The Impact of Alkaloids Structures from NaturalCompounds on Public Health

Cadar, Emin; Tomescu, Aneta; Erimia, Cristina Luiza; Mustafa, Alef; Sîrbu, Rodica

doi:10.26417/ejser.v5i1.p34-39

Cited by 7 publications

(4 citation statements)

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“…Several mechanisms are involved in the defense of the gastrointestinal tissue by alkaloids, and it revealed common peculiarities as immunomodulation, increased gastric blood flow and participation of the endogenous antioxidant system [14]. Most alkaloids are crystalline substances, which dissolve poorly in water due to their low solubility grade into aqueous systems of preparation [23]. Our research group studied the antiinflammatory and antinociceptive activity of epiisopiloturine in its crude formulation; however it was possible carry on the alkaloid solubilized only in 2% DMSO [11].…”

Section: Discussionmentioning

confidence: 99%

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

Nicolau

Carvalho

Pacífico

et al. 2017

Biomedicine & Pharmacotherapy

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Section: Discussionmentioning

confidence: 99%

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

Nicolau

Carvalho

Pacífico

et al. 2017

Biomedicine & Pharmacotherapy

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“…As the L. liyuyingi extract has demonstrated significant pain inhibition in both models of peripheral and centrally mediated analgesia, it suggests that the active components of the plant may be able to induce both anti-inflammatory and opioid-like effects to alleviate pain [89,90,135]. Based on the phytochemical screening, Laboni et al (2017) [22] attributed the analgesic effect of the L. liyuyingi leaf extract to its alkaloid content as alkaloids such as morphine, codeine and quinine are known to produce mild to strong analgesic effects [162].…”

Section: Litsea Liyuyingi Liou Homentioning

confidence: 99%

The Analgesic Potential of Litsea Species: A Systematic Review

Goh,

Samsul,

Mohaimin

et al. 2024

Molecules

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Various plant species from the Litsea genus have been claimed to be beneficial for pain relief. The PRISMA approach was adopted to identify studies that reported analgesic properties of plants from the Litsea genus. Out of 450 records returned, 19 primary studies revealed the analgesic potential of nine Litsea species including (1) Litsea cubeba, (2) Litsea elliptibacea, (3) Litsea japonica, (4) Litsea glutinosa, (5) Litsea glaucescens, (6) Litsea guatemalensis, (7) Litsea lancifolia, (8) Litsea liyuyingi and (9) Litsea monopetala. Six of the species, 1, 3, 4, 7, 8 and 9, demonstrated peripheral antinociceptive properties as they inhibited acetic-acid-induced writhing in animal models. Species 1, 3, 4, 8 and 9 further showed effects via the central analgesic route at the spinal level by increasing the latencies of heat stimulated-nocifensive responses in the tail flick assay. The hot plate assay also revealed the efficacies of 4 and 9 at the supraspinal level. Species 6 was reported to ameliorate hyperalgesia induced via partial sciatic nerve ligation (PSNL). The antinociceptive effects of 1 and 3 were attributed to the regulatory effects of their bioactive compounds on inflammatory mediators. As for 2 and 5, their analgesic effect may be a result of their activity with the 5-hydroxytryptamine 1A receptor (5-HT1AR) which disrupted the pain-stimulating actions of 5-HT. Antinociceptive activities were documented for various major compounds of the Litsea plants. Overall, the findings suggested Litsea species as good sources of antinociceptive compounds that can be further developed to complement or substitute prescription drugs for pain management.

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“…The alkaloids are nitrogenous compounds that are colorless and odorless, and have a bitter and toxic taste (the toxicity of most plants is due to the presence of alkaloids in them) [27]. Resins are plant materials with a complex chemical composition that result from the oxidation of some essential oils.…”

Section: Turbines and Steroidsmentioning

confidence: 99%

Effect of tannin fruit extracts on Candida albicans yeast

Noman

Suliman

2023

Int J Med Sci

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Background: The results of the chemical detection showed that the active groups in the fruit extracts of the tannin plant contained glycosides, saponins, flavonoids, tannins, terpene and phenols. Aim: To evaluate Tannins inhibition activity against Candida albicans. Materials and methods: A number of aqueous, alcoholic and acetone fruit extracts of Tannins were prepared, and their effect on inhibition of Candida albicans was tested. Four concentrations were used [10, 20, 30, 40 (mg / ml)]. Results: The effect of tested extracts on yeast varied in terms of concentration and type of extract. The inhibition diameter was positively correlated to the increase in extract concentration. The results showed that the acetone extract was with a very high effectiveness and demonstrate higher inhibition effect against C. albicans, with an average inhibition diameter of 15.5 and 20 mm at a concentration of 10 and 20 mg / ml, respectively, while it was increased to reach 24.5 and 28 mm at a concentration 30 and 40 mg/ml, respectively. The alcoholic extract came in the second inhibition effect. Conclusion: The acetone extract shows a higher inhibitory activity than alcoholic and aqueous extracts. The interesting finding of this study was the inhibition against C. albicans was exhibited in the first 24 hours, while the nystatin inhibitory effect started in after 48 hours. The inhibition timing was vital as it lead to short course of treatment and less possibility for resistance induction

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The Impact of Alkaloids Structures from NaturalCompounds on Public Health

Abstract: Abstract

Cited by 7 publications

References 0 publications

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

Epiisopiloturine hydrochloride, an imidazole alkaloid isolated from Pilocarpus microphyllus leaves, protects against naproxen-induced gastrointestinal damage in rats

The Analgesic Potential of Litsea Species: A Systematic Review

Effect of tannin fruit extracts on Candida albicans yeast

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