The Impact of “High-Producer” Interleukin-6 Haplotypes on Cardiovascular Morbidity and Mortality in a Kidney Transplant Population

Krüger, Bernd; Walberer, Andreas; Farkas, S.; Tokmak, Faruk; Obed, Aiman; Schenker, Peter; Henning, B. F.; Schlitt, HJ; Krämer, Bernhard K.; Banas, Bernhard

doi:10.1016/j.transproceed.2009.06.123

Cited by 6 publications

(2 citation statements)

References 31 publications

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“…A smaller study with 157 patients demonstrated, in a subgroup with prevalent acute rejection episode, a significantly worse graft survival in patients with acute rejection bearing the TNF-α high producer genotype [27]. Similar results were found for IL-6; in a study of 352 patients, no effect of the –174G allele, or of the whole gene diversity, distinct by the polymorphisms –174G/C and 1888G/T, could be found, an effect which was also reported by another group analyzing 224 renal transplant recipients [14,15]. …”

Section: Long-term Allograft Dysfunction and Mortalitysupporting

confidence: 68%

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Genetic Variations and Transplant Outcomes

Krüger

Schröppel²

2010

Nephron Clin Pract

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Extensive genetic variation has been described in molecules regulating innate and adaptive immunity, pharmacokinetics, coagulation, and fibrosis. However, large prospective studies need to be performed to define the clinical consequences of such variation and the potential benefits of genotyping these markers for patients. The purpose of this review is to summarize recent data describing associations of polymorphisms in both immunological and non-immunological molecules with transplant outcomes, and discuss their clinical implications and limitations.

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Section: Long-term Allograft Dysfunction and Mortalitysupporting

confidence: 68%

“…Most studies have examined the promoter polymorphism –174G/C (rs1800795), which represents in combination with an additional SNP (rs1800795) the whole IL-6 gene diversity. Despite postulated functional effects of the IL-6 SNP, no impact on acute rejection was found in different studies [14,15]. …”

Section: Acute Rejectionmentioning

confidence: 99%