The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests

Netanel, Carmit; Goitein, David; Rubin, Moshe; Kleinbaum, Yeruham; Katsherginsky, Sima; Hermon, Hila; Tsaraf, Keren; Tachlytski, I.; Herman, Amir; Safran, Michal; Ben‐Ari, Ziv

doi:10.1016/j.amjsurg.2020.11.045

Cited by 14 publications

(13 citation statements)

References 24 publications

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“…A flowchart summarizing the stages of identification, screening, eligibility and inclusion of studies, prepared according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses (PRISMA) guidelines, 9 is presented in Figure 1. Twenty‐four articles were included in the systematic review, 10–33 and 22 of them were finally included in the meta‐analysis 11–17,19–33 …”

Section: Resultsmentioning

confidence: 99%

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Circulating adiponectin in patients with nonalcoholic fatty liver disease‐related liver fibrosis: A systematic review and a meta‐analysis

Tontikidou

Makri

Evripidou

et al. 2022

J of Gastro and Hepatol

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Background and Aim: There are conflicting data on adiponectin concentrations in nonalcoholic fatty liver disease (NAFLD). The main aim was to compare circulating total adiponectin concentrations in NAFLD patients with versus without liver fibrosis. Methods: A systematic search was performed in PubMed, Scopus, and Cochrane Library. Twenty-two studies comprising 1753 biopsy-proven NAFLD individuals (1290 with and 463 without fibrosis) were included in the meta-analysis. Results: There was no difference in adiponectin concentration between NAFLD patients with versus without fibrosis (standardized mean difference [SMD]: À0.15; 95% confidence interval [95% CI]: À0.35 to 0.05). Heterogeneity was moderate among studies (Ι 2 : 60%, P < 0.001); no risk of publication bias was observed (Egger's test; P = 0.37). The sensitivity analysis, performed after the exclusion of studies with (i) children/adolescents and morbidly obese patients (n = 3) and (ii) adiponectin measurement with other methods than enzyme-linked immunosorbent assay (ELISA) (n = 9), revealed significantly lower adiponectin concentrations in NAFLD patients with fibrosis (i) SMD: À0.23, 95% CI: À0.41 to À0.04; (ii) SMD: -0.30, 95% CI: À0.55 to À0.04, respectively). Meta-regression analysis revealed no significant association of adiponectin SMD with age, alanine aminotransferase, aspartate aminotransferase, γ-glutamyl-transferase, homeostasis model assessment insulin resistance and the proportion of men. Conclusions: Overall, patients with NAFLD and fibrosis had similar adiponectin concentrations with patients with NAFLD without fibrosis. However, adiponectin concentration was lower in NAFLD patients with fibrosis than those without fibrosis within the adult patients without morbid obesity and in studies in which adiponectin was measured with the same method (ELISA).

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Section: Resultsmentioning

confidence: 99%

“…The 24 studies included in the systematic review were published between 2005 and 2021 and reported data on 1808 individuals (1312 NAFLD patients with fibrosis F1–F4, 463 NAFLD patients without fibrosis, and 33 biopsy‐proven non‐NAFLD controls) 10–33 . The main characteristics of these studies are presented in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Circulating adiponectin in patients with nonalcoholic fatty liver disease‐related liver fibrosis: A systematic review and a meta‐analysis

Tontikidou

Makri

Evripidou

et al. 2022

J of Gastro and Hepatol

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“…After 1,462 articles were excluded based on study title and abstract, 136 articles were selected for full text review, of which 31 articles met the final inclusion criteria (Figure 2). In total, five articles originated from the United States (36)(37)(38)(39)(40), six from Brazil (41)(42)(43)(44)(45)(46), four from France (18,(47)(48)(49), two from Poland (50,51), Australia (52,53) and Japan (54,55) respectively and one each from Denmark (56), Canada (57), Germany (58), Greece (59), India (60), Israel (61), Netherlands (62), Saudi Arabia (63), Taiwan (64) and Turkey (65). Of the 31 included articles, there were 20 single-arm and 11 doublearm studies.…”

Section: Summary Of Included Articlesmentioning

confidence: 99%

Foregut bypass vs. restrictive bariatric procedures for nonalcoholic fatty liver disease: a meta-analysis of 3,355 individuals

