The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and meta-analysis

Lipsett, Andrea; Barrett, Sarah; Haruna, Fatimah; Mustian, Karen M.; O’Donovan, Anita

doi:10.1016/j.breast.2017.02.002

Cited by 174 publications

(149 citation statements)

References 54 publications

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“…Twelve meta-analyses included only studies that involved cancer survivors who had lung resection,26 73 chemotherapy or radiation therapy,24 25 69 only chemotherapy,65 only radiation therapy,75 only androgen deprivation therapy,66 stem cell transplantation,53 60 induction therapy or postremission therapy80 and breast cancer surgery 52. The remaining meta-analyses did not use treatment stage or type as eligibility criteria and included a variety of treatment stages and types.…”

Section: Resultsmentioning

confidence: 99%

Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials

Fuller¹,

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials

Fuller¹,

et al. 2018

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“…Interventions including physical activity and psychological and pharmacologic approaches have been investigated for the management of fatigue in cancer patients, and several systematic reviews have been published [14][15][16][17][18][19][20][21][22] . The evaluation of pharmacologic interventions is particularly important, because medications can be associated with adverse effects and high costs.…”

Section: Introductionmentioning

confidence: 99%

Pharmacologic Interventions for Fatigue in Cancer and Transplantation: A Meta-Analysis

et al. 2018

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“…Importantly, neurorehabilitation can even support the continued improvement in function and quality of life for a stroke survivor during continued neurorehabilitation after recovery from cancer surgery and radiation. In the case of Ms. White, downwardly spiraling sequelae did not occur; rather, by month 10 of the neurorehabilitation program, most measures of function and quality of life were on an improvement trend, as had been occurring prior to the cancer treatment [13][14].…”

Section: Discussionmentioning

confidence: 91%

Feasibility and benefit of long-dose stroke neurorehabilitation which produced and maintained balance and mobility gains throughout cancer surgery and radiation treatment

Boissoneault¹,

Khanna²,

Daly³

2018

Vascul Dis Ther

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Purpose: This case study provides quantitative evidence of the feasibility and benefit of a long-dose, 10-month neurorehabilitation program for a chronic stroke survivor who, in the midst of the neurorehabilitation program, underwent surgery and radiation treatment for breast cancer. Methods:The patient was age 60 years, and 6 years post-stroke (left middle cerebral artery stroke), exhibiting impairments in balance, strength, and gait coordination, as well as deficits in functional mobility, and compromised quality of life. Her comprehensive mobility/fitness neurorehabilitation program included aerobics, strength and coordination training, and balance and gait coordination training. Treatment was 1.5 -2 hours per day, 5 days/week for 6 months, followed by an additional 4 months of treatment 3 days/week. Outcome measures were acquired at entry into the neurorehabilitation program, and at months 2, 4, 6, 8 and 10. Measures included the following: modified Ashworth (mASH, spasticity); Fugl-Meyer (FM; isolated limb joint coordination); 6-minute walk test (6MWT; walking endurance); gait speed; Berg Balance Scale (BBS; static and dynamic balance); Timed Up and Go (TUG; mobility); 10 Meter Walk Test (10MWT; short distance, self-selected and fast walking speed); Functional Gait Assessment (FGA; dynamic balance and postural stability during gait); Functional Independence Measure (FIM; assessment of functional status and disability); Craig Handicap Assessment and Reporting Technique (CHART; quality of life assessment of how patients with disabilities function in the community and at home); 36-Item Short Form Survey (SF36; quality of life measure); and the Stroke Impact Scale (SIS; stroke-specific quality of life measure). Fatigue level was queried during and following radiation therapy.Results: From baseline through month 4, the patient demonstrated improvements in most outcome measures. For example, she improved from 3 minutes of cycling endurance to 45 minutes, and balance improvement reached the threshold for functional independence. At month 5, she was diagnosed with breast cancer and underwent a partial mastectomy. She underwent radiation treatment, which concluded in month 7. Prior, during, and after the cancer treatment, she continued participation in the neurorehabilitation program.Following the partial mastectomy, she exhibited continued improvement in BBS, 10MWT-normal speed, FGA, CHART, SF-36, and SIS. Notably, the TUG continued to improve significantly by 4.73sec. She showed some decline in values for the 6MWT, gait speed, and 10MWT-fast walking speed.Four weeks following the end of the course of radiation therapy, most measures showed a small decline. But in contrast, by 12 weeks after the end of radiation (which coincided with 10 months of participation in the neurorehabilitation program), the following measures showed a revival in improvement: Fugl-Myer (limb coordination); 6MWT (walking endurance); gait speed; BBS (balance); FIM (functional tasks); subdomains of the CHART quality of life measure (p...

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The impact of exercise during adjuvant radiotherapy for breast cancer on fatigue and quality of life: A systematic review and meta-analysis

Abstract: Exercise during adjuvant RT can be considered beneficial in breast cancer patients. Supervised, combined aerobic-resistance exercise shows promise in alleviating fatigue with further investigation into alternative exercise modes required.

Cited by 174 publications

References 54 publications

Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials

Therapeutic effects of aerobic and resistance exercises for cancer survivors: a systematic review of meta-analyses of clinical trials

Pharmacologic Interventions for Fatigue in Cancer and Transplantation: A Meta-Analysis

Feasibility and benefit of long-dose stroke neurorehabilitation which produced and maintained balance and mobility gains throughout cancer surgery and radiation treatment

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