The Impact of Environmental and Agricultural Pollutants on the Prevalence of Allergic Diseases in People from Qassim , KSA

Elshabrawy, Walaa Othman; Ismail, Hisham; Hassanein, Khaled

doi:10.12816/0006068

Cited by 8 publications

(6 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is of major concern that the nasal epithelial cells of nonallergic subjects reacted via an inflammatory response to the combination of NO 2 and Der p 1, which may be an initial step in allergen sensitization. These findings are in line with the environmental studies of Elshabrawy et al [29], and to our knowledge this is the first in vitro study to analyze the impact of volatile air pollution on human cellular reactions to aeroallergens. …”

Section: Discussionsupporting

confidence: 91%

“…Studies considering a synergistic effect of both a major allergen and a volatile reactive gas are rare. A recent study by Elshabrawy et al [29] examined the impact of environmental and agricultural pollutants on the prevalence of allergic diseases. The authors demonstrated that subjects which are highly exposed to environmental and agricultural pollution are at a high risk for developing allergies.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1

Koehler

Paulus

Ginzkey

et al. 2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Asthma and allergies are both major global health problems with an increasing prevalence, and environmental data implicate an influence of air pollutants on their development. The present study focuses on the influence of nitrogen dioxide (NO₂) and the major allergen of the house dust mite Der p 1 on human nasal epithelial cells of nonallergic patients in vitro. Nasal epithelial mucosa samples of 11 donors were harvested during nasal air passage surgery and cultured as an air-liquid interface. Exposure to 0.1, 1 and 10 ppm NO₂ or synthetic air as a control was performed for 1 h. Subsequently, the cells were exposed to Der p 1 for 24 h. The release of interleukin (IL)-6 and IL-8 was measured by ELISA, and the production of IL-6 mRNA and IL-8 mRNA was measured by RT-PCR. NO₂ exposure resulted in a concentration-dependent release of IL-6, but not IL-8 release. The coexposure of 0.1 ppm NO₂ and Der p 1, or 1 ppm NO₂ and Der p 1 significantly increased both IL-6 and IL-8 release. Exposure to NO₂, Der p 1, or their combination, did not significantly influence the production of IL-6 or IL-8 mRNA. In conclusion, NO₂ increases the release of inflammatory cytokines in human nasal epithelial cells, especially in coexposure with Der p 1, as a mechanism of allergotoxicology.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1

Koehler

Paulus

Ginzkey

et al. 2016

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…The clinically relevant prevalence of mango allergy was 0.29%. This prevalence was lower compared to Shaoguan, China (1.4%) [45], Taiwan, China (18.5%) [20], and Japan (12.5%) [21]. Apple allergy in our study was confirmed in 0.1% of the patients.…”

Section: Discussioncontrasting

confidence: 52%

“…Mango and apple allergy are rare in European countries but are common in China and some other countries of East Asia. Data have shown that the mango allergy rate in Taiwan, China [20] is 18.5%, and 12.5% in Japan [21]. The incidence of apple allergies is lower compared to mango allergies, but anaphylactic shock is often reported [22].…”

Section: Introductionmentioning

confidence: 99%

Skin Prick Testing to Identify Food Allergens in 8393 Children and Adolescents with Asthma in Chongqing, Southwest China

2019

View full text Add to dashboard Cite

BackgroundThe prevalence of food allergies in asthmatic children and adolescents has significantly increased over recent years. Nevertheless, the relevant clinical analyses are still lacking in China. Therefore, the present study aimed to determine common food allergens in pediatric patients with asthma in Chongqing, Southwest China.Material/MethodsA total of 8393 asthmatic patients from Children’s Hospital of Chongqing Medical University (CHCMU) were enrolled in this retrospective study between October 2014 and July 2017. All patients underwent skin prick test (SPT) with 10 food allergens and recorded history of clinical reactivity. The correlations among the positive rates, categories of allergens, gender, age, and living environment were analyzed.ResultsA total of 2544 patients (30.31%) had a positive SPT, while the prevalence of food allergy was 8%. Sea crab, peanut, and sea shrimp were the most common food allergens found in the studied population. The frequent food allergies were sea crab, peanuts, and sea shrimp.ConclusionsIdentifying allergens is important for the diagnosis and management of allergic disorders, and for performing immunotherapy.

show abstract

“…All insect matter like wings, scales, saliva, dried fecal matter, and venom can cause allergic diseases such as rhinitis, conjunctivitis, asthma, urticaria and gastric disorders 14,15 . Depending on the route of sensitization, the insect allergens have been recognized as an inhalant, ingestant and injectant allergens 16.…”

Section: Bacallergy and Insectmentioning

confidence: 99%

A review on Respiratory allergy caused by insects

Kausar¹

2018

Bioinformation

View full text Add to dashboard Cite

Hypersensitivity or allergy encompasses a wide range of immunological reactions that generally have adverse consequences involving one or many organ systems of the body. Allergens are usually glycoprotein or chemically complex low molecular weight substances. The common allergens include pollen, fungal spores, house dust mite and house dust, animal danders, drugs, foods, insect emanations, and detritus, etc. Information on the role of insects in respiratory allergy is increasing in the literature. There are about 30 million living species of insects. These insects can broadly be classified as stinging insects, biting insects and non-stinging and non-biting insects. All materials form insets namely wings, scales, saliva; dried feces and venom can cause allergic diseases, such as rhinitis, conjunctivitis, asthma and urticaria. There are wide varieties of insects such as moths, butterflies, bees, wasps, hornets, yellow jackets, flies, beetles, cockroaches, and mosquitoes. Exposure to emanations and detritus of these insects may lead to several allergies in some genetically predisposed individuals. Therefore, it is of interest to review allergies caused by various insect’s stings and bites and their adverse effect on the human body.

show abstract

The Impact of Environmental and Agricultural Pollutants on the Prevalence of Allergic Diseases in People from Qassim , KSA

Cited by 8 publications

References 25 publications

The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1

The Proinflammatory Potential of Nitrogen Dioxide and Its Influence on the House Dust Mite Allergen Der p 1

Skin Prick Testing to Identify Food Allergens in 8393 Children and Adolescents with Asthma in Chongqing, Southwest China

A review on Respiratory allergy caused by insects

Contact Info

Product

Resources

About