Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus

Figueroa-Castillo, Juan Antonio; Medina, Rubén Danilo Méndez; Villalobos, José Manuel Berruecos; Gayosso-Vázquez, Amanda; Ullóa-Arvízu, Raúl; Rodríguez, Rebeca Acosta; Ramírez, Hugo; Morales, Rogelio Alejandro Alonso

doi:10.1016/j.vetpar.2010.11.056

Cited by 25 publications

(11 citation statements)

References 38 publications

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“…Based on this evidence, it seems that the variability observed in GNI between these two species depends on internal (genetic component) or external factors (feeding behaviour, nutrition and physiological status). Similar studies in hair sheep have reported negative moderate correlations between these two parameters, suggesting that animals with low FEC present high PCV …”

Section: Discussionsupporting

confidence: 74%

“…Similar investigations performed in Merino and Polish sheep have described an association between exon 2 and FEC . Studies performed with Suffolk, Romanov, Scottish Blackface, Ghezel and Pelibuey sheep have identified possible alleles within the Ovar‐DRB1 associated with low FEC during GNI. Thus, it is possible that potential genetic markers for resistance to GNI are located in the Ovar‐DRB1 locus of sheep.…”

Section: Discussionsupporting

confidence: 58%

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Effect of Ovar‐DRA and Ovar‐DRB1 genotype in small ruminants with haemonchosis

Estrada-Reyes

Tsukahara

Goetsch

et al. 2018

Parasite Immunology

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The effect of Ovar-DRA and Ovar-DRB1 genotypes on faecal egg count (FEC) was determined in sheep and goats infected with Haemonchus contortus. One hundred and forty-three sheep from 3 different breeds (St. Croix, Katahdin and Dorper) and 150 goats from three different breeds (Spanish, Boer and Kiko) were used. Parasitological (FEC), haematological (packed cell volume) and immunological (IgA, IgG and IgM) parameters were measured. Sheep populations showed a higher FEC and humoural response than goat breeds. Genotypes were determined by high-resolution melting assays and by conventional PCR. For Ovar-DRA, sheep and goats carrying the AA genotype showed significant lower FEC than AG and GG genotypes. The additive effect was found to be 115.35 less eggs per gram of faeces for the A allele for goats. For Ovar-DRB1, only in sheep, the GC genotype was associated with low FEC. The additive effect was 316.48 less eggs per gram of faeces for the G allele, and the dominance effect was 538.70 less eggs per gram of faeces. The results indicate that single nucleotide polymorphisms within Ovar-DRA and Ovar-DRB1 could be potential markers to be used in selection programmes for improving resistance to Haemonchus contortus infection.

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Section: Discussionsupporting

confidence: 74%

Section: Discussionsupporting

confidence: 58%

Effect of Ovar‐DRA and Ovar‐DRB1 genotype in small ruminants with haemonchosis

Estrada-Reyes

Tsukahara

Goetsch

et al. 2018

Parasite Immunology

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“…Most attention has been focused on finding associations between HLA-DR isoforms and resistance as it is more polymorphic than HLA-DQ and is highly expressed on antigen-presenting cells [87]. The translation from rodent models to sheep produced inconsistent results with some researchers finding significant associations between gene variants of MHC and parasite resistance [89–93], whereas other researchers did not [87, 94]. …”

Section: Ideal Characteristics Of Diagnostic Markers For Gin Parasmentioning

confidence: 99%

Current Status for Gastrointestinal Nematode Diagnosis in Small Ruminants: Where Are We and Where Are We Going?

Preston

Sandeman

González

et al. 2014

Journal of Immunology Research

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Gastrointestinal nematode (GIN) parasites pose a significant economic burden particularly in small ruminant production systems. Anthelmintic resistance is a serious concern to the effective control of GIN parasites and has fuelled the focus to design and promote sustainable control of practices of parasite control. Many facets of sustainable GIN parasite control programs rely on the ability to diagnose infection both qualitatively and quantitatively. Diagnostics are required to determine anthelmintic efficacies, for targeted treatment programs and selection of animals for parasite resistant breeding. This review describes much of the research investigated to date to improve the current diagnostic for the above practices which is based on counting the number of parasite eggs in faeces.

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“…There are many ongoing studies of resistance-associated genetic markers and some preliminary results. Alleles OMHC1-188 and OLADRB2-282 of the major histocompatibility complex (MHC) [25] and several quantitative trait loci (QTL) that contain diverse significant loci, such as the IFN γ locus in chromosome 3 [26, 27], have been associated with FEC reduction. Furthermore, some genes associated with the early inflammatory response including those encoding toll-like receptors (TLR2, 4 and 9) or involved with free radical production (DUOX1 and NOS2 A) are more abundantly expressed in lambs that are resistant to H. contortus and Trichostrongylus colubriformis infections [28].…”

Section: Breeds Susceptible and Resistant To Haemonchosismentioning

confidence: 99%

“…Haemonchosis resistance has been associated with alleles of the ovine MHC (OMHC1-188) and with certain surface molecules of ovine leukocytes (OLADRB2-282), suggesting that the mechanisms of antigen presentation differ between breeds [25, 82]. Some dendritic cells can internalize antigens homologous to those of H. contortus [83], so the specific response to H. contortus may be induced by the dendritic cell-mediated presentation of parasite antigens to helper T lymphocytes.…”

Section: Immune Response In Ovine Haemonchosismentioning

confidence: 99%

Immune Responses Associated with Resistance to Haemonchosis in Sheep

Arenzana-Seisdedos

Muñoz-Guzmán

2013

BioMed Research International

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This paper examines the known immunological and genetic factors associated with sheep resistance to infection by Haemonchus contortus. Such resistance is an inheritable genetic trait (h 2, 0.22–0.63) associated with certain sheep breeds. Resistant sheep do not completely reject the disease; they only harbor fewer parasites than susceptible sheep and therefore have a lower fecal egg count. Protective immune response to haemonchosis is an expression of genetic resistance. Genes associated with resistance and susceptibility are described. Genetically resistant sheep have nonspecific mechanisms that block the initial colonization by Haemonchus contortus larvae. These sheep also have an efficacious Th2 type response (e.g., increases in blood and tissue eosinophils, specific IgE class antibodies, mast cells, IL-5, IL-13, and TNFα) that protects them against the infection; in contrast, susceptible sheep do not efficiently establish this type of immune response. Finally, the main reported antigens of H. contortus were reviewed.

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Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus

Cited by 25 publications

References 38 publications

Effect of Ovar‐DRA and Ovar‐DRB1 genotype in small ruminants with haemonchosis

Effect of Ovar‐DRA and Ovar‐DRB1 genotype in small ruminants with haemonchosis

Current Status for Gastrointestinal Nematode Diagnosis in Small Ruminants: Where Are We and Where Are We Going?

Immune Responses Associated with Resistance to Haemonchosis in Sheep

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