The Impact of Gender on Caries Prevalence and Risk Assessment

Martínez-Mier, E. Ángeles; Zandoná, Andréa Ferreira

doi:10.1016/j.cden.2013.01.001

Cited by 70 publications

(67 citation statements)

References 97 publications

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“…It has already been reported in the literature that females are more exposed to dental caries than males, and it was proposed that this difference is caused by biological and anthropological factors such as social and dietary behaviours, hormonal differences, eruption characteristics, tooth and saliva characteristics as well as genetic factors [Vieira et al, 2008;Ferraro and Vieira, 2010;Lukacs, 2011;Martinez-Mier and Zandona, 2013].…”

Section: Resultsmentioning

confidence: 99%

Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy

et al. 2016

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Background: The DEFB1 gene, encoding for the constitutively expressed human β-defensin 1 (hBD1) antimicrobial peptide is a potential candidate when studying genetic susceptibility to caries. DEFB1 genetic variations have been reported as contributing to hBD1 production impairment, leading to a greater susceptibility to be infected by oral pathogens, also leading to periodontitis. Methods: We analysed 5 DEFB1 polymorphisms, namely 3 functional single-nucleotide polymorphisms (SNPs) at the 5′-untranslated region (UTR), -52G>A (rs1799946), -44C>G (rs1800972), and -20G>A (rs11362), 2 SNPs at the 3′-UTR, c*5G>A (rs1047031) and c*87A>G (rs1800971) SNP located in potential miRNA binding sites, looking for possible correlations with the risk to develop caries in 654 adult subjects from isolated populations of north-eastern Italy. Dental caries prevalence was evaluated with the DMFT (decayed, missing, filled teeth) index, calculated after an accurate oral examination. DEFB1 SNP genotyping was performed with an Illumina 370k high-density SNP array. Results: Two DEFB1 SNPs were significantly associated with the DMFT index: the strongest association emerged from rs11362 SNP (p = 0.008). In particular G/G homozygous individuals showed a higher DMFT index compared to both G/A heterozygous and A/A homozygous individuals; rs1799946 SNP was also significantly associated with DMFT (p = 0.030), and individuals homozygous for the T allele had a higher DMFT value compared to heterozygous C/T and homozygous C/C individuals. Conclusions: Our study replicated, on a larger number of individuals, previous findings showing the association between two 5′-UTR SNPs in the DEFB1 gene and DMFT, suggesting that these polymorphisms could be considered as potential markers for assessing the risk to develop caries.

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Section: Resultsmentioning

confidence: 99%

Caries and Innate Immunity: DEFB1 Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy

et al. 2016

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“…Em relação ao gênero, as mulheres estão em desvantagem, devido a fatores genéticos, hormonais e culturais. Porém, ainda há falta de evidências que provem a relação da doença ao gênero 10 . A reabsorção do osso alveolar é um dos defeitos ósseos ou sequelas frequentemente causados pela doença periodontal.…”

Section: Discussionunclassified

Perfil dos laudos de exames radiográficos intrabucais realizados no sul catarinense

et al. 2017

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RESUMOIntrodução: O exame radiográfico pode ser essencial para o diagnóstico das doenças bucais assintomáticas e na confirmação de sinais e sintomas clínicos. Buscou-se verificar o perfil epidemiológico dos pacientes, do Sistema Único de Saúde do município de Criciúma/SC, submetidos a exames radiográficos intrabucais, realizados por uma clínica de radiologia odontológica particular. Objetivo: Buscou-se caracterizar os pacientes atendidos pelo Sistema Único de Saúde em um município Sul Catarinense, e submetidos a exames radiográ-ficos intrabucais. Método: Foi realizado um estudo transversal, descritivo, com abordagem quantitativa, com uma amostra de 576 radiografias intrabucais, distribuídas em 290 laudos, no período de um ano. Resultados: A cárie (61,5%) foi a doença mais frequente e, entre os achados radiográficos, as cristas alveolares normais as mais prevalentes (43,7%). A doença cárie foi significativamente associada ao gênero (p=0,001), sendo mais frequente no feminino (58,7%). Houve associação estatisticamente significativa da idade dicotomizada em relação a cárie e as cristas alveolares normais (ambos com p<0,001), mais frequentes em indivíduos mais jovens. Conclusões: O perfil predominante foi composto por mulheres adultas de meia idade, a cárie foi a mais frequente entre as lesões e as cristas alveolares entre os achados radiográficos. Descritores: Epidemiologia • Radiografia • Diagnóstico. ABSTRACTIntroduction: Radiographic examination may be essential for the diagnosis of asymptomatic oral diseases and confirmation of clinical signs and symptoms. It was attempted to verify the epidemiological profile of patients, the Health System in the city of Criciuma/SC, submitted to intra-oral radiographic examinations by a private dental radiology clinic. Objective: It was attempted to verify the patients attended in the Sistema Único de Saúde in the South of Santa Catarina state, submited to intra-oral radiographs. Methods: It was conducted a cross-sectional descriptive study with a quantitative approach, from a sample of 576 intra-oral radiographs, distributed in 290 reports, within one year. Results: Caries (61.5%) were the most common disease and among the radiographic findings, normal alveolar ridges (43.7%). The caries was significantly associated with gender (p = 0.001), being more frequent in females (58.7%). There was a statistically significant association between dichotomized age in relation to decay and the normal alveolar ridges (both p <0.001), more common in younger individuals. Conclusions: The profile was composed of adult middle-aged women, caries were the most frequent among the injury and the alveolar ridges among the radiographic findings. Descriptors: Epidemiology • Radiography • Diagnosis.

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“…The differences are suggested to be the consequence of sex disparities and bias related to the risk factors modulating dental caries [47]. On the other hand, men appear more commonly to have faster hearing deterioration, in part due to the types of occupations that favor males [48].…”

Section: Discussionmentioning

confidence: 99%

Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay

et al. 2014

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BackgroundCongenital forms of hearing impairment can be caused by mutations in the estrogen related receptor beta (ESRRB) gene. Our initial linkage studies suggested the ESRRB locus is linked to high caries experience in humans.MethodsWe tested for association between the ESRRB locus and dental caries in 1,731 subjects, if ESRRB was expressed in whole saliva, if ESRRB was associated with the microhardness of the dental enamel, and if ESRRB was expressed during enamel development of mice.ResultsTwo families with recessive ESRRB mutations and DFNB35 hearing impairment showed more extensive dental destruction by caries. Expression levels of ESRRB in whole saliva samples showed differences depending on sex and dental caries experience.ConclusionsThe common etiology of dental caries and hearing impairment provides a venue to assist in the identification of individuals at risk to either condition and provides options for the development of new caries prevention strategies, if the associated ESRRB genetic variants are correlated with efficacy.

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The Impact of Gender on Caries Prevalence and Risk Assessment

Cited by 70 publications

References 97 publications

Caries and Innate Immunity: <b><i>DEFB1</i></b> Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy

Caries and Innate Immunity: <b><i>DEFB1</i></b> Gene Polymorphisms and Caries Susceptibility in Genetic Isolates from North-Eastern Italy

Perfil dos laudos de exames radiográficos intrabucais realizados no sul catarinense

Role of estrogen related receptor beta (ESRRB) in DFN35B hearing impairment and dental decay

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