The immunomodulatory activities of licorice polysaccharides (Glycyrrhiza uralensis Fisch.) in CT 26 tumor-bearing mice

Ayeka, Peter Amwoga; Bian, Yuhong; Githaiga, Peter; Zhao, Ying

doi:10.1186/s12906-017-2030-7

Cited by 103 publications

(78 citation statements)

References 55 publications

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“…In a meta-analysis of 8 trials utilizing SHEN QI FU ZHENG Injection (SFI), Xu et al (2017) found that the formula consisting of Codonopsis (dang shen) and Radix astragalus (huang qi) could improve chemotherapy outcomes, and improve immune function, upregulating CD3 + , CD4 + , CD4 + /CD8 + , and NK + cells. They also found that SFI could reduce adverse side effects such as leukocytopenia, thrombocytopenia and gastrointestinal toxicity Chen et al, Chen et al, 2017;Liu et al, 2014;Wang et al, 2017a;Ayeka et al, 2017;Zhang et al, 2018;Zhao et al, 2012;Ma et al, 2014 and Ding et al, Wu et al, 2009;Wang et al, 2018a;Hsieh et al, 2003;Gupta et al, 2004;Yadav and Lee, 2006;Yang et al, 2010;Bo et al, 2017;Willimott et al, 2007;Ma et al, 2008;Chang et al, 2011;Cai et al, (Xu et al, 2017). Though the meta-analysis pointed out the shortcomings of the included trials (the small sample size was 772, and lacked double-blind controls), it did provide encouraging results that warrant larger, better quality clinical trials.…”

Section: Fuzheng Combined With Quxiementioning

confidence: 98%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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Traditional Chinese medicine is an accepted and integral part of clinical cancer management alongside Western medicine in China. However, historically TCM physicians were unaware of the chemical constituents of their formulations, and the specific biological targets in the body. Through HPLC, flow cytometry, and other processes, researchers now have a much clearer picture of how herbal medicine works in conjunction with the immune system in cancer therapy. Among them, the regulation of tumor-related T cells plays the most important role in modulating tumor immunity by traditional Chinese medicine. Encouraging results have been well-documented, including an increase in T cell production along with their associated cytokines, enhanced regulation of Tregs and important T cell ratios, the formation and function of Tregs in tumor microenvironments, and the promotion of the number and function of normal T Cells to reduce conventional cancer therapy side effects. Chinese herbal medicine represents a rich field of research from which to draw further inspiration for future studies. While promising agents have already been identified, the vast majority of Chinese herbal mechanisms remain undiscovered. In this review, we summarize the effects and mechanisms of specific Chinese herbs and herbal decoctions on tumor related T cells.

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Section: Fuzheng Combined With Quxiementioning

confidence: 98%

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Hoffman

et al. 2020

Front. Pharmacol.

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“…LZD is mostly used for the relief of nausea or vomiting, stomachache, diarrhea or watery stools, and rugitus. Modern studies have demonstrated that extracts or compounds from CR [7][8][9] or GRR [10][11][12][13] possess multiple physiological effects, such as anti-inflammation, antioxidation, gastrointestinal function regulation, and immune function regulation. We have shown that AMR stimulated gastrointestinal epithelial repair through polyamine-mediated Ca 2+ and K + signaling pathways [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway

