The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

Zhou, Cuihong; Xue, Fen; Shi, Qingqing; Xue, Shan-Shan; Zhang, Tian; Ma, Xinxu; Yu, Lisheng; Liu, Chuang; Wang, Huaning; Peng, Zhengwu

doi:10.3389/fnmol.2022.812479

Cited by 5 publications

(10 citation statements)

References 118 publications

(128 reference statements)

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“…In the same time, the variable importance in the projection (VIP) values was obtained from each lipid variable to examine the contribution of variables, and the Student’s t -test followed by the adjustment of the false discovery rate (FDR) in multiple hypothesis tests was introduced to obtain the P values of each variable. Lipids with significant differences were identified based on a combination of fold change (> 1.5 or < 0.67), Student’s t -test FDR < 0.01, and VIP > 1 in according to the methods from our previous reports (Xue et al, 2020 ; Zhou et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome

Zhou

Zhao²,

Ma³

et al. 2023

Front. Cell. Neurosci.

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Introduction: Compelling evidence indicates that a single sub-anesthetic dose of (S)-ketamine elicits rapid and robust antidepressant effects. However, the underlying mechanisms behind the antidepressant effects of (S)-ketamine remain unclear.Methods: Here, using a chronic variable stress (CVS) model in mice, we analyzed changes inthe lipid compositions of the hippocampus and prefrontal cortex (PFC) with a mass spectrometry-based lipidomic approach.Results: Similar to previous research outcomes, the current study also showed that (S)-ketamine reversed depressive-like behaviors in mice produced by CVS procedures. Moreover, CVS induced changes inthe lipid compositions of the hippocampus and PFC, notably in the contents of sphingolipids, glycerolipids, and fatty acyls. With the administration of (S)-ketamine, CVS-induced lipid disturbances were partially normalized, particularly in the hippocampus.Conclusion: Altogether, our results indicated that (S)-ketamine could rescue CVS-induced depressive-like behaviors in mice through region-specific modulation of the brain lipidome, contributing to the understanding of (S)-ketamine’s antidepressant effects.

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Section: Methodsmentioning

confidence: 99%

Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome

Zhou

Zhao²,

Ma³

et al. 2023

Front. Cell. Neurosci.

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“…A total of 56 studies were included, with 19 clinical studies and 37 animal studies. Two studies (Prisco et al, 2013 ; King Heather et al, 2015 ) used ear acupuncture, one study (Wu et al, 2013 ) used scalp acupuncture, one study (Yang et al, 2022 ) used CO 2 laser stimulation, one study (Feng et al, 2019 ) used TEAS, and other studies (Fang et al, 2012 ; Li, 2012 , 2014 , 2018 , 2020 ; Wang et al, 2012 , 2015 ; Hou et al, 2013a , b , 2021 ; Wang, 2013 , 2019 ; Engel et al, 2014 ; Li and Zhao, 2014 ; Zhao et al, 2014 , 2019 , 2020 ; Xie et al, 2015 ; Zheng, 2015 ; Zheng et al, 2015 ; Zhou et al, 2015 , 2019 ; Lu et al, 2016 ; Zhu et al, 2016 , 2022 ; Han, 2017 ; Li et al, 2017 , 2020a , b ; Ding, 2018 ; Oh et al, 2018 ; Zhao Y. et al, 2018 ; Zhao Z. et al, 2018 ; Chen et al, 2019 , 2020 , 2021 ; Liu et al, 2019 , 2020 ; Moiraghi et al, 2019 ; Wei et al, 2019 ; Xue et al, 2019 ; Yu et al, 2019 ; Zhang et al, 2019 ; Zhu and Lu, 2019 ; Alvear, 2021 ; Hollifield et al, 2021 ; Abanes et al, 2022 ; Lee and Pan, 2022 ; Song et al, 2022 ; Sun Y. et al, 2022 ; Zhou C. et al, 2022 ) used filiform needle (detail in…”

Section: Resultsmentioning

confidence: 99%

“…The stimulation parameters should reflect the amount of stimulation received rather than the amount of stimulation applied, and judging the actual amount of electroacupuncture effect received by animals is difficult. Furthermore, animals mostly receive acupuncture while under anesthesia, whereas patients receive acupuncture while awake, which may have an impact on acupuncture translational medicine (Zhou C. et al, 2022 ).…”

Section: Resultsmentioning

confidence: 99%

Efficacy and underlying mechanisms of acupuncture therapy for PTSD: evidence from animal and clinical studies

Tang

Lin

Fang

et al. 2023

Front. Behav. Neurosci.

