The impact of depression and anxiety in prognosis of patients undergoing myocardial perfusion imaging with 99mTc tetrofosmin SPECT for evaluation of possible myocardial ischemia

Abstract

Background:The goal of this study was to evaluate the prevalence of depression and anxiety in patients subjected to myocardial perfusion imaging (MPI) with 99m Tc tetrofosmin stress-rest single-photon emission computer tomography (SPECT), and their impact on their cardiological events or disease. material and methods: Patients referred to the Nuclear Medicine Department for 99m Tc tetrofosmin myocardial MPI-SPECT were asked to fulfill the Zung Self-Rating Depression Scale (ZDS) and Hamilton anxiety questionnaire (HAQ). Among 213 patients who completed the ZDS and HAQ, 80 patients (59 males and 21 females) were selected for this study because they had no known psychological disease, other disease that could influence psychological status, or use of narcotic drugs. Collected data from MPI and psychological status were subsequently analyzed. results: Among all 80 patients, 52 patients (65%) had abnormal MPI of whom 28/52 (53.8%) exhibited either depression, anxiety or both, and 28 (35%) patients had normal MPI of whom 10/28 (35.7%) had abnormal psychological status. The higher number of patients with abnormal psychological status in association with abnormal MPI was noted predominantly in patients with previously established coronary artery disease. A correlation was also noted between obesity, cardiac heredity and depression or anxiety in patients with abnormal MPI. conclusions: Patients that exhibit depression, anxiety, or both, have high rates of myocardial ischemia, and thus are at risk for subsequent cardiological events.

Vitamin D Deficiency as a Risk Factor for Myocardial Ischemia

“…In most cases, an abnormal MPI indicates myocardial ischemia due to coronary artery disease. However, several other non-cardiac conditions may coexist, such as depression, anxiety, or Vit D deficiency, which may affect myocardial function and lead to an abnormal MPI without coronary artery disease [ 27 , 28 ].…”

“…Aberrant MPI SPECT denoting ischemia was deemed to be when SSS was ≥4. Myocardial ischemia was considered as mild when SSS was 4 to 8, moderate 9 to 13, and serious with SSS > 13 [ 27 ].…”

“…Myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT), is a noninvasive functional imaging method used in several diseases for myocardial evaluation [ 24 , 25 , 26 ]. MPI can image myocardial ischemia in patients even in the absence of specific cardiac symptomatology [ 27 , 28 , 29 ]. The diagnostic accuracy of MPI SPECT compared with conventional coronary angiography is similar for both men and women, with a mean sensitivity and specificity of 84.2% and 78.7% for SPECT MPI in women, and 89.1% and 71.2% for MPI SPECT in men, respectively [ 30 ].…”

Single photon emission computed tomography myocardial perfusion imaging in patients with moderate to severe psoriosissis

“…Forty minutes later, the images were acquired via a 90°-angled dual-head camera, using a collimator with 64 stops and 25 s per projection over a 180° arc. Subsequently, the images were reconstructed without attenuation correction as previously reported [9].…”

To Screen or Not to Screen? At Which BMI Cut Point? Comment on “Obesity and BMI Cut Points for Associated Comorbidities: Electronic Health Record Study”

“…In our recent study [ 2 ], although of a different concept, we prospectively evaluated a cohort of 80 patients who were subjected to myocardial perfusion imaging for myocardial ischemia evaluation. All patients in the study were additionally evaluated for the presence of anxiety and depression.…”