Song

Zeng

Chen

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Administration of nonsteroidal anti-inflammatory drugs (NSAIDs) often causes small intestinal ulcers in patients, but few effective drugs are currently available to manage such serious adverse events of NSAIDs. Li-Zhong decoction (LZD), a well-known traditional Chinese medicine (TCM) formula, is commonly prescribed for treatment of gastrointestinal diseases. The present study aimed to investigate the anti-ulcerogenic activity of LZD on indomethacin- (IND-) induced duodenal ulcer in rats. Mechanistic studies of action of LZD were focused on involvement of TLR-2/MyD88 signaling pathway. Methods. Fifty male Sprague-Dawley (SD) rats were randomly and evenly divided into five groups: normal control, ulcer control (IND, 25 mg/kg), IND + esomeprazole (ESO, 4.17 mg/kg), and IND + low and high doses of LZD (3.75 and 7.50 g/kg). Macroscopic and histopathological examinations were performed for evaluation of ulcer index (UI), curative index (CI), and microscopic score (MS). Levels of duodenal inflammatory biomarkers and cytoprotective mediators including interleukin-4 (IL-4), IL-10, tumor necrosis factor-α (TNF-α), and prostaglandin E2 (PGE2) were measured by ELISA. Expression levels of TLR-2 and MyD88 mRNA were assessed by qRT-PCR. The expression and distribution of TLR-2 and MyD88 proteins were analyzed by western blot and immunohistochemistry, respectively. Results. Gross and microscopic examinations of the IND-treated rats revealed severe duodenal hemorrhagic necrosis, inflammatory infiltration, villus destruction, and crypt abscess, while LZD-treated rats manifested these pathological events to a markedly lesser degree. LZD significantly decreased UI and MS, increased CI, preserved the integrity of the villus and crypt, and normalized the tissue architecture of the duodenum of rats. The elevated TNF-α levels in the IND-treated rats were markedly diminished in the LZD-treated rats, while lower levels of IL-4, IL-10, and PGE2 observed in IND-treated rats were significantly increased in LZD-treated rats. Interestingly, improvement of immune function in duodenal mucosa by reduction of mRNA and protein expression levels of TLR-2 and MyD88 was also observed in rats treated with LZD. Consistently, immunohistochemical analyses revealed a lower co-localization of TLR-2 and MyD88 proteins in the duodenal mucosa of LZD-treated rats as compared to the IND-induced rats. Conclusions. Our data demonstrate that LZD protects the duodenal mucosa from IND-caused lesions, which is at least partially attributable to the interaction of its potential cytoprotective and anti-inflammatory mechanisms together with enhancement of the mucosal immunity through TLR-2/MyD88 signaling pathway.

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“…Immunosuppression could occur when immune cells are reduced and/or affected by inhibitory signals such as immune checkpoints molecules including T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1) [11]. Immunotherapy against cancer has focused on overcoming the immunosuppression of immune cells by improving immunological activity and inhibiting these immune checkpoints [12,13].…”

Section: Introductionmentioning

confidence: 99%

Potential role of immunological factors in early diagnosis of cancer cachexia in C26 tumor-bearing mice

Kim

Kang

et al. 2019

Appl Biol Chem

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Cachexia is a wasting syndrome associated with high mortality in cancer patients through inducing the failure of normal metabolism and reducing the efficacy of cancer treatment. Thus, it is critically important to diagnose cancer cachexia early. To provide background data for the diagnosis of cachexia, cancer cachectic factors were characterized in the present situation, including immunological cachectic changes during cachexia progression in a cancer cachexia mouse model. Major constitution of cachexia progression is known as the stages of pre-cachexia, cachexia, and refractory cachexia. In the pre-cachexia stage, the weights of immune-related organs, including the thymus and spleen were significantly. T cell populations in spleen were markedly reduced and cachectic cytokines consistently increased in a time-dependent manner. Immunosuppression by activation of cytotoxic T-lymphocyte-associated antigen 4 was induced earlier in CD4 + cells versus other T cell populations. Furthermore, monocyte chemoattractant protein 1 and interleukin-6 levels in the cachexia group were significantly increased at 3 days from C26 cell inoculation whereas significant carcass weight loss as a classical diagnostic marker occurred at 9 days from C26 cell inoculation. In conclusion, the initiation of cachectic immunological changes was observed prior to weight loss, during the pre-cachexia stage. Accordingly, these findings reveal that the monitoring of humoral and immunological factors may be more sensitive than weight loss for the initial diagnosis and treatment of cachexia. which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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The immunomodulatory activities of licorice polysaccharides (Glycyrrhiza uralensis Fisch.) in CT 26 tumor-bearing mice

Cited by 103 publications

References 55 publications

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Chinese Herbal Medicine and Its Regulatory Effects on Tumor Related T Cells

Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway

Potential role of immunological factors in early diagnosis of cancer cachexia in C26 tumor-bearing mice

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