The Immunogenetics of Autoimmune Blistering Diseases

Kneiber, Diana; Kowalski, Eric H.; Amber, Kyle T.

doi:10.1007/978-3-030-92616-8_8

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2024

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Cited by 2 publications

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“…Embora a etiopatogenia ainda não esteja definida (LA SERRA et al, 2019;MACHADO et al, 2017;MIGUEL et al, 2022;VERNAL, DE PAULA et al, 2020), a associação dos alelos HLA com a suscetibilidade ou proteção aos pênfigos permite a diferenciação do PV e PF em termos genéticos (BROCHADO, NASCIMENTO, CAMPOS et al, 2016;KNEIBER et al, 2022;PETZL-ERLER, 2020).…”

Section: Lista De Figurasunclassified

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Oliveira¹

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Section: Lista De Figurasunclassified

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Oliveira¹

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Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment

Strandmoe,

Bremer,

Diercks

et al. 2024

British Journal of Dermatology

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Pemphigus vulgaris is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmoglein 1. Fundamental research into the pathogenesis of PV has revolutionized its treatment and outcome with rituximab, a B-cell-depleting therapy. The critical contribution of B cells to the pathogenesis of pemphigus is well accepted. However, the exact pathomechanism, mechanisms of onset, disease course, and relapse remain unclear. In this narrative review, we provide an overview of the fundamental research progress that has unfolded over the past centuries to give rise to current and emerging therapies. Furthermore, we summarized the multifaceted roles of B cells in pemphigus vulgaris, including their development, maturation, and antibody activity. Finally, we explored how these various aspects of B-cell function contribute to disease pathogenesis and pave the way for innovative therapeutic interventions.

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The Immunogenetics of Autoimmune Blistering Diseases

Cited by 2 publications

References 281 publications

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment

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The Immunogenetics of Autoimmune Blistering Diseases

Cited by 2 publications

References 281 publications

Polimorfismos genéticos dos receptores da Fc&gamma; IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Polimorfismos genéticos dos receptores da Fc&gamma; IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment

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Product

Resources

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Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe

Polimorfismos genéticos dos receptores da Fcγ IgG nos pênfigos e no desfecho da resposta terapêutica ao Rituximabe