The Immunology of Sarcoidosis

Scadding, J. G.; Mitchell, D. N.

doi:10.1007/978-1-4899-2971-6_20

Cited by 7 publications

(5 citation statements)

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“…In 1967, Scadding wrote that, according to general experience, carefully describing the clinical features and pathological data of a disease is fundamental in order to properly identify it and that after a variable observation period, it is possible to formulate the essential facts that characterize it [3]. The aim of this work was precisely to characterize Crohn's disease in our population, primarily on clinical grounds, with a reasonable degree of certainty.…”

Section: Introductionmentioning

confidence: 99%

Clinical Diagnostic Clues in Crohn's Disease: A 41-Year Experience

Quintana

Galleguillos

Benavides

et al. 2012

ISRN Gastroenterology

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Determining the diagnosis of Crohn's disease has been highly difficult mainly during the first years of this study carried out at the Pontificia Universidad Catolica (PUC) Clinical Hospital. For instance, it has been frequently confused with Irritable bowel syndrome and sometimes misdiagnosed as ulcerative colitis, infectious colitis or enterocolitis, intestinal lymphoma, or coeliac disease. Consequently, it seems advisable to characterize what the most relevant clinical features are, in order to establish a clear concept of Crohn's disease. This difficulty may still be a problem at other medical centers in developing countries. Thus, sharing this information may contribute to a better understanding of this disease. Based on the clinical experience gained between 1963 and 2004 and reported herein, the main clinical characteristics of the disease are long-lasting day and night abdominal pain, which becomes more intense after eating and diarrhoea, sometimes associated to a mass in the abdomen, anal lesions, and other additional digestive and nondigestive clinical features. Nevertheless, the main aim of this work has been the following: is it possible to make, in an early stage, the diagnosis of Crohn's disease with a high degree of certainty exclusively with clinical data?

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Section: Introductionmentioning

confidence: 99%

Clinical Diagnostic Clues in Crohn's Disease: A 41-Year Experience

Quintana

Galleguillos

Benavides

et al. 2012

ISRN Gastroenterology

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“…First, sarcoidosis usually presents in young and middle‐aged adults and our patient was relatively old. Second, < 25% of patients present with extrathoracic symptoms while half are asymptomatic on presentation 11 . Third, pleural effusion is very uncommon in sarcoidosis.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses

Chang

Chan²,

Chong³

et al. 2003

Respirology

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Sarcoidosis is rarely reported in Hong Kong. We report cutaneous and pulmonary sarcoidosis in a 54-year-old Chinese woman, who presented with papular lesions over the face and neck. She had silicone breast augmentation surgery 4 years earlier. Skin biopsy revealed granulomatous inflammation and anti-tuberculosis treatment was started empirically but stopped 2 months later owing to a poor response. A right supraclavicular lymph node was aspirated and revealed granulomatous inflammation. The CXR was normal initially but subsequently showed diffuse reticulonodular opacities and a small right-sided pleural effusion. High-resolution CT of the thorax showed mediastinal lymphadenopathy and diffuse perilymphatic nodular opacities consistent with sarcoidosis. Sputum mycobacterial culture was negative. Fibreoptic bronchoscopy showed no endobronchial lesion but the transbronchial biopsy showed granulomatous inflammation with no evidence of infection, malignancy or foreign body. Pulmonary function tests were normal except for impairment of transfer factor. One year later, most of the cutaneous lesions had healed spontaneously. The CXR showed partial improvement of the right pleural opacification but little change in the lung field. The features of sarcoidosis and its association with silicone are reviewed.

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“…patients. 12 This anergy to tuberculoprotein appears to parallel disease activity, being present when disease is active and disappearing months to years after resolution of disease. 13 More important, most patients with active sarcoidosis who become infected with tuberculosis acquire a positive skin test.…”

Section: Cellular Immune Abnormalitiesmentioning

confidence: 99%

Immunology of Sarcoidosis

Daniele¹

1991

Semin Respir Crit Care Med

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The Immunology of Sarcoidosis

Cited by 7 publications

References 0 publications

Clinical Diagnostic Clues in Crohn's Disease: A 41-Year Experience

Clinical Diagnostic Clues in Crohn's Disease: A 41-Year Experience

Cutaneous and pulmonary sarcoidosis in a Hong Kong Chinese woman with silicone breast prostheses

Immunology of Sarcoidosis

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