The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo

Bo, Ruonan; Zheng, Simin; Xing, Jie; Luo, Li; Niu, Yale; Huang, Yee; Liu, Zhenguang; Hu, Yuanliang; Liu, Jiaguo; Wu, Yi; Wang, Deyun

doi:10.1016/j.ijbiomac.2015.12.089

Cited by 67 publications

(33 citation statements)

References 32 publications

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“…27e30 These have been combined with nanoparticles for mucosal vaccination, and this seems to be a growing trend with a variety of plant polysaccharides. 31,32…”

Section: Plant Polysaccharidesmentioning

confidence: 99%

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Woods

Niwasabutra

Acevedo

et al. 2017

Immunopotentiators in Modern Vaccines

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“…27e30 These have been combined with nanoparticles for mucosal vaccination, and this seems to be a growing trend with a variety of plant polysaccharides. 31,32…”

Section: Plant Polysaccharidesmentioning

confidence: 99%

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Woods

Niwasabutra

Acevedo

et al. 2017

Immunopotentiators in Modern Vaccines

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“…Lycium barbarum polysaccharides (LBPs) are important active constituents extracted from the traditional Chinese herb L. barbarum. There are scientific proofs of its pharmacological and biological functions including anti-oxidative properties, 14 immunomodulation, 15 antitumor activity, 16 anti-ageing effect, 17 neuroprotection, 18 hypoglycaemic and hypolipidemic effects 19 and male fertility-facilitating, 20 indicating extensive application prospects on relevant diseases. To the best of our knowledge, there are only a few studies concerning the effect of LBPs on cardiovascular system.…”

mentioning

confidence: 99%

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Zhang

Niu

et al. 2018

J Cellular Molecular Medi

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MicroRNA‐1 (miR‐1) stands out as the most prominent microRNA (miRNA) in regulating cardiac function and has been perceived as a new potential therapeutic target. Lycium barbarum polysaccharides (LBPs) are major active constituents of the traditional Chinese medicine based on L. barbarum. The purpose of this study was to exploit the cardioprotective effect and molecular mechanism of LBPs underlying heart failure. We found that LBPs significantly reduced the expression of myocardial miR‐1. LBPs improved the abnormal ECG and indexes of cardiac functions in P‐V loop detection in transgenic (Tg) mice with miR‐1 overexpression. LBPs recovered morphological changes in sarcomeric assembly, intercalated disc and gap junction. LBPs reversed the reductions of CaM and cMLCK, the proteins targeted by miR‐1. Similar trends were also obtained in their downstream effectors including the phosphorylation of MLC2v and both total level and phosphorylation of CaMKII and cMyBP‐C. Collectively, LBPs restored adverse structural remodelling and improved cardiac contractile dysfunction induced by overexpression of miR‐1. One of the plausible mechanisms was that LBPs down‐regulated miR‐1 expression and consequently reversed miR‐1‐induced repression of target proteins relevant to myocardial contractibility. LBPs could serve as a new, at least a very useful adjunctive, candidate for prevention and therapy of heart failure.

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“…It has been shown that LBP can act as an adjuvant for the generation of Tfh cells to enhance T celldependent antibody responses [15]. It has also been demonstrated that LBP can promote cytokine secretion in macrophages, Th1, and Th2 [16]. Researchers have consistently shown that LBP significantly induces proliferation of T lymphocytes [4,17].…”

Section: Discussionmentioning

confidence: 99%

Impact of <i>Lycium barbarum</i> polysaccharide on apoptosis in <i>Mycoplasma</i>-infected splenic lymphocytes

Huang¹,

Zheng²,

Xu³

2017

Trop. J. Pharm Res

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The immunological activity of Lycium barbarum polysaccharides liposome in vitro and adjuvanticity against PCV2 in vivo

Cited by 67 publications

References 32 publications

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Natural Vaccine Adjuvants and Immunopotentiators Derived From Plants, Fungi, Marine Organisms, and Insects

Lycium barbarum polysaccharides restore adverse structural remodelling and cardiac contractile dysfunction induced by overexpression of microRNA‐1

Impact of <i>Lycium barbarum</i> polysaccharide on apoptosis in <i>Mycoplasma</i>-infected splenic lymphocytes

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