The impact of co-treatment with graphene oxide and metal mixture on Salmo trutta at early development stages: The sorption capacity and potential toxicity

Jurgelėnė, Živilė; Montvydienė, Danguolė; Šemčuk, Sergej; Stankevičiūtė, Milda; Sauliutė, Gintarė; Pažusienė, Janina; Morkvėnas, Augustas; Butrimienė, Renata; Jokšas, Kęstutis; Pakštas, Vidas; Kazlauskienė, Nijolė; Karabanovas, Vitalijus

doi:10.1016/j.scitotenv.2022.156525

Cited by 9 publications

(7 citation statements)

References 89 publications

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“…With the increasing application of GO, its toxicity has been widely discussed. 48 Balanced tradeoffs between the positive therapeutic effects of GO and the side effects associated with its toxicity should always be noted. Previous research analyzed the cell proliferation among different concentrations of GO within GO-Gel scaffolds, and results showed that low-concentration GO-Gel scaffold (0.25%) was better biocompatible.…”

Section: Discussionmentioning

confidence: 99%

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Qian¹,

Shen²,

Wang³

et al. 2023

IJN

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Purpose We aimed to develop an antioxidant dressing material with pro-angiogenic potential that could promote wound healing. Gelatin (Gel) was selected to improve the biocompatibility of the scaffolds, while graphene oxide (GO) was added to enhance their mechanical property. The loaded N-Acetyl cysteine (NAC) was performing the effect of scavenging reactive oxygen species (ROS) at the wound site. Materials and Methods The physicochemical and mechanical properties, NAC releases, and biocompatibility of the NAC-GO-Gel scaffolds were evaluated in vitro. The regeneration capability of the scaffolds was systemically investigated in vivo using the excisional wound-splinting model in mice. Results The NAC-GO-Gel scaffold had a stronger mechanical property and sustainer NAC release ability than the single Gel scaffold, which resulted in a better capacity for cell proliferation and migration. Mice wound-splinting models revealed that the NAC-GO-Gel scaffold effectively accelerated wound healing, promoted re-epithelialization, enhanced neovascularization, and reduced scar formation. Conclusion The NAC-GO-Gel scaffold not only promotes wound healing but also reduces scar formation, showing a great potential application for the repair of skin defects.

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Section: Discussionmentioning

confidence: 99%

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Qian¹,

Shen²,

Wang³

et al. 2023

IJN

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“…It is urgent that a way to break the trade-off effect is found. (4) Potential toxicity of GO: Several groups [ 114 , 115 , 116 ] reported that even trace doses of GO might also reach the aquatic environment, accumulate, and thus affect biota interactions, which leads to bioaccumulation and acute toxicity in the liver. If GOMs are widely used in desalination, it is reasonably speculated that unstable GOMs would result in residual traces of GO in water under cross-flow scouring with high pressure or temperature.…”

Section: Discussionmentioning

confidence: 99%

GO-Based Membranes for Desalination

Huo

Gao

et al. 2023

Membranes

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Graphene oxide (GO), owing to its atomic thickness and tunable physicochemical properties, exhibits fascinating properties in membrane separation fields, especially in water treatment applications (due to unimpeded permeation of water through graphene-based membranes). Particularly, GO-based membranes used for desalination via pervaporation or nanofiltration have been widely investigated with respect to membrane design and preparation. However, the precise construction of transport pathways, facile fabrication of large-area GO-based membranes (GOMs), and robust stability in desalination applications are the main challenges restricting the industrial application of GOMs. This review summarizes the challenges and recent research and development of GOMs with respect to preparation methods, the regulation of GOM mass transfer pathways, desalination performance, and mass transport mechanisms. The review aims to provide an overview of the precise regulation methods of the horizontal and longitudinal mass transfer channels of GOMs, including GO reduction, interlayer cross-linking, intercalation with cations, polymers, or inorganic particles, etc., to clarify the relationship between the microstructure and desalination performance, which may provide some new insight regarding the structural design of high-performance GOMs. Based on the above analysis, the future and development of GOMs are proposed.

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“…Will transformations or potential degradation of 2-D nanomaterial in the nanocomposite containing AgNPs promote the release of AgNPs and their transformations? Exposure of fish larvae Salmo trutta to graphene oxide with a mixture of heavy metals Cr, Cu, Ni, and Zn resulted in strong sorption of the metals to the GO surface, a decrease in metal accumulation, and mitigation of the metal toxicity [ 250 ]. On the other hand, the opposite response was observed in zebrafish larvae after their co-exposure to GO and Cr 6+ , which caused a modification in the GO surface morphology and structure and enhanced toxicity [ 251 ].…”

Section: Factors Affecting Toxicitymentioning

confidence: 99%

Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

et al. 2022

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Biosensors often combine biological recognition elements with nanomaterials of varying compositions and dimensions to facilitate or enhance the operating mechanism of the device. While incorporating nanomaterials is beneficial to developing high-performance biosensors, at the stages of scale-up and disposal, it may lead to the unmanaged release of toxic nanomaterials. Here we attempt to foster connections between the domains of biosensors development and human and environmental toxicology to encourage a holistic approach to the development and scale-up of biosensors. We begin by exploring the toxicity of nanomaterials commonly used in biosensor design. From our analysis, we introduce five factors with a role in nanotoxicity that should be considered at the biosensor development stages to better manage toxicity. Finally, we contextualize the discussion by presenting the relevant stages and routes of exposure in the biosensor life cycle. Our review found little consensus on how the factors presented govern nanomaterial toxicity, especially in composite and alloyed nanomaterials. To bridge the current gap in understanding and mitigate the risks of uncontrolled nanomaterial release, we advocate for greater collaboration through a precautionary One Health approach to future development and a movement towards a circular approach to biosensor use and disposal.

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The impact of co-treatment with graphene oxide and metal mixture on Salmo trutta at early development stages: The sorption capacity and potential toxicity

Cited by 9 publications

References 89 publications

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

Graphene Oxide/Gelatin Nanofibrous Scaffolds Loaded with N-Acetyl Cysteine for Promoting Wound Healing

GO-Based Membranes for Desalination

Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors

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