The Impact of Green Tea Supplementation on Anthropometric Indices and Inflammatory Cytokines in Women with Polycystic Ovary Syndrome

Abstract

The present study aimed to determine the effect of a green tea supplement on anthropometric indices and inflammatory factors in women with polycystic ovary syndrome (PCOS). In this randomized clinical trial, 45 women with PCOS were randomly allocated into two groups receiving green tea tablets or placebo. The period of intervention was 45 days. The serum levels of interleukin 6, high-sensitivity C-reactive protein, and tumor necrosis factor α were measured before and after intervention period using the related kits. Anthropometric indices also were measured. The mean of body mass index, weight, waist circumference, and body fat percentage in the green tea group were reduced significantly. However, no significant difference was observed between the two groups. Also, there was no significant effect on the levels of inflammatory factors. The present results suggest that daily consumption of green tea tablets did not cause any effect on inflammation biomarkers in PCOS women. However, it may be effective as a complementary treatment for weight control in these women. Copyright © 2017 John Wiley & Sons, Ltd.

The effect of green tea on inflammatory mediators: A systematic review and meta‐analysis of randomized clinical trials

“…By considering criteria for inclusion and exclusion, 22 articles were excluded due to following reasons: not having a control group ( N = 3; Alghadir, Gabr, & Al‐Eisa, ; Lee et al, ; Sung et al, ), intervention less than 1 day ( N = 3; Alexopoulos et al, ; Hsu et al, ; Koutelidakis et al, ), and using other nutrients beside green tea in the intervention group ( N = 16; Bakker et al, ; Braga et al, ; Cialdella‐Kam et al, ; de Jesus Romero‐Prado et al, ; Dominiak, McKinney, Heilbrun, & Sarkar, ; Kim et al, ; Madaric et al, ; Nieman et al, ; Nieman et al, ; Ormsbee et al, ; Peluso et al, ; Rondanelli et al, ; Rubio‐Perez, Albaladejo, Zafrilla, Vidal‐Guevara, & Morillas‐Ruiz, ; Scolaro et al, ; Soriano‐Maldonado, Hidalgo, Arteaga, de Pascual‐Teresa, & Nova, ; Thomas, Williams, Sharma, Chaudry, & Bellamy, ; Figure ). Therefore, 17 articles were included in our systematic review (Basu et al, ; Bogdanski et al, ; de Maat et al, ; Dower et al, ; Fukino et al, ; Fukino, Shimbo, Aoki, Okubo, & Iso, ; Gutierrez‐Salmean et al, ; Hu et al, ; Hussain, Habib Ur, & Akhtar, ; Mielgo‐Ayuso et al, ; Mombaini & Jafarirad, ; Nogueira, Nogueira Neto, Klein, & Sanjuliani, ; Oyama et al, ; Oyama, Maeda, Sasaki, et al, ; Ryu et al, ; Shin et al, ; Sone et al, ); because the article by Ryu et al () did not report baseline values, we did not include it in our meta‐analysis (Table ). Interventions were performed by taking both green tea leaves and green tea extract.…”

“…In total, 16 articles with 887 participants measured hs‐CRP (Basu et al, ; Bogdanski et al, ; de Maat et al, ; Dower et al, ; Fukino et al, ; Fukino et al, ; Gutierrez‐Salmean et al, ; Hu et al, ; Hussain et al, ; Mielgo‐Ayuso et al, ; Mombaini & Jafarirad, ; Nogueira et al, ; Oyama, Maeda, Kouzuma, et al, ; Ryu et al, ; Shin et al, ; Sone et al, ), seven articles with 302 participants measured IL‐6 (Basu et al, ; de Maat et al, ; Dower et al, ; Mombaini & Jafarirad, ; Nogueira et al, ; Oyama, Maeda, Sasaki, et al, ; Ryu et al, ), and six articles with 256 participants measured TNF‐α (Bogdanski et al, ; de Maat et al, ; Dower et al, ; Mombaini & Jafarirad, ; Nogueira et al, ; Oyama, Maeda, Sasaki, et al, ).…”

“…The results of Egger's test provided no evidence of publication bias (Egger's test = 0.918). Findings from sensitivity analysis indicated that excluding some studies led to nonsignificant change in IL‐6 levels (Mombaini & Jafarirad, ; Oyama, Maeda, Sasaki, et al, ). Subgroup analysis identified study design, sex, study duration, and intervention type, but not tea polyphenols dosage, as the potential sources of heterogeneity ( p between subgroups <.01).…”

“…This might be the reason for the increasing effect of green tea on IL‐6. We should consider that these results were derived from just seven effect sizes with a significant heterogeneity, and by excluding some studies, significant effect of green tea changed to nonsignificant effect (Mombaini & Jafarirad, ; Oyama, Maeda, Sasaki, et al, ); therefore, getting firm conclusion is impossible.…”

Herbal medicinal products and obesity: A PTR virtual issue

“…Clinical trials focused on the effect of Ilex paraguariensis beverages on body weight and lipid profiles (Chaves et al, ), on the impact of green tea supplementation on anthropometric indices, including weight and body fat percentage in women with polycystic ovary syndrome (Mombaini, Jafarirad, Husain, Haghighizadeh, & Padfar, ), and finally, on the effect of quercetin supplementation (1 g/die) on metabolic and hormonal parameters in overweight or obese women with polycystic ovary syndrome (Khorshidi et al, ). Other clinical trials included in this virtual issues have described the effect of artichoke leaf extract and curcumin, a nutraceutical with a wide range of potential therapeutic applications (Kunnumakkara et al, ; Mantzorou, Pavlidou, Vasios, Tsagalioti, & Giaginis, ; Pagano, Romano, Izzo, & Borrelli, ; Soleimani, Sahebkar, & Hosseinzadeh, ) in subject with metabolic syndrome (Ghazimoradi et al, ; Mohammadi et al, ; Rezazadeh, Rahmati‐Yamchi, Mohammadnejad, Ebrahimi‐Mameghani, & Delazar, ).…”