Pruritus 2009
DOI: 10.1007/978-1-84882-322-8_2
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Neuroreceptors and Neuromediators

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Cited by 4 publications
(3 citation statements)
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“…The binding of capsaicinoids to TRPV1 initially induces pain and burning. If the application of capsaicinoids is continued, defunctionalization of the neurons leads to long‐lasting relief of pain and pruritus …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The binding of capsaicinoids to TRPV1 initially induces pain and burning. If the application of capsaicinoids is continued, defunctionalization of the neurons leads to long‐lasting relief of pain and pruritus …”
Section: Introductionmentioning
confidence: 99%
“…If the application of capsaicinoids is continued, defunctionalization of the neurons leads to longlasting relief of pain and pruritus. [5][6][7][8] Numerable dermal formulations that contain capsaicinoids exist for the treatment of pain. However, there is still no authorized product for the treatment of chronic itch on the market.…”
Section: Introductionmentioning
confidence: 99%
“…Binding of capsaicinoids to TRPV 1 results in release of substance P, calcitonin gene-related peptide and other vasodilatative substances inducing neurogenic inflammation and oedema. If application of capsaicinoids is continued, the persistent influx of cations, mainly calcium, leads to defunctionalisation of neurons resulting in long-lasting relief of pain and pruritus [5,6,7,8]. …”
Section: Introductionmentioning
confidence: 99%