2002
DOI: 10.1007/s00415-002-0733-1
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The impact of blepharospasm and cervical dystonia on health-related quality of life and depression

Abstract: The aim of the study was to evaluate and compare health-related quality of life (HR-QoL) and depression in essential blepharospasm (BSP) and idiopathic cervical dystonia (CD), to identify the clinical and demographic factors associated with poor HR-QoL in both disorders and to analyse the effect of Botulinum Toxin A (BtxA) therapy. Two hundred-twenty consecutive patients with BSP (N = 89, 62 % women, mean age 64 years, mean disease duration 7 years) and CD (N = 131, 64 % women, mean age 53 years, mean disease … Show more

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Cited by 174 publications
(201 citation statements)
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“…Muller et al. (2002) found depression of some BSP and CD patients did not improve correspondingly after significant relief of motor symptom and pain by botulinum toxin A treatment, which supported our findings that no significant correlation was found between depression and motor severity. The observation that more than half of CD patients developed depression before the onset of motor symptom (Wenzel et al., 1998), challenged the traditional view that mood disorders were secondary to motor disability in dystonia.…”
Section: Discussionsupporting
confidence: 83%
“…Muller et al. (2002) found depression of some BSP and CD patients did not improve correspondingly after significant relief of motor symptom and pain by botulinum toxin A treatment, which supported our findings that no significant correlation was found between depression and motor severity. The observation that more than half of CD patients developed depression before the onset of motor symptom (Wenzel et al., 1998), challenged the traditional view that mood disorders were secondary to motor disability in dystonia.…”
Section: Discussionsupporting
confidence: 83%
“…Even as a generic measure of health status widely adopted to assess QoL 8 , the SF-36 has not been used in this study, since it has undergone a considerable amount of reliability tests and validity studies, proving to be impaired in patients with craniocervical dystonia 9 . The 24 questions of the CDQ-24 are divided in five areas: stigma (6), emotional wellbeing (5), pain (3), activities of daily living (6) and family/social life (4). Each question has five possible answers, in which 0 (zero) is the best and 4 is the worst.…”
Section: Methodsmentioning
confidence: 99%
“…Although different studies 4,5,6 have evaluated the impact on the QoL of patients with cervical dystonia, few use a specific scale for the disease.…”
mentioning
confidence: 99%
“…2,3 With time, the phenomenon becomes more frequent until it causes difficulty with carrying out daily activities, and impairs health-related quality of life, causing social embarrassment, anxiety, and depression. [3][4][5] Rarely the spasm can cause functional blindness. 5 A variety of treatments are available for facial dystonias: treatment of dry eye symptoms, referral to patient groups, 3 treatment with drugs including antidepressants, anxiolytics, anticonvulsants, anti-Parkinson drugs, and muscle relaxants, 6 and surgery including facial nerve avulsion, 7 orbicularis oculi myectomy, [8][9][10] and brow suspension.…”
Section: Introductionmentioning
confidence: 99%