The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

Landau, Ruth; Ortner, Clemens; Vuilleumier, Pascal Henri

doi:10.1007/s40140-013-0029-2

Cited by 3 publications

(2 citation statements)

References 89 publications

(104 reference statements)

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“…An increasing number of studies strongly suggest that genetic predisposition plays an important role in pain and pain-related mechanisms [36]. Gender-genotype and ethnicity-dependent genetic interactions have been shown to exist, indicating that we cannot generalise findings from different cohorts and extrapolate from one study population to another [37]. Other limitations that could impact results are self-rated pain and VAS scores collected within 24 h after delivery.…”

Section: Discussionmentioning

confidence: 99%

Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour

Šanjug,

Kuna,

Goldštajn

et al. 2023

JCM

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Background: The COMT gene polymorphism is associated with neurological and psychiatric disorders and pain perception. The present study investigates the existence of anxiety and pain perception in relation to the COMT (catechol-O-methyltransferase) gene polymorphism in labouring women (during “natural” childbirth) with or without inhaled analgesia. Methods: A total of 181 women who chose vaginal birth were enrolled in this study. To present the difference in pain perception, the parturients were divided into one group (n = 90) that chose labour analgesia with inhaled nitrous oxide (50% nitrous oxide and 50% oxygen) and one group (n = 91) without analgesia. The blood samples were taken during the pregnancy as a part of routine pregnancy controls in the hospital. The COMT gene polymorphism was detected with the PCR technique. The pain perception of parturients was self-evaluated two times according to the VAS (Visual Analogue Scale), and anxiety as a personality trait was determined with the STAI-T (State Trait Anxiety Inventory). Pain perception as well as anxiety were compared according to COMT genotypes. Results: In the 181 pregnant women, there were 40 women (22%) of wild homozygotes (GG) of COMT, 95 women (53%) of mutant heterozygotes (GA), and 46 women (25%) of mutant homozygotes (AA). A negative association of pain perception with the GA (mutant heterozygote) polymorphism of the COMT gene versus the wild-type (GG polymorphism) was observed. The GA polymorphism of the COMT gene was associated with 0.46 units lower pain perception compared to the wild type (GG). The anxiety trait score in group AA was lower than in groups GA and GG. The difference reached statistical significance only when comparing AA versus GA (p > 0.042). Analgesic efficacy of nitrous oxide was noticed in 22% of labouring women who reported moderate pain (VAS score 4–7). Conclusions: The COMT gene polymorphism was associated with pain perception and anxiety among parturients. The COMT gene polymorphism GA was associated with negative pain perception among labouring women. Nitrous oxide showed statistical significance in anxiolytic efficacy during labour in women with mild anxiety as a personality trait. Anxiolytic efficacy of nitrous oxide has shown better efficacy in parturients with the COMT gene polymorphism AA.

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Section: Discussionmentioning

confidence: 99%

Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour

Šanjug,

Kuna,

Goldštajn

et al. 2023

JCM

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“…Labour is recognized as being desired experiences in life [1]. An important feature of childbirth is pain [2].…”

Section: Introductionmentioning

confidence: 99%

Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

Kafshdooz

Kahroba

Kafshdooz

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Labour is considered to be one of the most painful procedures in human experience. The most effective technique for pain relief during labour is neuraxial labour analgesia which provides analgesia without maternal or fetal sedation. Genetic predisposition may be of importance for pain perception and women experience varying degrees of pain in labour. Genetic variations in opioid receptor (OPR) genes may influence the response to epidural opioid analgesia during labour. The single-nucleotide polymorphism, A118G of the mu opioid receptor gene (oprm1), has been associated with altered pain perception. Targeted drug delivery reduces toxic side effects. Liposomes, nano-particles, nanofibres hydrogel, have been suggested to deliver anaesthetic drugs.

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OB/GYN anesthesia: Finding the best and safest arrows in the quiver

Vuilleumier

2018

Trends in Anaesthesia and Critical Care

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The Impact of Genetics and Other Factors on Intra- and Post-partum Pain

Cited by 3 publications

References 89 publications

Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour

Relationship between COMT Gene Polymorphism, Anxiety, and Pain Perception during Labour

Labour analgesia; Molecular pathway and the role of nanocarriers: a systematic review

OB/GYN anesthesia: Finding the best and safest arrows in the quiver

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