The impact of culturable bacterial community on histopathology in chronic rhinosinusitis

Rom, Darren; Snidvongs, Kornkiat; Sacks, Peta Lee; Dalgorf, Dustin; Pratt, Eleanor; Earls, Peter; Sacks, Raymond; Harvey, Richard J.

doi:10.1002/alr.21220

Cited by 11 publications

(17 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(11) . Investigation into the impact of other hypothesised associations including bacterial culture on inflammatory subtype was not demonstrated on a similar cohort of patients in a prior study (13) , whereas the effect genotype of bacterial growth was in this investigation.…”

Section: Non-taster (Avi/avi) P Valuecontrasting

confidence: 58%

“…A meta-analysis conducted by Thanasumpun et al reported a culture rate of 63.7% in CRS patients, while 47% of CRS patients from a similar cohort cultured a pathogen (13,18) . Furthermore, the cultured bacteria in this study did not represent an acute or invasive infection in any cases and thus deemed colonised rather than infected by the investigators.…”

Section: Non-taster (Avi/avi) P Valuementioning

confidence: 99%

See 1 more Smart Citation

The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis

Rom¹,

Christensen²,

Alvarado³

et al. 2017

Rhin

View full text Add to dashboard Cite

show abstract

Section: Non-taster (Avi/avi) P Valuecontrasting

confidence: 58%

Section: Non-taster (Avi/avi) P Valuementioning

confidence: 99%

The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis

Rom¹,

Christensen²,

Alvarado³

et al. 2017

Rhin

View full text Add to dashboard Cite

show abstract

“…Accordingly, our literature review revealed that the different studies used a diversity of sampling methods (swabs, aspiration, molecular techniques) and sampling sites (middle meatus, maxillary sinus, other ethmoidal bulla, and frontal sinus), but none identified a distinct pattern of bacterial growth or a specific culprit species. The results of the most recent publications are summarized in table 1 [11,12,13,14,15,27,28,29]. …”

Section: Discussionmentioning

confidence: 99%

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

Stern

Hadar²,

Nachalon³

et al. 2016

ORL

View full text Add to dashboard Cite

There are only limited data in the literature, and none specifically from the Middle East, on the pathogenic bacteria in chronic rhinosinusitis (CRS) as opposed to healthy nasal cavities and their association with disease severity. The present study was conducted in the department of head and neck surgery of a tertiary medical center. Middle meatal swabs were taken preoperatively from patients with CRS with nasal polyposis (CRSwNP) (n = 60), CRS without nasal polyposis (CRSsNP) (n = 50), and control patients with septal deviation (n = 26) or no nasal abnormalities (n = 27). Culture findings were compared among the groups and correlated with CRS severity. Positive pathogenic culture rates were 78% in the CRSwNP group and 64% in the CRSsNP group. Twenty pathogenic bacterial species were identified; the most common was Staphylococcus aureus (27%). The most common Gram-negative isolate was Citrobacter spp. (17%). Gram-negative species were significantly more prevalent in the CRSwNP group than the others. Mean Lund-Mackay scores were 12.8 in the CRSwNP group and 6.9 in the CRSsNP group, and were unrelated to the culture findings. Positive culture rates were significantly higher in the septal deviation (54%) than the nasal healthy group (26%), although both values were significantly lower than in the CRS groups. In conclusion, patients with CRS have higher rates of bacterial isolates than patients without CRS. CRSwNP is associated with more Gram-negative bacteria than CRSsNP, regardless of disease severity. The relatively high positive culture rate in patients with septal deviation merits investigation.

show abstract

“…In general, a culturable pathogen in tissue samples was a good predictor of subepithelial fibrosis, Gram-negative bacteria having the strongest association. No significant associations have been established with other clinical outcomes [37].…”

Section: Metalloproteinasesmentioning

confidence: 96%

Remodeling and Repair in Rhinosinusitis

Watelet

Dogné

Mullier

2015

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Remodeling refers to the development of specific but potentially irreversible structural changes in tissue. Caucasian eosinophilic chronic rhinosinusitis (CRS) with polyps associated or not with cystic fibrosis was discriminated by edema from CRS without nasal polyps, characterized by extensive fibrotic fields. However, changes in epithelial and extracellular matrix structures are common findings in all types of chronic inflammatory diseases of upper airways, but rarely specific and highly variable in extend. Recent studies have shown that remodeling in CRS appears to occur in parallel, rather than purely subsequent to inflammation. Furthermore, some preferential remodeling associations can be recognized. Tremendous efforts have been put in research on coagulation factors, cytokines, growth factors, and proteases supporting all phases of upper airway remodeling. The current exploration of other CRS sub-groups and of the particular link with concomitant asthma aims to optimize the classification of CRS and its staging modes and to develop novel therapies.

show abstract

The impact of culturable bacterial community on histopathology in chronic rhinosinusitis

Cited by 11 publications

References 11 publications

The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis

The impact of bitter taste receptor genetics on culturable bacteria in chronic rhinosinusitis

Bacteriology of the Middle Meatus in Chronic Rhinosinusitis with and without Polyposis

Remodeling and Repair in Rhinosinusitis

Contact Info

Product

Resources

About