Impact of &lt;i&gt;Lycium barbarum&lt;/i&gt; polysaccharide on apoptosis in &lt;i&gt;Mycoplasma&lt;/i&gt;-infected splenic lymphocytes

Huang, Bo; Zheng, Weikun; Xu, Zhi-wei

doi:10.4314/tjpr.v16i9.12

Cited by 4 publications

(7 citation statements)

References 20 publications

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“…LBP has demonstrated antioxidizing and anti-apoptotic effects in vitro [ 28 , 38 , 39 , 125 ]. By reducing oxidative stress and other harmful factors related to ageing, LBP can reduce DNA fracture damage, strengthen cell activity, and achieve anti-ageing effects on cells.…”

Section: Resultsmentioning

confidence: 99%

“…By reducing oxidative stress and other harmful factors related to ageing, LBP can reduce DNA fracture damage, strengthen cell activity, and achieve anti-ageing effects on cells. LBP was able to upregulate the nuclear factor E2-related factor 2 (Nrf2) [ 38 , 39 , 125 ] and induce translocation of cytoplasmic Nrf2 to the nucleus to bind to the antioxidant response element (ARE) [ 38 ]. Moreover, LBP could down-regulate the expression of the transcription inhibitor Bach1, reducing the competition with Nrf2 for binding to ARE.…”

Section: Resultsmentioning

confidence: 99%

“…an upregulation of the SOD and CAT levels [29]. Moreover, LBP has been studied in the reproductive system [30][31][32][33][34][35][36][37] as well as in the cells and tissues derived from different germ layers [38][39][40][41][42][43][44][45][46][47][48] to evaluate its protective value. Again, LBP performed excellently in scavenging free radicals, maintaining mitochondrial function and showed exquisite antioxidant effects.…”

Section: Introductionmentioning

confidence: 99%

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Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Kong

et al. 2021

BMC Complement Med Ther

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Background Lycium barbarum polysaccharide (LBP), the most abundant functional component of wolfberry, is considered a potent antioxidant and an anti-ageing substance. This review aims to outline the hallmarks of ageing in the pathogenesis of osteoarthritis (OA), followed by the current understanding of the senolytic effect of LBP and its potential use in the prevention and treatment of OA. This will be discussed through the lens of molecular biology and herbal medicine. Methods A literature search was performed from inception to March 2020 using following keywords: “Lycium barbarum polysaccharide”, “DNA damage”, antioxidant, anti-apoptosis, anti-inflammation, anti-ageing, osteoarthritis, chondrocytes, fibroblasts, osteoblasts, osteoclasts, and “bone mesenchymal stem cell”. The initial search yielded 2287 papers, from which 35 studies were selected for final analysis after screening for topic relevancy by the authors. Results In literature different in vitro and in vivo ageing models are used to demonstrate LBP’s ability to reduce oxidative stress, restore mitochondrial function, mitigate DNA damage, and prevent cellular senescence. All the evidence hints that LBP theoretically attenuates senescent cell accumulation and suppresses the senescence-associated secretory phenotype as observed by the reduction in pro-inflammatory cytokines, like interleukin-1beta, and matrix-degrading enzymes, such as MMP-1 and MMP-13. However, there remains a lack of evidence on the disease-modifying effect of LBP in OA, although its chondroprotective, osteoprotective and anti-inflammatory effects were reported. Conclusion Our findings strongly support further investigations into the senolytic effect of LBP in the context of age-related OA.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Kong

et al. 2021

BMC Complement Med Ther

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“…Polysaccharides from fungus, algae, and other plants are reported to have strong pharmacological activities through modulating immune balance and may treat cancers via immunotherapy [ 11 , 12 , 13 , 14 , 15 ]. To investigate pharmacological effects of guava seed polysaccharides and achieve optimal concentrations for bioassays, GSPS, GSF1, GSF2, and GSF3 at 0, 1.6, 8, 40, 200, and 500 μg/mL were respectively administered to primary splenocytes for 72 hrs.…”

Section: Discussionmentioning

confidence: 99%

“…As potent BRMs, polysaccharides that enhance immunity, but have a low cytotoxicity to host cells, attract much attention for their important role in cancer immunotherapy [ 3 , 6 , 7 , 8 , 9 , 10 ]. Besides, polysaccharides isolated from fungus, algae, and seeds have been found to have strong pharmacological activities for cancer immunotherapy [ 11 , 12 , 13 , 14 , 15 ]. Most recently, polysulfated polysaccharides heparin like compounds, glycosaminoglycans, in combination with vitamin B17 have been suggested as a possible treatment for prostate cancer [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro

Lin

2021

IJMS

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The inhibitory effects of purified fractions isolated from guava seed polysaccharides (GSPS) including guava seed polysaccharide fraction 1 (GSF1), GSF2, and GSF3 on prostate cancer cells remain unclear. To clarify the anti-prostate cancer potential, GSPS, GSF1, GSF2, and GSF3 were isolated using Sepharose 6B gel filtration chromatography to assay their inhibitory effects on prostate PC-3 cell growth with direct action or indirect immunotherapy using either splenocyte conditioned media (SCM) or macrophage conditioned media (MCM). Correlations between cytokine profiles in the conditioned media and pro-apoptotic gene expression levels in the corresponding treated PC-3 cells were analyzed. Results showed that GSPS, GSF1, GSF2, and GSF3, particularly GSF3, through either direct action or indirect treatments using SCM or MCM, significantly (p < 0.05) inhibited PC-3 cell growth. GSF3 direct treatments increased pro-apoptotic Bax/anti-apoptotic Bcl-2 mRNA expression ratios in corresponding treated PC-3 cells. Either SCM or MCM cultured with GSF3 increased Fas mRNA expression levels in corresponding treated PC-3 cells. Both Th2-polarized and anti-inflammatory cytokine IL-10 either secreted in SCM or MCM were positively correlated with Fas mRNA expression levels in corresponding treated PC-3 cells. Our results suggest that GSF3 is a potent biological response modifier to decrease PC-3 cell growth through inducing apoptosis.

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Recent progress of Lycium barbarum polysaccharides on intestinal microbiota, microbial metabolites and health: a review

Feng

Song

Zhou

et al. 2022

Critical Reviews in Food Science and Nutrition

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Impact of <i>Lycium barbarum</i> polysaccharide on apoptosis in <i>Mycoplasma</i>-infected splenic lymphocytes

Cited by 4 publications

References 20 publications

Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Lycium barbarum polysaccharides in ageing and its potential use for prevention and treatment of osteoarthritis: a systematic review

Pharmacological Effects of Guava (Psidium guajava L.) Seed Polysaccharides: GSF3 Inhibits PC-3 Prostate Cancer Cell Growth through Immunotherapy In Vitro

Recent progress of Lycium barbarum polysaccharides on intestinal microbiota, microbial metabolites and health: a review

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