The Impact of Body Mass Index on Right Ventricular Systolic Functions in Normal and Mildly Obese Healthy Patients: A Velocity Vector Imaging Study

Yıldırımtürk, Özlem; Tayyareci, Yelda; Aytekin, Saide

doi:10.1111/j.1540-8175.2011.01422.x

Cited by 12 publications

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References 36 publications

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“…In contrast to the above mentioned results, we and others 17,25,26) have found no association of RV function and increasing BMI in obese and/or overweight persons. Additionally, right atrial and right ventricular end-systolic and diastolic dimensions, as well as RV diastolic function did not differ significantly across increasing BMI categories.…”

Section: Discussioncontrasting

confidence: 42%

“…Additionally, right atrial and right ventricular end-systolic and diastolic dimensions, as well as RV diastolic function did not differ significantly across increasing BMI categories. 17,25,26) On the other hand, these studies consistently found significant alterations of LV parameters, implying more sensible adaptions of the left than the right heart to increasing adiposity. The reasons for the incongruent study results remain speculative.…”

Section: Discussionmentioning

confidence: 86%

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Relation Between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function

et al. 2016

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SummaryThis study sought to examine the relationships between right ventricular (RV) function and geometry, morbid obesity with and without the metabolic syndrome, and the effect of long-term weight loss. Obese (n = 153, BMI 41.2 ± 8.7 kg/m 2 ) and healthy non-obese control subjects (n = 38, BMI 25.5 ± 3.3 kg/m 2 ) of similar age and gender distribution were prospectively studied during the course of a 1-year weight reduction program with echocardiography at baseline and after one year of follow up. Function and geometry of the right heart were evaluated by tricuspid annular plane systolic excursion (TAPSE), tricuspid annular systolic velocity (TDI S'), RV myocardial performance index (TEI), RV end-diastolic (RVEDD) and end-systolic diameter (RVESD), area of the right atrium (RAA), and systolic pulmonary artery pressure (PAP). Whereas parameters of systolic and diastolic LV function were significantly worse in the obese subjects than those in the non-obese subjects (EF 66 ± 6 versus 69 ± 6%, P = 0.004; E/E' 7.4 ± 2.5 versus 6.3 ± 2.6, P = 0.010), parameters of RV function (TAPSE 25.6 ± 4.5 versus 25.1 ± 3.5 mm, P = 0.528; TDI S' 13.5 ± 2.9 versus 13.8 ± 2.9 mm/second, P = 0.553; TEI 0.25 ± 0.13 versus 0.28 ± 0.09, P = 0.283) as well as geometry measurements were comparable between the obese and non-obese participants and also in obese subjects with full blown metabolic syndrome. Additionally, successful weight reduction did not alter the RV parameters. Nevertheless, in the few obese subjects with RV dysfunction (n = 7), metabolic syndrome parameters were more pronounced than in obese with normal RV function.Morbid obesity with and without the metabolic syndrome is accompanied by an impaired LV systolic and diastolic function. In contrast, RV function appears to be less affected by obesity independent of the presence of the metabolic syndrome. (Int Heart J 2016; 57: 441-448) Key words: Adiposity, Heart failure, Echocardiography O besity and the metabolic syndrome are fast-growing disorders in western countries which are associated with variant cardiovascular abnormalities leading to a high risk of cardiovascular morbidity and mortality.1) The Framingham Heart Study demonstrated a 2-fold higher risk of developing heart failure in obese subjects with a body mass index ≥ 30 kg/m 2 in comparison to non-obese ones in a large community-based sample.2) Moreover, adiposity was described as an independent risk factor for developing heart failure with a population attributable risk of 8.0% in a large prospective cohort study with a follow-up of 19 years. 3)Adiposity results in different subclinical changes in cardiac function.1) Arterial hypertension, impaired glucose tolerance, dyslipidemia, altered hemodynamics, elevation of neurohumoral and inflammatory markers, prothrombotic state, and obstructive sleep apnea are associated conditions which may further predispose to heart failure. [2][3][4] While the influence of obesity on left ventricular (LV) function is understood in more detail, such as the correlation of body ...

