2004
DOI: 10.1016/j.neures.2004.07.005
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The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers

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Cited by 55 publications
(36 citation statements)
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“…By inhibition of the phosphatase calcineurin, dephosphorylation and activation of the transcription factor NF-AT (nuclear factor of activated T cells) is prevented, and synthesis of T cell-activated cytokines such as interleukin-2 is blocked [4,24]. It has been suggested that topical calcineurin inhibitors have a direct effect on heat receptors and the capsaicin receptor TRPV1 [8,9,25]. Activation of TRPV1 leads to neurogenic inflammation, which, in turn, can cause burning pain.…”
Section: Discussionmentioning
confidence: 99%
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“…By inhibition of the phosphatase calcineurin, dephosphorylation and activation of the transcription factor NF-AT (nuclear factor of activated T cells) is prevented, and synthesis of T cell-activated cytokines such as interleukin-2 is blocked [4,24]. It has been suggested that topical calcineurin inhibitors have a direct effect on heat receptors and the capsaicin receptor TRPV1 [8,9,25]. Activation of TRPV1 leads to neurogenic inflammation, which, in turn, can cause burning pain.…”
Section: Discussionmentioning
confidence: 99%
“…chronic irritative hand dermatitis, lichen sclerosus), including PN [6,7]. Pimecrolimus and tacrolimus are assumed to have, like capsaicin, an antipruritic effect by virtue of their influence on sensory cutaneous neurons and the phosphorylation of transient receptor potential subtype vanilloid 1 (TRPV1) receptor [8,9]. Therefore, pimecrolimus can be expected to have high antipruritic efficacy not only in the treatment of atopic dermatitis.…”
Section: Introductionmentioning
confidence: 99%
“…Topical application of tacrolimus causes skin burning and pruritus in some patients. 7) Tacrolimus increases intracellular Ca 2ϩ concentration in small population of capsaicin-sensitive sensory neurons and enhances discharges of heat-sensitive cutaneous C-fibers in vitro, 8) suggesting that tacrolimus acts directly on some capsaicin-sensitive primary afferents. These findings raise the possibility that tacrolimus acts directly on itch-signaling and capsaicin-sensitive primary afferents.…”
Section: Discussionmentioning
confidence: 99%
“…7) Tacrolimus produces the transient increase of discharge in cutaneous C-fibers in the skin-nerve preparation. 8) Tacrolimus also increases intracellular Ca 2ϩ concentration in a small population of sensory neurons in the primary culture and most of tacrolimus-sensitive neurons respond to capsaicin. 8) Capsaicin-sensitive sensory nerves may be involved in signaling of itch as well as pain.…”
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confidence: 99%
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