 2021 ).…”
Section: Methodsmentioning
confidence: 99%
“…Previous experience shows a negative influence of progesterone in oocyte maturation (Cortés-Vazquez et al, 2021;Salehnia & Zavareh, 2013). So it is reasonable to assess the impact of progesterone levels on HCG day on the oocyte maturation process.…”
Objective
Does progesterone levels on hCG day influence maturation rates and number of
mature oocytes during ovarian stimulation for IVF/ICSI cycles?.
Methods
A retrospective, observational, analytic, cross-sectional and cohort study
was performed at the Reproductive Endocrinology Department of the Centro
Médico Nacional 20 de Noviembre in Mexico City between 2015 to 2020.
All female patients underwent an ovarian stimulation cycle for IVF/ICSI,
either with a mild or conventional stimulation protocol. Patients were
classified according to their progesterone levels, Group 1 <1.5ng/ml and
Group 2 >1.5mg/ml. A Spearman Rho test, a simple linear regression model,
a Principal Component Analysis and a Student’s T-test, were performed.
Results
A total of 600 patients were included. The overall results showed that there
is a positive correlation between the number of retrieved, mature oocytes
and progesterone levels on HCG day. After the Principal Component Analysis
we observed that poor ovarian responders had the lowest maturation rate and
number of mature oocytes. While the Student’s t test showed that
progesterone levels beyond 1.5ng/ml are associated to a higher number of
mature oocytes but not a better maturation rate.
Conclusions
Higher serum progesterone levels are associated with increased retrieved and
mature oocytes in high responders. At the same time, higher progesterone
levels in lower responders are not associated with optimal ovarian
response.
“…The application of short focused U/S protocols helps to diagnose diseases of lower extremities, aorta, pulmonary arteries, atherosclerotic changes in vessels (Balakhonova et al, 2022). The development of supplementary reproductive technologies made U/S a key method in the evaluation of ovarian syndrome, as well as the control method in ovary paracentesis with ovum collection for IFV and monitoring of the patient's condition after the embryo transfer into the uterine cavity (Cortés-Vazquez et al, 2021). The absence of radiation exposure resulted in the fact that U/S method is the most sought-after for (Lees et al, 2022).…”
Relevance. For more than 100 years, medical practice has used imaging methods to observe pathological changes localized in the human body. The first method was radiography, which became popular among doctors, but later it turned out that high radiation exposure increases the incidence of tumor diseases, which is why standards for permissible radiation doses were developed for patients and radiologists. The introduction of radiocontrast agents also had contraindications that should be taken into account. Ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and angiography methods have significantly increased the diagnostic capabilities of instrumental methods. The purpose of this review is to analyze the advantages and disadvantages of modern imaging methods in medicine. Methods. To achieve the purpose of the review, a literature search was conducted in Google Scholar and PubMed databases. Results. 1) The main indication for the X-ray method is visualization of bone structures. 2) X-ray contrast methods are optimal for studying hollow organs and blood vessels. 3) The advantage of MRI is the ability to visualize soft tissue well. 4) CT helps to reconstruct the spatial architecture of organs. 5) Ultrasound allows you to observe the condition of the embryo and fetus, as well as internal organs.
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