Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatment
Anne-Lise Strandmoe,
Jeroen Bremer,
Gilles F H Diercks
et al.
Abstract:Pemphigus vulgaris is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmoglein 1. Fundamental research into the pathogenesis of PV has revolutionized its treatment and outcome with rituximab, a B-cell-depleting therapy. The critical contribution of B cells to the pathogenesis of pemphigus is well accepted. However, the exact pathomechanism, mechanisms o… Show more
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