Background: Climate change is a significant threat to the health of the Ghanaian people. Evidence abounds in Ghana that temperatures in all the ecological zones are rising, whereas rainfall levels have been generally reducing and patterns are increasingly becoming erratic. The study estimated the impact of climate change on biochemical markers of renal disease.Methods: This study recruited 50 conveniently sampled apparently health peasant farmers and hawkers at the market place at Wa in the Upper West Region of Ghana. A pre-study screening for hepatitis A and C, diabetes, hypertension, was done. Serum creatinine and urea levels were analyzed to rule out kidney defects. Baseline data was collected by means of analysing blood samples for renal function (i.e. urea, creatinine, sodium, potassium, eGFR) as well as for hemoglobin (Hb) and hematocrit (Hct) concentrations. Anthropometric data such as height, weight and blood pressure were measured. The study participants were closely followed and alerted deep in the dry season for the second data collection as the baseline.Results: This study recruited more males (58.82%) than females (41.15%) , majority (52.92%) of which were aged 25-29 years with the youngest being 22 years and the elders being 35 years. The study found body mass index (p<0.001), systolic blood pressure (p=0.019), creatinine (p<0.001), urea (p=0.013) and eGFR (p<0.001) to be significantly influenced by climate change. Stage 1 hypertension was predominant among the study participants during the dry season, 8 (15.69%) than was observed during the rainy season, 4 (7.84%) nonetheless the number of participants with normal BMI rose from 49.02% in the rainy season to 62.75% during the dry reason. Additionally, the study observed that the impact of climate change on systolic blood pressure and urea varied based on age and sex. Conclusion: This study revealed that climatic changes cause variations in various biochemical parameters which could lead to renal disease. Public health education on climatic changes and its implication including precautionary measures should be done among inhabitants of Wa and its environs to reduce its effect. Additionally, appropriate dietary patterns should also be advised to avoid the development of non-communicable diseases such as hypertension and obesity that are known principal causes of CKD.