An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C-H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners.
The solubility of fumaric acid in propan-2-ol, ethanol, acetone, and propan-1-ol was measured by a synthetic method at temperatures ranging from (279 to 352) K at atmospheric pressure. The laser monitoring observation technique was used to determine the disappearance of the solid phase in a solid + liquid mixture. The results of these measurements were correlated by a modified Apelblat equation.
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