The Impact of Body-Weight Components on Forced Spirometry in Healthy Italians

Abstract

Many studies have investigated lung function in relation to age and height among Caucasians, however, most of these studies did not consider the individual components of body weight. The objective of the present study was to study the effect of body weight components [bone-free lean body mass (BF-LBM), bone mineral content (BMC), and fat mass (FM)] measured by dual x-ray absorptiometry (DXA) on the lung-function variables (FVC, FEV1, and PEF) and to derive prediction equations for these variables in healthy adult Italians. Dynamic spirometric tests and body composition analysis by DXA were performed on 58 nonsmoking males, mean age ( +/-SE) 26.72 +/- 1.98 years and BMI 25.51 +/- 0.64 kg/m2, and 60 nonsmoking females matched for age and BMI (29.61 +/- 1.65 years and 26.45 +/- 1.05 kg/m2, respectively). Bivariate linear regression analysis showed the variables age, height, BF-LBM, BMC, and the interaction term BF-LBM*Height, but not weight and FM, to correlate significantly with lung-function variables for males and for females separately. Multiple linear regression analysis showed that sex, age, height, and BF-LBM*Height were significantly associated with FVC, FEV1, and PEF. The prediction equations developed for FVC, FEV1, and PEF on the basis of the independent variables i.e. sex, age (y), height (m), and BF-LBM*Height (kg. m) had a significantly higher cumulative correlation coefficient and a lower SEE compared with those based on age and height only. The present report suggests that the BF-LBM, expressed independently from height, can be considered for predicting lung-function variables.

Avaliação da função pulmonar na obesidade graus I e II

“…Various studies have shown altered pulmonary function in individuals with class III obesity. However, there have been few studies involving obese individuals with lower BMI (29,31,33) . In 1978, Schoenberg et al (29) reported that, due to the related increase in muscle strength, pulmonary function initially increases in parallel with weight gain, although subsequent impairment of chest wall mobility results in reduced pulmonary function.…”

Relationship between body composition and lung function in elderly men and women

“…23 The largest FVC and FEV 1 values were recorded after examining the data from all the acceptable curves, even if they did not come from the same curve. [24][25][26] …”

Spirometric reference values for children and adolescents from Kazakhstan

“…The spirometric parameters most commonly employed are forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1). The prediction of FVC and FEV1 from equations based on gender, age and height is commonly employed to obtain reference values for evaluating lung function (Parma et al 1996;Coultas et al 1998;Mohamed et al 2002). Other anthropometric parameters such as body mass index (BMI) may slightly improve the accuracy of the prediction (Marcus et al 1988).…”