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Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 86%

Relation Between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function

et al. 2016

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“…Childhood obesity is one of the most serious public health problems (1)(2)(3). Obesity and cardiac involvement has been reported frequently in the literature, but analysis of regional myocardial function in children by two-dimensional (2D) speckle tracking echocardiography (STE) is rarely documented (4)(5)(6)(7)(8).…”

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confidence: 99%

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

et al. 2015

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Background: Impaired subclinical ventricular function may contribute to the risk of cardiovascular disease in obesity. Aims: The aim of this study was to determine the influence of obesity on left ventricular (LV) longitudinal myocardial function in normotensive obese children using two-dimensional (2D) speckle tracking echocardiography (STE). Study Design: Case-control study. Methods: Sixty normotensive obese children aged 10-16 years (mean age, 13.9±2.3 years) were compared with 50 normal-weight controls. Obese participants had a body mass index (BMI)≥95 th percentile. Regional strain/strain rate (SR) values were compared with left ventricular (LV) parameters. The correlation was studied by linear regression analysis. Results: Obese subjects exhibited a significantly higher LV end-diastolic diameter, left atrium/aortic diameter ratio, and LV mass/index when compared to controls (p<0.001). Left ventricular ejection fraction and regional systolic myocardial velocities were similar in the obese and control groups. By 2D STE, regional strain of both the septal wall (average strain:

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“…Também se tem demonstrado que a infiltração gordurosa do miocárdio repercute não só na estrutura, mas também na mecânica ventricular [11][12][13][14] . Esse aumento no volume circulante foi corroborado no presente estudo com uma associação direta estatisticamente significativa entre o débito cardíaco, o volume de ejeção e o índice de massa corpórea, identificando-se um valor máximo quando o índice de massa chega a 35 e 37 kg/m No estudo do impacto do índice de massa corpórea sobre a disfunção diastólica do ventrículo esquerdo, Cil e cols.…”

Section: Discussionunclassified

“…As variáveis para a avaliação da função sistólica e diastólica do ventrículo direito não mostraram mudanças relevantes relacionadas com o índice de massa corpórea, resultados coerentes com a literatura, na qual se descreve que a função do ventrículo direito não se vê afetada pelo sobrepeso, nem a obesidade 12,18 . 8 demonstraram que a normalização da massa ventricular esquerda pela área de superfície corpórea e pelo comprimento introduz artefatos relacionados com a indexação da massa ventricular à massa corpórea e erros na estimativa do impacto do sobrepeso.…”

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Relationship of Body Mass Index with Changes in Cardiac Geometry and Function in 5,898 Patients Evaluated by Transthoracic Echocardiography

Rubio¹,

Molina²,

Anaya³

et al. 2015

Arquivos Brasileiros De Cardiologia - Imagem Cardiovascular

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ResumoIntrodução: Este estudo descreve a relação entre índice de massa corpórea (IMC) e a geometria e função cardíaca analisada por ecocardiografia transtorácica. O aumento do IMC teve uma associação direta estatisticamente significativa com a massa ventricular esquerda, observando-se inicialmente hipertrofia concêntrica leve, que se faz excêntrica na medida em que aumenta, especialmente quando se normaliza pela relação alométrica (altura 2,7 ). Também observou-se aumento do volume de ejeção e do débito cardíaco e evidenciou-se associação inversa entre o índice de massa corpórea e a relação E/A de enchimento mitral, com diminuição sigificativa da velocidade de e' do Doppler tecidual, demonstrando-se disfunção diastólica do tipo alteração do relaxamento do ventrículo esquerdo no indivíduo com sobrepeso ou obeso. Observou-se aumento discreto, porém significativo, da área e do volume indexado do átrio esquerdo para a massa corpórea. Não houve diferenças na geometria e função do ventrículo direito. Conclusões AbstractIntroduction: This study describes the relationship between Body Mass Index (BMI) and the cardiac geometry and heart function assessed by transthoracic echocardiography.

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The Impact of Body Mass Index on Right Ventricular Systolic Functions in Normal and Mildly Obese Healthy Patients: A Velocity Vector Imaging Study

Abstract: The results of our study show no changes in the RV functions in obese and overweight who were otherwise healthy subjects. We also revealed a significant correlation between BMI and left ventricular diameters and wall thickness but no relation with RV diameters or functions.

Cited by 12 publications

References 36 publications

Relation Between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function

Relation Between Obesity, Metabolic Syndrome, Successful Long-Term Weight Reduction, and Right Ventricular Function

Effect of Obesity on Left Ventricular Longitudinal Myocardial Strain by Speckle Tracking Echocardiography in Children and Adolescents

Relationship of Body Mass Index with Changes in Cardiac Geometry and Function in 5,898 Patients Evaluated by Transthoracic Echocardiography

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