The Impact of Age on the Demographic, Clinical, Radiographic Characteristics and Treatment Outcomes of Pulmonary Tuberculosis Patients in Taiwan

Wang, C.-S.; Chen, H.-C.; Yang, Chih‐Jen; Wang, W.-Y.; Chong, Inn‐Wen; Hwang, Jhi-Jhu; Huang, Ming‐Shyan

doi:10.1007/s15010-008-7199-8

Cited by 54 publications

(52 citation statements)

References 27 publications

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“…In fact, the drug susceptibility pattern has been shown to vary throughout Taiwan [19]. The reason for the variability may be due to the use of different testing methods between studies [20][21][22][23][24][25][26][27] or to differences in local epidemiology, or both. Therefore, clinicians need to be knowledgeable of the local epidemiology of drug-resistant TB, and laboratories should maintain up-to-date drug susceptibility data on local isolates of MTB.…”

Section: Discussionmentioning

confidence: 99%

Differences in drug resistance profiles of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in a medical centre in Taiwan, 2000–2010

Lai

Liu

Tan

et al. 2011

International Journal of Antimicrobial Agents

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Section: Discussionmentioning

confidence: 99%

Differences in drug resistance profiles of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in a medical centre in Taiwan, 2000–2010

Lai

Liu

Tan

et al. 2011

International Journal of Antimicrobial Agents

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“…We also found that most of the PR occurred in younger age group of 15-34 years. The possible explanation for this could be younger age was predictive for PR because immunologic status has been found to decrease with aging (18). An interesting finding in our study was that all paradoxical responses occurred in the patients with unilateral lymphadenopathy only.…”

Section: Discussionmentioning

confidence: 47%

Pattern and predictors of paradoxical response in patients with peripheral lymph node tuberculosis

Batra¹,

Rajawat

Takhar

et al. 2017

Tuberk Toraks

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Reason behind such response in only selective patients is not clearly understood. We evaluated the pattern and predictors for paradoxical response(s) (PR) in patients with peripheral lymph node tuberculosis (TB). Materials and Methods: Study included patients aged > 6 years with peripheral lymphadenopathy of tubercular etiology attending a tertiary care hospital from Jan 2010 to Dec 2010. PR in our study was defined as worsening of pre-existing disease or development of new lesions in a patient who has been on anti-TB therapy for at least 2 weeks. Results

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“…(4,7,10,11) Although cavitation is the most widely reported chest X-ray finding in patients with PTB, the reported rates range from very low (in studies involving HIV-infected or otherwise immunocompromised patients, children, or the elderly) to very high (in patients with concomitant diabetes). (7,(9)(10)(11)23) Among patients with reactivation tuberculosis, cavitary lesions are reported to occur in 28-82%, the mean being 40-50%. (6,9,11,20,24) Kartaloglu e al.…”

Section: Discussionmentioning

confidence: 99%

“…(2)(3)(4)(5)(6)(7)(8) However, in patients with HIV infection, diabetes, silicosis or malignancy, especially in females and in the elderly, the lower lung fields can be involved. (2,4,7,(9)(10)(11)(12)(13) Although sputum smear and culture are the main tools for the diagnosis and follow-up of PTB, clinicians frequently use chest X-ray in the differential diagnosis and the assessment of treatment responses. The WHO Expert Committee on Tuberculosis Ninth Report, issued in 1974, (14) strongly discouraged the mass screening for tuberculosis through the use of chest X-rays.…”

Section: Introductionmentioning

confidence: 99%

Radiografia torácica e bacteriologia na fase inicial de tratamento de 800 pacientes masculinos com tuberculose pulmonar

et al. 2011

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Objective: To evaluate chest X-rays of patients with pulmonary tuberculosis and to determine whether the extent of radiographic lesions correlates with bacteriological parameters. Methods: In this retrospective, descriptive study, we evaluated chest X-rays, as well as AFB detection by smear microscopy and culture for Mycobacterium tuberculosis, initially and during the first two months of treatment, in 800 male patients hospitalized between 1995 and the present at a 250-bed hospital in northwestern Turkey. Results: The initial mean ESR was 58 ± 37 mm/h. Initial sputum smears and cultures were positive in 83.8% and 89.5% of the patients, respectively. After the first month of treatment, the proportion of patients with positive sputum culture was higher among those with cavitary tuberculosis than among those with non-cavitary tuberculosis (53.7% vs. 37.7%, p < 0.001). The number of affected zones was not correlated with age, symptom duration, contact with an active tuberculosis patient, or concomitant diabetes (p > 0.05 for all) but was positively correlated with the ESR (r = 0.23, p < 0.001). During the first and second months of treatment, conversion to smear-negative status was less common in patients with bilateral involvement than in those with unilateral involvement (p < 0.001 and p = 0.002 for months 1 and 2, respectively). Disease extent did not correlate with age, symptom duration, contact with an active tuberculosis patient, or concomitant diabetes but did correlate with delayed bacteriological recovery. Conclusions: Chest X-ray and bacteriology are valuable tools for the evaluation of pulmonary tuberculosis.Keywords: Radiography, thoracic; Bacteriology; Tuberculosis, pulmonary/drug therapy. ResumoObjetivo: Avaliar radiografias de tórax de pacientes com tuberculose pulmonar e determinar se a extensão das lesões radiográficas correlaciona-se com os parâmetros bacteriológicos. Métodos: Neste estudo descritivo e retrospectivo; foram avaliadas radiografias de tórax, baciloscopias para BAAR e culturas de escarro para Mycobacterium tuberculosis no momento basal e durante os dois primeiros meses de tratamento. A amostra foi composta por 800 pacientes masculinos internados entre 1995 até o presente em um hospital com 250 leitos no noroeste da Turquia. Resultados: A VHS média inicial foi de 58 ± 37 mm/h. Inicialmente, a baciloscopia e as culturas de escarro tiveram resultado positivo em 83,8% e em 89,5% dos pacientes, respectivamente. Após o primeiro mês do tratamento, a proporção de culturas positivas foi maior nos pacientes com doença cavitária do que naqueles sem doença cavitária (53,7% vs. 37,7%; p < 0,001). Não houve correlação do número de zonas afetadas com idade, duração de sintomas, contato com paciente com tuberculose ativa, diabetes concomitante (p > 0.05 para todos), mas houve correlação positiva com VHS (r = 0,23, p < 0,001). Durante o primeiro e o segundo mês de tratamento, a negativação da baciloscopia foi menos frequente nos pacientes com comprometimento bilateral do que naqueles com compr...

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The Impact of Age on the Demographic, Clinical, Radiographic Characteristics and Treatment Outcomes of Pulmonary Tuberculosis Patients in Taiwan

Cited by 54 publications

References 27 publications

Differences in drug resistance profiles of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in a medical centre in Taiwan, 2000–2010

Differences in drug resistance profiles of Mycobacterium tuberculosis isolates causing pulmonary and extrapulmonary tuberculosis in a medical centre in Taiwan, 2000–2010

Pattern and predictors of paradoxical response in patients with peripheral lymph node tuberculosis

Radiografia torácica e bacteriologia na fase inicial de tratamento de 800 pacientes masculinos com tuberculose pulmonar

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