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As a major public health problem, posttraumatic stress disorder (PTSD) has a substantial impact on individuals and society. The total excess economic burden of PTSD in the US is estimated to be more than $232.2 billion a year. Acupuncture is widely used in patients with PTSD, and an increasing number of studies have been undertaken to assess the efficacy and underlying mechanisms of acupuncture for the treatment of individuals with PTSD. However, there has not yet been a review that simultaneously elucidates the therapeutic efficacy and biological mechanisms of acupuncture. We wished to examine the efficacy and underlying mechanisms of acupuncture for the treatment of individuals with PTSD. We conducted this review in three sections as follows: a meta-analysis, an acupoint analysis, and mechanism research. PubMed, Web of Science, Embase, Cochrane Library, China National Knowledge Infrastructure Database (CNKI), WanFang Database, China Biology Medicine Database (CBM), Chinese Science and Technology Journals Database (VIP), and other databases were searched from 1 January 2012 to 27 November 2022. Based on the included studies, we first determined whether acupuncture is more effective than psychological treatment or pharmacological treatment for treating and improving the quality of life of individuals with PTSD by meta-analysis. Second, the most commonly used acupoints and parameters of acupuncture were summarized based on animal and clinical studies. Third, we attempt to summarize the current mechanisms of acupuncture in the treatment of PTSD. Finally, 56 acupoint analyses, eight meta-analyses, and 33 mechanistic studies were included. Acupuncture outperformed pharmacotherapy treatment in improving symptom scores by CAPS, HAMA, HAMD, PCL-C, and SCL-90 somatization for PTSD and outperformed psychotherapy treatment in improving symptom scores by CAPS PCL-C and HAMD, according to the meta-analysis. GV20 was the most frequently used acupuncture point in clinical studies and animal studies, with a 78.6% application rate. Acupuncture may be effective in treating PTSD by regulating the structure and components of several brain areas, regulating the neuroendocrine system, and involving signaling pathways. In conclusion, this finding indicates that acupuncture has promising potential for treating PTSD.

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“…There are few studies on the effects of electroacupuncture on sphingolipid metabolism in skin repair. However, other studies have shown that electroacupuncture can regulate the changes of lipid metabolism in mice with post‐traumatic stress disorder, especially the content changes of sphingolipids, glycerides and fatty acyl groups 34 . In the sphingomyelinase pathway, CER is formed by hydrolysis of sphingomyelins in the granular layer of the skin by sphingomyelinase.…”

Section: Discussionmentioning

confidence: 99%

Serum lipidomics‐based study of electroacupuncture for skin wound repair in rats

Wang

et al. 2023

J Cellular Molecular Medi

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Lipid metabolism plays an important role in the repair of skin wounds. Studies have shown that acupuncture is very effective in skin wound repair. However, there is little knowledge about the mechanism of electroacupuncture. Thirty‐six SD rats were divided into three groups: sham‐operated group, model group and electroacupuncture group, with six rats in each group. After the intervention, orbital venous blood was collected for lipid metabolomics analysis, wound perfusion was detected and finally the effect of electroacupuncture on skin wound repair was comprehensively evaluated by combining wound healing rate and histology. Lipid metabolomics analysis revealed 11 differential metabolites in the model versus sham‐operated group. There were 115 differential metabolites in the model versus electro‐acupuncture group. 117 differential metabolites in the electro‐acupuncture versus sham‐operated group. There were two differential metabolites common to all three groups. Mainly cholesteryl esters and sphingolipids were elevated after electroacupuncture and triglycerides were largely decreased after electroacupuncture. The electroacupuncture group recovered faster than the model group in terms of blood perfusion and wound healing (p < 0.05). Electroacupuncture may promote rat skin wound repair by improving lipid metabolism and improving local perfusion.

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The Impact of Electroacupuncture Early Intervention on the Brain Lipidome in a Mouse Model of Post-traumatic Stress Disorder

Cited by 5 publications

References 118 publications

Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome

Effects of (S)-ketamine on depression-like behaviors in a chronic variable stress model: a role of brain lipidome

Efficacy and underlying mechanisms of acupuncture therapy for PTSD: evidence from animal and clinical studies

Serum lipidomics‐based study of electroacupuncture for skin wound repair in rats

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