The impact and effect of liver insufficiency of HCV infection on patients with chronic obstructive pulmonary diseases

El-Habashy, Mahmoud M.; El-Dahdouh, Samy S.; Mohamed, A. M.

doi:10.1016/j.ejcdt.2013.11.003

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…In the current study, patients with HCV had lower FEV 1 values, increased BODE index, and fewer partial pressure of carbon dioxide compared to patients without HCV (8) infection. This report is in concordance with previous findings (17)(18)(19). The BODE index is a prognostic parameter in COPD (21).…”

Section: Discussionsupporting

confidence: 93%

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Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study

Bai

Tian

2021

Jundishapur J Microbiol

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Background: Patients with hepatitis virus C (HCV) infection have declined levels of forced expiratory volume (FEV), which is a prognostic marker for chronic obstructive pulmonary disease (COPD). Objectives: The current study primarily aimed to investigate the incidence of subclinical HCV infection (clinical signs are absent but positive HCV RNA test performed by polymerase chain reaction) in patients with COPD of Zhejiang province, China, and its secondary aim was to investigate the clinical influence of HCV infection on COPD severity by body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) scoring index and pulmonary function tests (PFT). Methods: A total of 252 patients with COPD (confirmed by routine lab tests, BODE index, and PFT) were included in a cross-sectional multicenter study. An anti-HCV antibody test was used to diagnose HCV infection. Hepatitis virus C RNA was tested for patients with a HCV antibody-positive test. Results: Twelve patients had a positive anti-HCV antibody test. Of 12 anti-HCV antibody positive test patients, 10 were positive for the HCV RNA. The prevalence of anti-HCV antibody positivity and HCV RNA positivity was 12/ 252 and 10/ 252, respectively. The partial arterial pressure of oxygen was the same for patients with HCV RNA positive test compared to those with a negative anti-HCV antibody test (59.70 ± 5.50 mmHg vs. 63.84 ± 15.63 mmHg, P = 0.791). Patients with a positive HCV RNA test had a higher partial arterial pressure of carbon dioxide compared to those with a negative anti-HCV antibody test (43.70 ± 1.89 mmHg vs. 49.42 ± 7.33 mmHg, P = 0. 007). BODE index was higher for patients with HCV RNA positive test than those with anti-HCV antibody test negative (6 (3 - 7) vs. 4 (2 - 6), P < 0.0001). Among the variables of BODE index scoring, the values of distance walked in 6 min (P < 0.0001) and % predicted forced expiratory volume in 1 s (P < 0.0001) were fewer for patients with HCV RNA positive test than those with a negative anti-HCV antibody test. Conclusion: This study demonstrated that subclinical HCV infection may be observed in COPD patients.

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Section: Discussionsupporting

confidence: 93%

“…Patients with HCV infection are observed with declined FEV value, which is a prognostic marker for COPD conditions (16). Some studies (17)(18)(19) are available worldwide, but scanty studies are available in the prevalence of HCV with COPD on the Chinese population.…”

Section: Introductionmentioning

confidence: 99%

Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study

Bai

Tian

2021

Jundishapur J Microbiol

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“…The presence of HCV is also associated with worse lung function in another study -FEV 1 67 vs. 55%. 12 Lung function in this study showed correlation with the severity of liver damage according to Child (mean FEV 1 61% in Child A, 51% -Child B, 51% -Child C). However, there is no difference in the degree of obstruction (FEV 1 /FVC) among patients with Child A, B and C, probably due to the decrease in FVC (presence of ascites, which hinders the movement of the diaphragm).…”

Section: Hcv In Copdsupporting

confidence: 50%

Chronic Obstructive Pulmonary Disease and Hepatitis C

Mekov¹,

Petkov²,

Kostadinov³

et al. 2017

Folia Medica

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Chronic obstructive pulmonary disease (COPD) is a preventable, treatable disease with significant extrapulmonary manifestations that could affect negatively its course in some patients. Hepatitis C virus infection (HCV), on the other hand, is associated with a number of extrahepatic manifestations. COPD patients have increased prevalence of HCV and patients with HCV, especially older ones, have increased prevalence and faster progression of COPD. HCV infection exerts long-term effects on lung tissue and is an additional risk factor for the development of COPD. The presence of HCV is associated with an accelerated loss of lung function in COPD patients, especially in current smokers. COPD could represent extrahepatic manifestation associated with HCV infection. The aim of this article was to review the literature on prevalence of HCV in COPD and vice versa, pathogenetic link and the consequences of their mutual existence.

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A high accuracy cantilever array sensor for early liver cancer diagnosis

Wang

Zhu

et al. 2016

Biomed Microdevices

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Early liver cancer diagnosis has clinical significance in treating cancer. Joint detection of multiple biomarkers has been considered as an effective and reliable method for early cancer diagnosis. In this work, a novel biosensor based on microcantilever array was batch-fabricated for multiple liver cancer biomarkers detection with high sensitivity, high accuracy, high throughput, and high specification. A micro-cavity was designed in the free end of the cantilever for local reaction between antibody and antigen, which can dramatically reduce the effect of adsorption-induced stiffness coefficient k variation. Furthermore,the pillar arrays in the micro-cavity were designed for increasing detection upper limit. A linear relationship between the relative frequency shift and the antigen concentration was observed for three liver cancer biomarkers, alpha-fetoprotein (AFP), γ-glutamyltranspeptidase II (GGT-2), and hepatocyte growth factor (HGF). Slight cross-reaction response to different antigens ensures high specificity of the sensor. These features will promote clinical application of the cantilever sensors in early cancer diagnosis.

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The impact and effect of liver insufficiency of HCV infection on patients with chronic obstructive pulmonary diseases

Cited by 4 publications

References 17 publications

Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study

Subclinical Hepatitis C Virus Infection in Patients with Chronic Obstructive Pulmonary Disease: Evidence from a Cross-Sectional Multicenter Observation Study

Chronic Obstructive Pulmonary Disease and Hepatitis C

A high accuracy cantilever array sensor for early liver cancer diagnosis

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