The impact of early intensive glucose control for prophylaxis of complications of type 2 diabetes mellitus (results of UKPDS study and 10-year follow-up study)

Abstract

At the present time diabetes mellitus (DM) is a main noninfectious disease that not only significantly influences quality of life and life expectancy of every patient but also represents a heavy burden for the healthcare system. Medico social significance of DM is defined by high prevalence of this disease in population and high risk of its specific macro- and microvascular complications. According to latest data the main chain in the development of all specific complications of DM is chronic hyperglycemia, the important role belongs also to arterial hypertension and dyslipidemia. The multicenter randomized controlled study UKPDS assessed the influence of levels of hyperglycemia and arterial pressure as well as common methods of their corrections on development of complications of type 2 DM. The results of the UKPD study showed the significance of the intensive control of blood glucose and arterial pressure for the prophylaxis of type 2 DM complications and lethal outcomes. These observations allowed development of contemporary recommendations for treatment patients with type 2 DM and defined the target levels of HbAlc (

Determination of 3-Hydroxy-3-Pyrroline-2-One in Urine and Study of Its Excretion From the Organism of Laboratory Animals

“…It is known that almost any disease of the central nervous system is accompanied by the development of cognitive disorders, which are manifested by decrease in memory, attention and mental performance. Cognitive disorders adversely affect the quality of life of the patient and need correction [1]. The drugs of choice in the complex therapy in this case are nootropics.…”

“…Известно, что практически любое заболевание со стороны центральной нервной си-стемы сопровождается развитием когнитивных рас-стройств, которые проявляются в снижении памяти, внимания и умственной работоспособности. Когни-тивные расстройства негативно сказываются на каче-стве жизни пациента и нуждаются в коррекции [1]. Препаратами выбора в составе комплексной терапии в данном случае являются ноотропы.…”