The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

Işık, Turgay; Kurt, Mustafa; Tanboğa, İbrahim Halil; Ayhan, Erkan; Günaydın, Zeki Yüksel; Kaya, Ahmet; Uyarel, Hüseyin

doi:10.5603/cj.a2015.0080

Cited by 20 publications

(21 citation statements)

References 29 publications

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“…Ghaffari et al reported that an elevated baseline RDW could predict adverse outcomes in patients with STEMI undergoing thrombolytic therapy, during a follow-up period of (7.7 ± 3.2) months [ 19 ]. Isik et al studied the effects of RDW level on long-term prognosis in 96 STEMI patients who underwent primary PCI, and finally found that admission RDW level was an independent predictor of long term Mace [ 20 ]. To our knowledge, the main finding of our study is the first report showing the combined value of RDW and the GRACE score in predicting Mace at 36-month follow-up in patients with STEMI who underwent primary PCI.…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic value of RDW for short-term or long-term cardiovascular events have been demonstrated in STEMI patients [ 20 , 25 ]. In a meta-analysis involving 80216 patients from 22 studies, RDW was a remarkably strong predictor of all-cause mortality (HR = 1.80, 95% CI:1.35–2.41, P < 0.001) and non-fatal adverse events (HR = 1.86, 95% CI:1.50–2.31, P < 0.001), although there was significant heterogeneity in the different studies [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

et al. 2018

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The combined value of RDW and GRACE risk score for cardiovascular prognosis in ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has not been fully investigated. This study was designed to explore the combined value of RDW and GRACE risk score on predicting long-term major adverse cardiac event (Mace) in STEMI patients undergoing primary PCI. This study included 390 STEMI patients. The primary endpoint at the (33.5 ± 7.1) months follow-up was composed of cardiac death and nonfatal myocardial infarction. The relationship between clinical parameters and clinical outcomes was evaluated using Cox regression model and receiver operating characteristic (ROC) analysis. Mace occurred in 126 (32.3%) patients including 54 (13.8%) cardiac deaths and 72 (18.5%) nonfatal myocardial infarctions. Patients in Mace group had significantly higher RDW and GRACE score than the patients in non-Mace group. According to the Cox model, RDW and GRACE score were the most important independent predictors of Mace and cardiac death. The best cut-off value for RDW to predict the occurrence of primary events was 13.25% (AUC = 0.694, 95% CI:0.639–0.750, P < 0.001) and that for GRACE score was 119.5 (AUC = 0.721, 95% CI:0.666–0.777, P < 0.001). The combination of RDW and GRACE score were more valuable (AUC = 0.775, 95% CI: 0.727–0.824, P < 0.001). Kaplan–Meier analysis provided significant prognostic information with the highest risk for cardiac death (Log-Rank χ2 = 24.684, P < 0.001) in group with both high RDW (> 13.25%) and high GRACE score (> 119.5). The combination of RDW level and GRACE score may be valuable and simple independent predictors of Mace and cardiac death in STEMI patients undergoing primary PCI. They may be useful tools for risk stratification and may indicate long-term clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

et al. 2018

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“…In another large population study, including as many as 1,760 coronary angiography patients, Gijsberts et al (22) reported that each one standard deviation (SD) increase of RDW was associated with a 19% higher risk of MACE in multivariable, fully adjusted analysis (HR, 1.19; 95% CI; 1.08-1.32; P<0.001). The relationship between RDW and 4-year cardiovascular events after PCI was also investigated in 96 consecutive patients with ACS by Isik et al (23), who finally reported that an increased RDW value was an independent predictor of long-term MACE (HR 5.26; 95% CI, 1.71-16.10; P=0.004). More recently, Ghaffari et al studied 312 patients undergoing thrombolysis for ACS (24), and reported that RDW was an independent predictor of in-hospital occurrence of MACE (RR, 3.17; 95% CI, 1.23-8.46; P=0.017).…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width independently predicts medium-term mortality and major adverse cardiac events after an acute coronary syndrome

et al. 2016

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“…-Eight studies identified as Cohort (including two identified as a retrospective cohort and five identified as a prospective cohort) [20][21][22][23][24][25][26][27].…”

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confidence: 99%

Major Adverse Cardiovascular Events: An Inevitable Outcome of ST-elevation myocardial infarction? A Literature Review

Poudel¹,

Tejpal²,

Rashid³

et al. 2019

Cureus

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Major adverse cardiovascular events (MACE) remain the major cause of mortality and morbidity in patients with STEMI (ST-elevation myocardial infarction). The current literature is aimed to analyze the occurrence of MACE following STEMI irrespective of treatment provided, and follow up after the first diagnosis of STEMI. A PubMed search for Studies of STEMI identified 24,244 articles. After applying our inclusion/exclusion criteria, we found out 75 articles of relevance wherein MACE and its components were considered to be the primary endpoint. These 75 articles included eight Cohort Studies, 13 clinical trials including five randomized controlled trials (RCT), one case-control Study, one cross-sectional study, one review article, and 51 other observational studies. Our analysis shows that MACE remains one of the strongest adverse outcomes among STEMI patients. The current literature review found out the incidence of MACE was 4.2 % to 51% irrespective of the mode of treatment, and follow-ups lasting up to 10 years from the time of STEMI diagnosis.

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The impact of admission red cell distribution width on long-term cardiovascular events after primary percutaneous intervention: A four-year prospective study

Abstract: Background: Red cell distribution width (RDW) is an indicator of erythrocyte in different size, and its prognostic value has been demonstrated in numerous cardiac (Cardiol J 2016; 23, 3: 281-288)

Cited by 20 publications

References 29 publications

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

Combined value of red blood cell distribution width and global registry of acute coronary events risk score on predicting long-term major adverse cardiac events in STEMI patients undergoing primary PCI

Red blood cell distribution width independently predicts medium-term mortality and major adverse cardiac events after an acute coronary syndrome

Major Adverse Cardiovascular Events: An Inevitable Outcome of ST-elevation myocardial infarction? A Literature Review

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