The impact of admission red cell distribution width on the development of poor myocardial perfusion after primary percutaneous intervention

The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

“…In addition, it has been found in previous studies that inflammatory cytokines suppress the maturation of erythrocytes, therefore immature erythrocytes which enter the circulation may accelerate erythropoiesis [20]. Previously, we published first outcomes of this study and demonstrated that there was a good correlation between hs-CRP level, which is an important inflammatory marker and RDW level on admission [21]. Oxidative stress *Adjusted for age, high sensitive C-reactive protein, left anterior descending artery lesion, creatine kinase-MB on admission, heart rate after percutaneous coronary intervention, previously used an angiotensin converting enzyme inhibitor, premature discontinuation of clopidogrel therapy, presence of electrocardiographic no-reflow and angiographic failure in the analysis; HR -hazard ratio; CI -confidence interval; Hb -hemoglobin Figure 2.…”

Predictive impact on mediumterm mortality of hematological parameters in Acute Coronary Syndromes: added value on top of GRACE risk score

“…RDW levels were significantly increased in patients with inadequate ST-segment resolution after primary PCI and baseline levels predicted no-reflow. 20 It was also an independent predictor of 6-month cardiovascular mortality, even after adjustment for multiple confounders including anaemia. 20 The mechanisms by which elevated values of RDW are associated with adverse outcome in patients with cardiovascular disease have yet to be fully clarified but are probably multifactorial.…”

“…20 It was also an independent predictor of 6-month cardiovascular mortality, even after adjustment for multiple confounders including anaemia. 20 The mechanisms by which elevated values of RDW are associated with adverse outcome in patients with cardiovascular disease have yet to be fully clarified but are probably multifactorial. In the context of ACS, we have an increase in inflammatory cytokines, oxidative stress, activation of neurohumoral pathways and adrenergic activation, all implicated in adverse outcome after ACS, and all these mechanisms seem to be involved in bone marrow response and erythroid cell poiesis.…”

Red Cell Distribution Width as a Marker of Preeclampsia Severity

“…However, recent studies have found that it is correlated strongly with heightened systolic and diastolic blood pressure and is a poor prognostic indicator in cardiovascular disorders. [4,5,11] Ozcan et al have attributed the rise of RDW in hypertensive disorders to the increased inflammatory response. [12] By impairment of iron metabolism and disturbance in erythropoiesis, it could also result in the release of excess of reticulocytes and disruption in erythrocyte maturation.…”

“…However, recent evidence has shown that increased levels are also seen in hypertension and other cardiovascular disorders. [4,5] It is also associated with diabetic ketoacidosis, thrombotic disorders, malignancies and hepatorenal diseases. [6,7,8] However, there is limited data on the usefulness of RDW in pregnant population and especially the hypertensive disorders of pregnancy.…”