Lim¹,

Lin²,

Ng³

et al. 2023

Hepatobiliary Surg Nutr

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Background: Bariatric surgery represents an important treatment option for severely obese patients with nonalcoholic fatty liver disease (NAFLD). However, there remains inadequate data regarding the effects of different bariatric procedures on various NAFLD parameters, especially for histological outcomes. Thus, this meta-analysis aimed to compare the effects of restrictive bariatric procedures and foregut bypass on the metabolic, biochemical, and histological parameters for patients with NAFLD.Methods: Medline and Embase were searched for articles relating to bariatric procedures and NAFLD.Pairwise meta-analysis was conducted to compare efficacy of bariatric procedures pre-vs. post-procedure with subgroup analysis to further compare restrictive against foregut bypass procedures.Results: Thirty-one articles involving 3,355 patients who underwent restrictive bariatric procedures (n=1,460) and foregut bypass (n=1,895) were included. Both foregut bypass (P<0.01) and restrictive procedures (P=0.03) significantly increased odds of fibrosis resolution. Compared to restrictive procedures, foregut bypass resulted in a borderline non-significant decrease in fibrosis score (P=0.06) and significantly lower steatosis score (P<0.001). For metabolic parameters, foregut bypass significantly lowered body mass index (P=0.003) and low-density lipoprotein (P=0.008) compared to restrictive procedures. No significant differences were observed between both procedures for aspartate aminotransferase (P=0.17) and alkaline phosphatase (P=0.61). However, foregut bypass resulted in significantly lower gamma-glutamyl transferase than restrictive procedures (P=0.01) while restrictive procedures resulted in significantly lower alanine transaminase than foregut bypass (P=0.02).

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“…erefore, the prevention and treatment of NAFLD can be achieved by maintaining a healthy diet. For example, studies have shown that there is a positive correlation between the intake of foods rich in cholesterol, saturated fatty acids, or high fructose and the prevalence of NAFLD, such as sugary soft drinks and red meat [7,8]. On the contrary, there was a negative correlation between n-3 polyunsaturated fatty acids and the prevalence of NAFLD.…”

Section: Introductionmentioning

confidence: 99%

Association between Dietary Pattern, Nutritional Status, Metabolic Factors, and Nonalcoholic Fatty Liver Disease

Xing

Huang

Liu

2022

Contrast Media & Molecular Imaging

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Nonalcoholic fatty liver disease (NAFLD) can be harmful to the body to varying degrees, and over a prolonged period, patients may develop steatotic cirrhosis or even develop liver cancer based on cirrhosis. Moreover, its harms are related to its severity. Patients with severe steatosis develop hepatocyte destruction, transaminase abnormalities, and long-term progression to steatotic cirrhosis, or even liver cancer, which should be treated aggressively. In order to provide theoretical basis for the prevention and early intervention of NAFLD, we analysis the relationship between nonalcoholic fatty liver disease(NAFLD) and dietary pattern, nutritional status, metabolic factor A total of 517 participants (200 males and 317 females) recruited in this study were gained from the health check center of The Ningbo Seventh Hospital, Ningbo, China, from September 2018 to August 2019. Patients diagnosed with NAFLD were selected as the study subjects. The data on the dietary pattern, nutritional status, and metabolic factors were collected for further analysis. A total of 517 eligible participants (317 females and 200 males) were involved in this study, with a mean age of 54.7 ± 16.7 years. Dessert and fruit diet, healthy dietary pattern, animal food dietary pattern, high salt diet mode, triglyceride, uric acid, adiponectin, and waist-hip ratio were significantly different between the two groups ( P < 0.05 ). Dietary patterns, nutritional status, metabolic factors, and NAFLD are correlated. Furthermore, applying this correlation law can better manage NAFLD patients.

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The impact of bariatric surgery on nonalcoholic fatty liver disease as measured using non-invasive tests

Cited by 14 publications

References 24 publications

Circulating adiponectin in patients with nonalcoholic fatty liver disease‐related liver fibrosis: A systematic review and a meta‐analysis

Circulating adiponectin in patients with nonalcoholic fatty liver disease‐related liver fibrosis: A systematic review and a meta‐analysis

Foregut bypass vs. restrictive bariatric procedures for nonalcoholic fatty liver disease: a meta-analysis of 3,355 individuals

Association between Dietary Pattern, Nutritional Status, Metabolic Factors, and Nonalcoholic Fatty Liver Disease

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