2012
DOI: 10.1016/j.trim.2011.10.003
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Association between IL-6 –174G/C polymorphism and acute rejection of renal allograft: Evidence from a meta-analysis

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Cited by 21 publications
(18 citation statements)
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“…Many studies have investigated the association between cytokine gene polymorphisms and acute renal graft rejection, with different studies reporting different results. [1,3,5,17–25] The variable clinical diagnostic processes, different PRA, HLA match status, immunosuppressive protocols, small sample size, and ethnicity may be the main reasons for the inconsistent results of different studies [26,27]. …”
Section: Discussionmentioning
confidence: 99%
“…Many studies have investigated the association between cytokine gene polymorphisms and acute renal graft rejection, with different studies reporting different results. [1,3,5,17–25] The variable clinical diagnostic processes, different PRA, HLA match status, immunosuppressive protocols, small sample size, and ethnicity may be the main reasons for the inconsistent results of different studies [26,27]. …”
Section: Discussionmentioning
confidence: 99%
“…While several case-control studies have been conducted with large organ transplant cohorts, the identification of genotype/phenotype associations has been limited to the discoveries of polymorphisms with small effect, that have been reviewed in (16) , which have often not been replicated (1719) . Such studies have observed small average effects measured across groups of transplants when our study is measuring moderate effects in individual transplants.…”
Section: Discussionmentioning
confidence: 99%
“…Thirdly, some additional SNPs, e.g. IL6 -174G > C (rs1800795) and IL10 -592C > A (Lv et al,2012;Xiong et al,2015) were not included in this study because of incompatibility with the genotyping array, and insufficient DNA was available to carry out separate genotyping of these SNPs. In addition, other important innate immune genes, e.g.…”
Section: Discussionmentioning
confidence: 99%