“…In 2005 and 2008, this program was modified to perform screening during the first or second trimester and to use a combined test for nuchal translucency thickness, hCG and pregnancy‐associated plasma protein‐A (PAPP‐A) or the quadruple test (hCG, AFP, uE3, and inhibin A) (Chou et al, , Shaw et al, , Shaw et al, ). The first and second trimester DS screening percentage is approximately 48.7% in Taiwan (Lin et al, ). According to the literature, the detection rate for the second trimester double test is 56‐61%, the first trimester combined test is 82.0–87.5%, and the second trimester quadruple test is 81% in Taiwan (Shaw et al, , Shaw et al, ).…”