The immunogenetics of resistance toTrichostrongylus colubriformis and Haemonchus contortus parasites in sheep

Hohenhaus, M. A.; Outteridge, P.M.

doi:10.1016/s0007-1935(95)80004-2

Cited by 28 publications

(12 citation statements)

References 48 publications

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“…However, temporal homogeneity does not necessarily preclude the occurrence of pathogen mediated selection in this population for DQA (see also Hohenhaus and Outteridge, 1995;Deter et al, 2008). Possibly, the intensity of selection was similar across cohorts as this population has not suffered from a significant disease outbreak during the period under study.…”

Section: Tablementioning

confidence: 88%

MHC class II DQA gene variation across cohorts of brown hares (Lepus europaeus) from eastern Austria: Testing for different selection hypotheses

Campos¹,

Bellocq²,

Schaschl³

et al. 2011

Mammalian Biology

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a b s t r a c tWe have studied the temporal variation (1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007) in the MHC class II DQA gene and 8 microsatellites across 8 cohorts in a population of brown hare (Lepus europaeus) from eastern Austria. Our results show no significant temporal changes in allele frequencies both in microsatellites and the DQA gene. Although positive selection on a larger evolutionary time scale has occurred in DQA, we have not observed evidence of contemporary balancing selection in this gene. Our results are not compatible with the negative frequency-dependent selection or the variable selection in time hypotheses within a timeframe of 8 consecutive generations. However, selection heterogeneity in space occurs. The studied cohorts have probably not been exposed to strong effects of parasites and pathogens during the period of this study, as indicated by our endoparasite counts and infection data. Furthermore, the most common DQA allele (Leeu-DQA*06) was found to be in a stable frequency equilibrium which is consistent with the occurrence of stabilizing selection. This could indicate that major selective agents have been rather constant in their frequency across our temporal samples.

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Section: Tablementioning

confidence: 88%

MHC class II DQA gene variation across cohorts of brown hares (Lepus europaeus) from eastern Austria: Testing for different selection hypotheses

Campos¹,

Bellocq²,

Schaschl³

et al. 2011

Mammalian Biology

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show abstract

“…The expression of MHC products on cell membranes is necessary for antigen presentation to T lymphocytes by macrophages or dendritic cells (Hohenhaus and Outteridge, 1995). Some of the most commonly used genetic markers in association studies are the short tandem repeat DNA sequences, also known as microsatellites.…”

Section: Introductionmentioning

confidence: 99%

Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus

Figueroa-Castillo

Medina

Villalobos

et al. 2011

Veterinary Parasitology

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“…A eosinofilia é citada em diversos artigos como, junto com a mastocitose tecidual, uma resposta comum a diversos parasitos e em diversos hospedeiros (MACKENZIE & SPRY, 1983;CHEEMA & SCOFIELD, 1985, ROTHWEEL, 1989SMITH & BRYANT, 1989;HOHENHAUS & OUTTERIDGE, 1995;STEAR et al, 1995;PATTERSON et al, 1996;WINTER et al, 1997;SUAREZ et al, 1999).…”

Section: Eritrogramaunclassified

“…No entanto, HERNDON et al (1992), trabalhando com infecções por Trichinella spiralis onde a ativação de eosinófilos foi suprimida pelo tratamento dos animais experimentais com anticorpos monoclonais contra o fator de ativação interleucina IL-5, postula que estas células não são essenciais para a expulsão destes parasitas. Por outro lado, parece bem estabelecido que a eosinofilia tem alta correlação com o número de mastócitos e leucócitos globulares na mucosa, e com a presença de plasmócitos produtores de IgA , tendo sido usada inclusive como critério para a seleção de animais resistentes ao parasitismo (WINDON et al, 1980;WINDON & DINEEN, 1981;HOHENHAUS & OUTTERIDGE, 1995;PATTERSON et al, 1996;WOOLASTON et al, 1996).…”

Section: Eritrogramaunclassified

Estudo da inter-relação parasito hospedeiro em bovinos infectados com Cooperia punctata. Efeito da suplementação protéica sobre as alterações fisiopatológicas em bezerros com infecção única.

Oliveira¹

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The immunogenetics of resistance toTrichostrongylus colubriformis and Haemonchus contortus parasites in sheep

Cited by 28 publications

References 48 publications

MHC class II DQA gene variation across cohorts of brown hares (Lepus europaeus) from eastern Austria: Testing for different selection hypotheses

MHC class II DQA gene variation across cohorts of brown hares (Lepus europaeus) from eastern Austria: Testing for different selection hypotheses

Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus

Estudo da inter-relação parasito hospedeiro em bovinos infectados com Cooperia punctata. Efeito da suplementação protéica sobre as alterações fisiopatológicas em bezerros com infecção única.

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